Results 61 to 70 of about 7,092 (271)

Termination of Pregnancy Following Periconception Isotretinoin Exposure in South Korea

Clinical and Experimental Obstetrics & Gynecology
Background: Despite South Korea’s Ministry of Food and Drug Safety (MFDS) risk management program (RMP) since June 2019, isotretinoin prescriptions have surged 2.5 times from 0.39 million in 2017 to 0.97 million in 2021.
Young-Rae Lee, Dong-Won Hwang, Kyoung-Chul Chun, Young-Ah Kim, Jae-Whoan Koh, Jung-Yeol Han, June-Seek Choi, Hye-Young Kwon   +7 more
doaj   +1 more source

Drug use during pregnancy

Horizonte Médico, 2018
Due to ethical reasons, very scarce clinical assays have been conducted and published. This situation has resulted in the exaggeration of drug risk during pregnancy, thus limiting its reasonable use for chronic diseases in pregnant women.
José Sandoval Paredes, Cindy Sandoval Paz   +1 more
doaj   +1 more source

The effect of antiseizure medications on the exposure to combined oral contraceptives: A systematic review and network meta‐analysis

Epileptic Disorders, EarlyView.
Abstract Objective Current recommendations for prescribing combined oral contraceptives (COCs) to people with epilepsy are often conflicting, particularly for weak inducers of cytochrome P450 3A4. We aimed to critically review the literature and compare the antiseizure medication (ASM)‐induced changes in exposure to COC components.
Hagar Cohen, Amnah Omar Mahajna, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +4 more
wiley   +1 more source

Epilepsy with eyelid myoclonia beyond the classical phenotype: Longitudinal electroclinical observations in a pediatric cohort

Epileptic Disorders, EarlyView.
Abstract Objective Epilepsy with eyelid myoclonia is a childhood‐onset generalized epilepsy syndrome with variable recognition of eyelid myoclonia, eye‐closure sensitivity, and photosensitivity during follow‐up. We aimed to characterize longitudinal clinical and electroencephalographic features in pediatric epilepsy with eyelid myoclonia, focusing on ...
Hande Aygün, Alper Taşkın, Özlem Yayıcı Köken, Şenay Haspolat   +3 more
wiley   +1 more source

Pregnancy Outcome After First-Trimester Exposure to Statins: Study Results Based on the Embryotox Cohort. [PDF]

Pharmacoepidemiol Drug Saf
ABSTRACT Purpose This observational cohort study aimed to assess the risk of adverse pregnancy and neonatal outcomes in pregnancies exposed to statins during the first trimester, given that the use of statins during pregnancy remains controversial. The primary study endpoints were the rates of spontaneous abortion and major birth defects.
Beck E, Adelsberger AT, Dathe K.
europepmc   +2 more sources

A British Pharmacological Society Position Statement on Medications in Pregnancy and Lactation

British Journal of Clinical Pharmacology, EarlyView.
Agnesa Mustafa, Cleodie C. Swire, Reya V. Shah, Bernadette Jenner, Rory H. McLean, Muhammad Shamsher Ahmed, Adrie Bekker, Julia Zöllner, Rachel K. Scott, Robert R. Bies, Sara K. Quinney, Dagan O. Lonsdale, Emma Forton Magavern, Catriona Waitt, Anita Banerjee   +14 more
wiley   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, EarlyView.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Congenital Single Digit Deformities: Series of Cases in Multiple Families in Remote Villages of Haryana

Journal of Surgical Specialties and Rural Practice
Background and Purpose: Congenital deformities occur due to abnormal development of limbs in the intrauterine life. The exact cause of this type of defect is not known but can be associated with environmental factors (drug history or exposure of chemical
Gunjan Upadhyay, Ashish Arya, Ved Prakash Anchal, Santosh Laxmanrao Munde, Ghanapriya Singh, Mitali Kapoor   +5 more
doaj   +1 more source

Valproate, thalidomide and ethyl alcohol alter the migration of HTR-8/SVneo cells

Reproductive Biology and Endocrinology, 2006
Background Valproate, thalidomide and alcohol (ethanol) exposure during the first trimester of pregnancy is known to cause several developmental disorders.
Rout Ujjwal K
doaj   +1 more source

Attitudes toward sodium valproate use, withdrawal, and counseling in people of reproductive potential: A scoping review

Epilepsia Open, EarlyView.
Abstract Regulatory restrictions and evolving clinical guidelines have aimed to reduce sodium valproate use in people of reproductive potential over the past decade due to its teratogenic risk. While clinical evidence and policy responses are well established, stakeholder perspectives remain less explored.
Katherine Wang, Sarah Loveday, Monica S. Cooper, Emma Macdonald‐Laurs   +3 more
wiley   +1 more source