Results 61 to 70 of about 6,483 (296)

Characteristics and temporal trends of EU teratological safety signals and information dissemination to healthcare professionals in the Netherlands—A contribution of the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Although regulatory responses to safety signals have been studied, pregnancy‐specific data and their dissemination to medical professionals remain unclear. This study examined the characteristics and temporal trends of teratological safety signals prompting the European Medicines Agency to implement risk minimization measures.
Yrea R. J. van Rijt‐Weetink, Rosanne E. Huisman, Jan‐Peter van Wieringen, H. J. M. J. (Ineke) Crijns, Florence P. A. M. van Hunsel, Anneke L. M. Passier, Sander Borgsteede, A. C. G. (Toine) Egberts, Laura M. Yates, Eugène P. van Puijenbroek   +9 more
wiley   +1 more source

Women’s Knowledge and Perception of Teratogens and Their Effect in First Trimester of Pregnancy in Antenatal Care Units of Secondary Health Facilities in Kebbi State, Nigeria

, 2020
The study was conducted to evaluate the knowledge and perception of teratogens among pregnant women attending antenatal care units in secondary health facility in kebbi state.
Yahaya, Jafar, Mohammed, Sirajo, Ahmad, Sani   +2 more
core  

A novel low-density lipoprotein receptor-related protein protects against environmental teratogens

, 2021
Congenital malformations are the leading cause of infant mortality in the United States, and 2% of all live births have some form of malformation.
Kuka, Timothy Paul
core  

Congenital Single Digit Deformities: Series of Cases in Multiple Families in Remote Villages of Haryana

Journal of Surgical Specialties and Rural Practice
Background and Purpose: Congenital deformities occur due to abnormal development of limbs in the intrauterine life. The exact cause of this type of defect is not known but can be associated with environmental factors (drug history or exposure of chemical
Gunjan Upadhyay, Ashish Arya, Ved Prakash Anchal, Santosh Laxmanrao Munde, Ghanapriya Singh, Mitali Kapoor   +5 more
doaj   +1 more source

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Sherbet Samuels, Rebecca Racz, Mohamed A. Mohamoud, Nicholas P. Tatonetti   +6 more
wiley   +1 more source

Reducing Exposure Before Birth: An Interrupted Time Series Study of Prenatal Exposure to Fetotoxic Medications Under Risk Management Plans in Canada

Clinical Pharmacology &Therapeutics, EarlyView.
Canada's 2009 risk management plan (RMP) framework has not been evaluated for prenatal exposure impact. Conversely, widely used drugs such as nonsteroidal anti‐inflammatory drugs (NSAIDs) lack RMPs. We assessed first‐trimester exposure to RMP‐regulated medications following regulatory interventions and to NSAIDs following safety publications.
Nahiyan Saiyara Khan, Odile Sheehy, Lisiane Freitas Leal, Vanina Tchuente, Anick Bérard   +4 more
wiley   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

Possible Effects of Immunosuppressive Therapy on Male Fertility and Pregnancy Outcomes After Paternal Exposure in Kidney Transplant Patients

Bezmiâlem Science
Kidney transplantation is a crucial treatment for improving the quality of life of patients with renal failure. Immunosuppressive drugs are necessary to prevent organ rejection and are vital for the success of the transplantation.
Ersan HOROZ, İsmail YILMAZ, Yusuf Özlem İLBEY   +2 more
doaj   +1 more source

Review on the Toxicity and Safety of Medicinal Plants during Pregnancy

Proceedings
Introduction: Although herbs are widely used and considered safe, they can be toxic, especially during pregnancy [...]
Aniket Rajesing Girase, Javesh Kashinath Patil, Devshree Yashwantbhai Patel, Harsha Vasudev Chaudhari, Sachinkumar Madhukar Mahajan   +4 more
doaj   +1 more source

Testicular Histological Changes and Ki-67 Expression in Lead (II) Oxide Toxicity among Neonatal Wistar Rats and Modulatory Role of Retinol [PDF]

Archives of Razi Institute
Lead toxicity has been recognized in soft tissues, whereas retinoid facilitates embryonic development during the intrauterine phase and support tissue regeneration.
Babatunde Dare, Kolawole Blessing, Peter Peter, Ebele Cinderela, Obembe, Olawale, Adeleke Samson   +5 more
doaj   +1 more source