Results 91 to 100 of about 11,254 (283)

Valproic Acid-Induced Syringomyelia in Rat Fetuses

پزشکی بالینی ابن سینا, 2005
Among antiepileptic drugs, valproic acid (VA) is a well known    teratogenic agent. Although axial skeletal malformations (vertebral column) and limb defects have been described, its main target organ is neuroepithelium of neural tube. Therefore it seems
Mohammad Reza Nikravesh, Mahdi Jalali
doaj  

Recombinant methioninase combined with doxorubicin (DOX) regresses a DOX-resistant synovial sarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model. [PDF]

, 2018
Synovial sarcoma (SS) is a recalcitrant subgroup of soft tissue sarcoma (STS). A tumor from a patient with high grade SS from a lower extremity was grown orthotopically in the right biceps femoris muscle of nude mice to establish a patient-derived ...
Dry, Sarah M, Eckardt, Mark A, Eilber, Fritz C, Gainor, Emily, Han, Qinghong, Hayashi, Katsuhiro, Higuchi, Takashi, Hoffman, Robert M, Igarashi, Kentaro, Kawaguchi, Kei, Kimura, Hiroaki, Kiyuna, Tasuku, Li, Shukuan, Li, Yunfeng, Miwa, Shinji, Miyake, Kentaro, Miyake, Masuyo, Nelson, Scott D, Oshiro, Hiromichi, Russell, Tara A, Singh, Arun S, Tan, Yuying, Tsuchiya, Hiroyuki, Yamamoto, Norio   +23 more
core   +2 more sources

Trends in antiseizure medication monotherapy for pediatric epilepsy in the United States

Epilepsia Open, EarlyView.
Abstract Objective National prescribing trends for antiseizure medication (ASM) in children with epilepsy over the past decade are unclear. Despite the 2021 SANAD II trials supporting lamotrigine and valproate for focal and generalized epilepsies, respectively, it is unknown if their use increased.
Adam P. Ostendorf, Mariah Eisner, Mahmoud Abdel‐Rasoul, Stephanie M. Ahrens, Jaime D. Twanow, Howard P. Goodkin, Christopher W. Beatty   +6 more
wiley   +1 more source

Methanol and isopropanol embryo dosage response curves for wild-type and ethanol-sensitive zebrafish [PDF]

, 2016
It is well established that ethanol has an array of negative effects on developing embryos, from craniofacial abnormalities to cognitive deficits and behavioral disorders.
Anderson, Ashley
core   +1 more source

Timing of conception after methotrexate and subsequent pregnancy outcomes: A retrospective cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Methotrexate is widely used to treat ectopic pregnancy (EP). Concerns about its teratogenicity have led to uncertainty regarding the optimal interval before attempting conception. Guidelines recommend a 3‐month washout period, while the manufacturer advises 6 months. Evidence on the safety of early conception is limited.
Bar Rosh, Joul Hadad, Naomi Gronich
wiley   +1 more source

Congenital Single Digit Deformities: Series of Cases in Multiple Families in Remote Villages of Haryana

Journal of Surgical Specialties and Rural Practice
Background and Purpose: Congenital deformities occur due to abnormal development of limbs in the intrauterine life. The exact cause of this type of defect is not known but can be associated with environmental factors (drug history or exposure of chemical
Gunjan Upadhyay, Ashish Arya, Ved Prakash Anchal, Santosh Laxmanrao Munde, Ghanapriya Singh, Mitali Kapoor   +5 more
doaj   +1 more source

TERATOGENIC PROPERTIES OF DRUGS. BACKGROUND INFORMATION

Педиатрическая фармакология, 2013
The article presents the most significant steps in the development of ideas about drugs’ effects on fetus. It features the thalidomide tragedy and features of thalidomide teratogenic properties, as well as data on thalidomide syndrome prevention ...
A. A. Ivanova, A. V. Mikhailov, A. S. Kolbin   +2 more
doaj   +1 more source

The Control of Reproductive Hazards in the Workplace: A Prescription for Prevention [PDF]

, 1983
As workers become more aware that occupational exposure to toxic substances can impair their ability to bring healthy children into the world. they will begin to focus on legal mechanisms for reducing reproductive hazards in the workplace.
Ashford, Nicholas A., Caldart, Charles C.   +1 more
core  

Assessment of Gold‐Mediated Male Reproductive Dysfunction in Male WISTAR Rats Through Sperm Analysis and Testosterone Measurement

Journal of Applied Toxicology, EarlyView.
ABSTRACT Gold has been used for centuries in both ornamental and medicinal contexts. More recently, gold compounds, containing ions or nanoparticles, have attracted attention for their anti‐inflammatory, anticancer, and diagnostic applications. Therefore, concerns about systemic toxicity and biodistribution have prompted investigations into the ...
Samira Maghraoui, Adrian Florea, Leila Tekaya   +2 more
wiley   +1 more source

Differences between NMRI and DBA/2J mice in the development of somites and susceptibility to methylnitrosourea-induced skeleton anomalies [PDF]

, 2017
The development of DBA/2J mouse strain embryos is nearly 12 h - or 6 somite pairs - delayed as compared to the outbred NMRI mouse embryos of the same age on gestation days (GD) 8-12.
Chahoud, Ibrahim, Paumgarttem, Francisco J. R.   +1 more
core   +1 more source