Results 141 to 150 of about 7,092 (271)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, Volume 13, Issue 57, 14 October 2026.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

A Barrier to Understanding Teratogenicity: The Critical Periods of Sensitivity for Most Structural Birth Defects Precede the Established Hemochorial Placenta. [PDF]

Birth Defects Res
Nangle MA, Shah K, Kumar S, Lipinski RJ.
europepmc   +1 more source

Teratogen exposure [PDF]

Ultrasound in Obstetrics & Gynecology, 1994
openaire   +2 more sources

Aqueous Processing of High‐Loading LNMO Electrodes for High‐Energy Lithium Batteries

Advanced Energy and Sustainability Research, Volume 7, Issue 10, October 2026.
High loading LNMO: Aqueous and PFAS‐free high loading LNMO cathodes are produced using multilayer coating technique on industrial pilot line, aiming to bridge the gap between research and industry on sustainable and thick cathode manufacturing. This study shows a method to produce sustainable and high‐performance new generation cathodes.
Buket Boz, Lukas Neidhart, Susan Montes, Carolyn Reinhold, Yuanchun Huang, Wilhelm Pfleging, Stefano Passerini   +6 more
wiley   +1 more source

Risk and Benefit of Drug Use During Pregnancy

International Journal of Medical Sciences, 2005
Environmental teratogenic factors (e.g. alcohol) are preventable. We focus our analysis on human teratogenic drugs which are not used frequently during pregnancy. The previous human teratogenic studies had serious methodological problems, e.g.
doaj  

A case of early diagnosis of alobar holoprosencephaly from Pakistan: importance of prompt prenatal imaging. [PDF]

J Med Case Rep
Qazi R, Liaquat A, Qazi QUA, Tariq B, Usmani SUR.   +4 more
europepmc   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, Volume 2, Issue 5, October 2026.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

FATE-MAP predicts teratogenicity and human gastrulation failure modes by integrating deep learning and mechanistic modeling. [PDF]

Nat Commun
Rufo J, Qiu C, Han D, Baxter N, Daley G, Dhillon J, Wong F, Collins JJ, Wilson MZ.   +8 more
europepmc   +1 more source

Teratogenicity of cocaine

The Journal of Pediatrics, 1987
H, Bauchner, B, Zuckerman, H, Amaro, D A, Frank, S, Parker   +4 more
openaire   +2 more sources

Nanosized Graphene‐Based Hybrid Architectures for Combating Microplastic Pollution From Water: Materials Design, Mechanisms, and Applications

Applied Research, Volume 5, Issue 5, October 2026.
Graphene hybrid architectures (GHAs) have emerged as promising materials for addressing microplastic pollution. Exceptional surface area, tunable chemistry, and synergistic functionalities play key role in GHAs. This review highlights recent advancements in GHAs for microplastic removal, emphasizing their mechanisms, efficiency, and future ...
Chirasmayee Mohanty, Rajesh Kumar Sahoo, Alaka Samal   +2 more
wiley   +1 more source