Results 21 to 30 of about 5,590 (241)
Teratogens: a public health issue – a Brazilian overview
Genetics and Molecular Biology, 2017 Congenital anomalies are already the second cause of infant mortality in Brazil, as in many other middle-income countries in Latin America. Birth defects are a result of both genetic and environmental factors, but a multifactorial etiology has been more ...
Thiago Mazzu-Nascimento +6 more
doaj +1 more source
Risk factors of congenital heart diseases: A hospital-based case-control study in Isfahan, Iran [PDF]
ARYA Atherosclerosis, 2020 BACKGROUND: Improving knowledge towards risk factors for congenital heart disease (CHD) is important because of its high mortality and morbidity and trying for prevention of occurrence of CHD.METHODS: This case-control study was conducted on a total of ...
Alireza Ahmadi +3 more
doaj +1 more source
Embryonic stem cells: An alternative approach to developmental toxicity testing
Journal of Pharmacy and Bioallied Sciences, 2012 Stem cells in the body have a unique ability to renew themselves and give rise to more specialized cell types having functional commitments. Under specified growth conditions, these cell types remain unspecialized but can be triggered to become specific ...
S Tandon, S Jyoti
doaj +1 more source
Cells, 2022 Human-relevant tests to predict developmental toxicity are urgently needed. A currently intensively studied approach makes use of differentiating human stem cells to measure chemically-induced deviations of the normal developmental program, as in a ...
Florian Seidel +18 more
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DNA Modifications: Function and Applications in Normal and Disease States
Biology, 2014 Epigenetics refers to a variety of processes that have heritable effects on gene expression programs without changes in DNA sequence. Key players in epigenetic control are chemical modifications to DNA, histone, and non-histone chromosomal proteins ...
Vichithra R. B. Liyanage +5 more
doaj +1 more source
Teratogenicity and Teratogenic Factors
MOJ Anatomy & Physiology, 2017 Teratology is the science that investigates the congenital malformations and their causes Intrauterine exposure to a toxicant particularly in early pregnancy induces embryonic and fetal changes ranging from none up to malformations and stillbirths The teratogenic agents include some viral spirochetal and protozoal infections physical agents as ionizing
openaire +1 more source
Journal of Family Medicine and Primary Care, 2020 Aim: To investigate the knowledge of Saudi women regarding the teratogenic effects of environmental agents such as fever, some chronic conditions and medications and its association with certain socio-demographic factors.
Wejdan Alhamdan +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
Arthritis Care &Research, EarlyView.People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective This study aimed to describe real‐world trends in preconception and prenatal use of antirheumatic drugs among pregnant individuals with rheumatic diseases in Ontario, Canada. Methods We conducted a time‐series analysis using repeated cross‐sectional data to examine annual patterns of disease‐modifying antirheumatic drug (DMARD) use among ...
Shenthuraan Tharmarajah +6 more
wiley +1 more source