Results 31 to 40 of about 6,483 (296)
Transcriptomics-based identification of teratogens in differentiating hiPSCs: A novel in vitro test system [PDF]
, 2021 The knowledge about the developmental toxicity potential of substances is a matter of high concern in toxicology and medicine, especially if pregnant women need to take potentially teratogenic drugs to treat severe infections or diseases.
Seidel, Florian
core +1 more source
The effects of teratogens on prenatal human development
, 2021 Teratologija je znanost koja se bavi uzrocima, razvojem, opisivanjem i klasifikacijom urođenih malformacija. Nakon talidomidske katastrofe 60-ih godina 20. stoljeća došlo je do naglog porasta u zanimanju za ovo područje.
Žulj, Iva
core
Journal of Family Medicine and Primary Care, 2020 Aim: To investigate the knowledge of Saudi women regarding the teratogenic effects of environmental agents such as fever, some chronic conditions and medications and its association with certain socio-demographic factors.
Wejdan Alhamdan +7 more
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective This study aimed to describe real‐world trends in preconception and prenatal use of antirheumatic drugs among pregnant individuals with rheumatic diseases in Ontario, Canada. Methods We conducted a time‐series analysis using repeated cross‐sectional data to examine annual patterns of disease‐modifying antirheumatic drug (DMARD) use among ...
Shenthuraan Tharmarajah +6 more
wiley +1 more source
MHC-associated immunopotentiation affects the embryo response to teratogens
, 1994 SUMMARY The present study was performed to evaluate whether the effect of environmental teratogens can be modified by maternal immunostimulation.
HJA Carp, A Torchinsky, V Toder, A Fein
core +1 more source
Advanced Intelligent Discovery, EarlyView.This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng +4 more
wiley +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT The transformation/transcription domain‐associated protein (TRRAP) gene encodes a large multidomain protein, a member of the phosphatidylinositol 3‐kinase‐related kinase (PIKK) family. TRRAP is a component of the histone acetyltransferase (HAT) complex, and it plays an important role in gene transcription, DNA repair, and cell‐cycle regulation.
Roseli Maria Zechi‐Ceide +10 more
wiley +1 more source
Questioning the role of Darwinian medicine [PDF]
, 2001 Darwinian medicine as a distinct scientific discipline can be traced to George Williams' and Randolph Nesse's paper 'The Dawn of Darwinian Medicine' (Q Rev. Biol. 66: 1-22, 1991).
Lewis, Stephen J.
core
Co‐Occurring Non‐Cardiac Congenital Anomalies Among Cases With Congenital Heart Defects
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Cases with congenital heart defects (CHD) often have other associated anomalies. The aim of this investigation was to assess the prevalence and the types of co‐occurring anomalies in CHD in a well‐defined population. The anomalies co‐occurring with CHD were ascertained in all live births, stillbirths and terminations of pregnancy for fetal ...
Claude Stoll +2 more
wiley +1 more source
Discriminative power of an assay for automated in vitro screening of teratogens
, 2004 Udgivelsesdato: 2004-AugScreening for potential teratogenicity of 20 test compounds was performed using a computerised microscope workstation for determination of cytotoxicity, proliferation and morphology of fibroblastoid murine L929-cells.
Nau, Heinz +4 more
core +1 more source