Results 11 to 20 of about 6,483 (296)

Exposure to potentially teratogenic medications before and during the first trimester of pregnancy compared to women of childbearing age: A retrospective analysis of Swiss claims data (2015–2021) [PDF]

Acta Obstetricia et Gynecologica Scandinavica
Introduction Exposure to potentially teratogenic medications during pregnancy is underinvestigated in Switzerland. We aimed to assess exposure to potential teratogens preconceptionally, during the first trimester, and in women of childbearing age, and ...
Carole A. Marxer, Sereina M. Graber, Daniel Surbek, Alice Panchaud, Christoph R. Meier, Julia Spoendlin   +5 more
doaj   +3 more sources

A Scoping Review of Human Teratogens and Their Impact on the Developing Brain: A Contribution From the ConcePTION Project. [PDF]

Birth Defects Res
Certain medications, when used during pregnancy, are known to impact human prenatal development. Historically, little attention has been given to the impact of in utero exposure on the developing brain, despite the significance of known teratogen-induced
Bluett-Duncan M, Adams J, Berkovitch M, Berlin M, Cahoon A, Clayton-Smith J, Jackson C, Khanom S, Mølgaard-Nielsen D, Richardson JL, Simms V, Stellfeld M, Winterfeld U, Yates LM, Bromley RL.   +14 more
europepmc   +4 more sources

Implementing a trilineage differentiation in the ReproTracker assay for improved teratogenicity assessment [PDF]

Frontiers in Toxicology
IntroductionExposure to teratogenic compounds during pregnancy can lead to significant birth defects. Given the considerable variation in drug responses across species, along with the financial and ethical challenges associated with animal testing, the ...
José M. Horcas-Nieto, Sabine Hartvelt, Luke Flatt, Jing Fang, Esther Lam, Gaonan Zhang, Romy Van Vliet, Marleen Feliksik, Tom Zwetsloot, Connor Philippo, Giel Hendriks, Amer Jamalpoor   +11 more
doaj   +2 more sources

Teratogens: a public health issue – a Brazilian overview [PDF]

Genetics and Molecular Biology, 2017
Congenital anomalies are already the second cause of infant mortality in Brazil, as in many other middle-income countries in Latin America. Birth defects are a result of both genetic and environmental factors, but a multifactorial etiology has been more ...
Thiago Mazzu-Nascimento, Débora Gusmão Melo, Giorgio Gianini Morbioli, Emanuel Carrilho, Fernanda Sales Luiz Vianna, André Anjos da Silva, Lavinia Schuler-Faccini   +6 more
doaj   +2 more sources

Comparative analysis of teratogen-induced malformations and gene expression across zebrafish strains in early development [PDF]

Toxicology Reports
Zebrafish embryos are widely used in developmental toxicity testing. However, the extent to which genetic background influences susceptibility to teratogenic compounds remains incompletely understood.
Chitose Taya, Kota Ujibe, Shinnosuke Shimodaira, Aoto Sakamoto, Seiji Wada, Makoto Kashima, Hiromi Hirata   +6 more
doaj   +2 more sources

Developmental Exposures to Three Mammalian Teratogens Produce Dysmorphic Phenotypes in Adult <i>Caenorhabditis elegans</i>. [PDF]

Toxics
Efficient new methods are needed to support initiatives to reduce, refine, and/or replace toxicity testing in vertebrates. 5-fluorouracil (5FU), hydroxyurea (HU), and ribavirin (RV) are mammalian teratogens. Skeletal, endocrine organ, and cardiac effects
Hunt PR, Ferguson M, Olejnik N, Yourick J, Sprando RL.   +4 more
europepmc   +2 more sources

Effects of Multivitamins and Known Teratogens on Chick Cardiomyocytes Micromass Culture Assay [PDF]

Iranian Journal of Basic Medical Sciences, 2013
Objective(s): This study aimed to find out whether the chick cardiomyocyte micromass (MM) system could be employed to predict the teratogenecity of common environmental factors. Different multivitamins and over the counter drugs were used in this study.  
Samreen Memon, Margaret Pratten
doaj   +1 more source

Functional Polymorphisms in the p53 Pathway Genes on the Genetic Susceptibility to Zika Virus Teratogenesis

Frontiers in Cellular and Infection Microbiology, 2021
Congenital Zika Syndrome (CZS) occurs in up to 42% of individuals exposed to ZIKV prenatally. Deregulation in gene expression and protein levels of components of the p53 signaling pathway, such as p53 and MDM2, due to ZIKV infection has been reported ...
Julia A. Gomes, Julia A. Gomes, Julia A. Gomes, Julia A. Gomes, Eduarda Sgarioni, Igor A. Vieira, Igor A. Vieira, Lucas R. Fraga, Lucas R. Fraga, Lucas R. Fraga, Lucas R. Fraga, Patrícia Ashton-Prolla, Patrícia Ashton-Prolla, Ana Cláudia P. Terças-Tretell, Juliana H. da Silva, Bethânia F.R. Ribeiro, Marcial F. Galera, Thalita M. de Oliveira, Maria Denise F. Carvalho de Andrade, Isabella F. Carvalho, Lavínia Schuler-Faccini, Lavínia Schuler-Faccini, Lavínia Schuler-Faccini, Fernanda S. L. Vianna, Fernanda S. L. Vianna, Fernanda S. L. Vianna, Fernanda S. L. Vianna   +26 more
doaj   +1 more source

Teratogenic Effects of Diatom Metabolites on Sea Urchin Paracentrotus lividus Embryos

Marine Drugs, 2010
The diatom-derived polyunsaturated aldehydes (PUAs), 2-trans,4-trans-decadienal, 2-trans,4-trans-octadienal, 2-trans,4-trans,7-octatrienal, 2-trans,4-trans-heptadienal, as well as tridecanal were tested on early and later larval development in the sea ...
Giovanna Romano, Antonio Miralto, Adrianna Ianora   +2 more
doaj   +1 more source

Opportunities and Challenges for Surveillance of Congenital Anomalies in Sub-Saharan Africa. [PDF]

Birth Defects Res
ABSTRACT Introduction Congenital anomalies (CA) are ranked as the 3rd and 4th leading cause of neonatal and under‐5 mortality, respectively. Over 30% of infants born with a serious CA are found in sub‐Saharan Africa. Yet there are few robust epidemiological data on the burden and distribution of CA and associated mortality, disability, and morbidity ...
Kalk E, Malherbe HL, Mehta UC, Mumpe-Mwanja D, Diseko MD, Ayede AI, Kisa P, Osoro CB, Bello G, Fairlie L, Chepkemoi A, Shabani HK, Sie A, Tegene SA, Serunjogi R, Leke AZ, Dolk H, Mosha LB, sub‐Saharan African Congenital Anomalies Network (sSCAN).   +18 more
europepmc   +2 more sources