Results 41 to 50 of about 5,590 (241)

A Review of the Teratogenic Factors Effect on Embryo

Journal of Fasa University of Medical Sciences, 2017
Background & Objectives: Teratology is a branch of embryology science that studies causes, mechanisms and abnormal pattern development. Embryo growth traumatic factors during pregnancy are called teratogens that some teratogens pass the placental barrier
Manzarbanoo Shojaei fard, Samira Malekzadeh, Mehrdad Shariati   +2 more
doaj  

Identification of major congenital malformations based on healthcare databases in France: A proof‐of‐concept study using the epi‐meres nationwide mother–child register

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Besides registries, healthcare databases can provide useful information for assessing the frequency of major congenital malformations (MCMs) and investigating their risk factors, particularly medication exposures. This study aimed to assess the validity of MCMs identification based on French national, comprehensive healthcare databases ...
Tom Duchemin, Lise Marty, Jérôme Drouin, Sara Miranda, Jérémie Botton, Valérie Olié, Alain Weill, Rosemary Dray‐Spira   +7 more
wiley   +1 more source

Characteristics and temporal trends of EU teratological safety signals and information dissemination to healthcare professionals in the Netherlands—A contribution of the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Although regulatory responses to safety signals have been studied, pregnancy‐specific data and their dissemination to medical professionals remain unclear. This study examined the characteristics and temporal trends of teratological safety signals prompting the European Medicines Agency to implement risk minimization measures.
Yrea R. J. van Rijt‐Weetink, Rosanne E. Huisman, Jan‐Peter van Wieringen, H. J. M. J. (Ineke) Crijns, Florence P. A. M. van Hunsel, Anneke L. M. Passier, Sander Borgsteede, A. C. G. (Toine) Egberts, Laura M. Yates, Eugène P. van Puijenbroek   +9 more
wiley   +1 more source

Case‐malformed signal detection and prioritisation using EUROmediCAT data for pharmacovigilance in pregnancy

British Journal of Clinical Pharmacology, EarlyView.
Aim Many women take medications during pregnancy. However, the risk to the fetus from most medications is uncertain. Congenital anomalies are one of the leading causes of infant death and contribute to long‐term disability. Signal detection methods can be used to systematically identify possible medication–anomaly associations that require further ...
Hannah Johnson, Helen Dolk, Maria Loane, Christine Damase‐Michel, Joanne Given, Hedvig Nordeng, Jorieke E. H. Bergman, Iain Carey, Elly Den Hond, Ester Garne, Florence Rouget, Lea Bruneau, Isabelle Monier, Anke Rissmann, Mary O'Mahony, Miriam Gatt, Renée Lutke, Joanna Sichitiu, Elisa Ballardini, Alessio Coi, Clara Cavero Carbonell, David Tucker, Joan Morris   +22 more
wiley   +1 more source

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Sherbet Samuels, Rebecca Racz, Mohamed A. Mohamoud, Nicholas P. Tatonetti   +6 more
wiley   +1 more source

SARS-CoV-2 pseudoparticles preferentially infect ectoderm in human embryonic tissues

Frontiers in Cell and Developmental Biology
IntroductionThe early stages of human embryonic development are challenging to study in pregnant women.MethodsA “disease-in-a-dish” model was utilized to investigate SARS-CoV-2 infection of human embryonic stem cells and the three germ layers (ectoderm ...
Ann Song, Ann Song, Prue Talbot
doaj   +1 more source

Testicular Histological Changes and Ki-67 Expression in Lead (II) Oxide Toxicity among Neonatal Wistar Rats and Modulatory Role of Retinol [PDF]

Archives of Razi Institute
Lead toxicity has been recognized in soft tissues, whereas retinoid facilitates embryonic development during the intrauterine phase and support tissue regeneration.
Babatunde Dare, Kolawole Blessing, Peter Peter, Ebele Cinderela, Obembe, Olawale, Adeleke Samson   +5 more
doaj   +1 more source

Maternal and Neonatal Complications Associated with Breast Cancer Systemic Treatments—A VigiBase Disproportionality Analysis Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnancy‐associated breast cancer (PrBC) presents therapeutic challenges. Understanding maternal–fetal safety of systemic anticancer therapies is critical. We performed a case/non‐case disproportionality analysis using the WHO global pharmacovigilance database up to January 2024, to evaluate maternal–fetal outcomes associated with breast cancer (BC ...
Rayan Kabirian, Floriane Jochum, Elise Dumas, Florence Coussy, Kevin Bihan, Bénédicte Lebrun‐Vignes, Barbara Pistilli, Marc‐Antoine Benderra, Lise Selleret, Laurent Chouchana, Fabien Reyal, Anne‐Sophie Hamy, Paul Gougis   +12 more
wiley   +1 more source

Termination of Pregnancy Following Periconception Isotretinoin Exposure in South Korea

Clinical and Experimental Obstetrics & Gynecology
Background: Despite South Korea’s Ministry of Food and Drug Safety (MFDS) risk management program (RMP) since June 2019, isotretinoin prescriptions have surged 2.5 times from 0.39 million in 2017 to 0.97 million in 2021.
Young-Rae Lee, Dong-Won Hwang, Kyoung-Chul Chun, Young-Ah Kim, Jae-Whoan Koh, Jung-Yeol Han, June-Seek Choi, Hye-Young Kwon   +7 more
doaj   +1 more source

Drug use during pregnancy

Horizonte Médico, 2018
Due to ethical reasons, very scarce clinical assays have been conducted and published. This situation has resulted in the exaggeration of drug risk during pregnancy, thus limiting its reasonable use for chronic diseases in pregnant women.
José Sandoval Paredes, Cindy Sandoval Paz   +1 more
doaj   +1 more source