Results 81 to 90 of about 4,105 (201)

Molecular determinant of substrate binding and specificity of cytochrome P450 2J2

Scientific Reports, 2020
Cytochrome P450 2J2 (CYP2J2) is responsible for the epoxidation of endogenous arachidonic acid, and is involved in the metabolism of exogenous drugs.
Liang Xu, Liao Y. Chen
doaj   +1 more source

Organic Nanovesicular Cargoes for Sustained Drug Delivery: Synthesis, Vesicle Formation, Controlling “Pearling” States, and Terfenadine Loading/Release Studies

Journal of Nanotechnology, 2014
“Sustained drug delivery systems” which are designed to accomplish long-lasting therapeutic effect are one of the challenging topics in the area of nanomedicine.
Ajay Kumar Botcha, Balakrishna Dulla, E. Ramanjaneya Reddy, Keerthana S. Chennubhotla, Pushkar Kulkarni, Rajadurai Chandrasekar, Marina S. Rajadurai   +6 more
doaj   +1 more source

A Comparative Pharmacokinetic-Pharmacodynamic Study of the Electrocardiographic Effects of Epinastine and Terfenadine in Rats

, 1997
The effects of epinastine hydrochloride and terfenadine on electrocardiographic (ECG) parameters in rats were investigated from a pharmacokinetic and pharmacodynamic perspective. Epinastine hydrochloride (1 or 3 mg kg−1 h−1) or terfenadine
Hisakazu Ohtani, Tatsuji Iga, Yasufumi Sawada, Hajime Kotaki   +3 more
core   +1 more source

Electrophysiological Characterization of Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells

Journal of Pharmacological Sciences, 2011
.: Cardiomyocytes derived from human induced pluripotent stem cells (hiPS-CMs) hold great promise for development of in vitro research tools to assess cardiotoxicity, including QT prolongation.
Masaki Honda, Jumpei Kiyokawa, Mitsuyasu Tabo, Tomoaki Inoue   +3 more
doaj   +1 more source

Optimisation of embryonic and larval ECG measurement in zebrafish for quantifying the effect of QT prolonging drugs.

PLoS ONE, 2013
Effective chemical compound toxicity screening is of paramount importance for safe cardiac drug development. Using mammals in preliminary screening for detection of cardiac dysfunction by electrocardiography (ECG) is costly and requires a large number of
Sundeep Singh Dhillon, Eva Dóró, István Magyary, Stuart Egginton, Attila Sík, Ferenc Müller   +5 more
doaj   +1 more source

Molecular Mobility of Terfenadine: Investigation by Dielectric Relaxation Spectroscopy and Molecular Dynamics Simulation

, 2019
The molecular mobility of an amorphous active pharmaceutical ingredient, terfenadine, was carefully investigated by dielectric relaxation spectroscopy and molecular dynamics simulation for the first time.
Jeanne-Annick Bama (7521668), Emeline Dudognon, Frédéric Affouard, Frédéric Affouard (2044834), Jeanne-Annick Bama, Emeline Dudognon (7521665)   +5 more
core   +1 more source

Screening and Identification of Cardioprotective Compounds From Wenxin Keli by Activity Index Approach and in vivo Zebrafish Model

Frontiers in Pharmacology, 2018
Wenxin Keli (WXKL) is a widely used Chinese botanical drug for the treatment of arrhythmia, which is consisted of four herbs and amber. In the present study, we analyzed the chemical composition of WXKL using liquid chromatography coupled with high ...
Hao Liu, Xuechun Chen, Xiaoping Zhao, Buchang Zhao, Ke Qian, Yang Shi, Mirko Baruscotti, Yi Wang   +7 more
doaj   +1 more source

Comparative effects of loratadine and terfenadine in the treatment of chronic idiopathic urticaria.

, 1990
Loratadine is a new selective peripheral histamine H1-receptor antagonist, that is orally effective, long-acting, and devoid of significant central and autonomic nervous system activity.
Belaich, S, Paul, Emmanuelle, Pedrali, P, Bruttmann, G, Tennstedt, Dominique, Lachapelle, Jean-Marie, Degreef, H.   +6 more
core  

Effects of terfenadine and diphenhydramine on the CYP2D6 activity in healthy volunteers

, 2002
The aim of this study was to investigate the effects of two antihistaminic drugs, terfenadine and diphenhydramine on CYP2D6 activity by using debrisoquine as a model substrate.
Selim Kortunay, Kayaalp, SO, Atila Bozkurt, Nursabah E. Basci, Bozkurt, A, S. Oguz Kayaalp, Basci, NURSABAH ELİF, Kortunay, S   +7 more
core   +1 more source

MitoToxy assay: A novel cell-based method for the assessment of metabolic toxicity in a multiwell plate format using a lactate FRET nanosensor, Laconic.

PLoS ONE, 2019
Mitochondrial toxicity is a primary source of pre-clinical drug attrition, black box warning and post-market drug withdrawal. Methods that detect mitochondrial toxicity as early as possible during the drug development process are required.
Yasna Contreras-Baeza, Sebastián Ceballo, Robinson Arce-Molina, Pamela Y Sandoval, Karin Alegría, Luis Felipe Barros, Alejandro San Martín   +6 more
doaj   +1 more source