Results 101 to 110 of about 3,461,095 (294)

Purifying Selection Determines the Short-Term Time Dependency of Evolutionary Rates in SARS-CoV-2 and pH1N1 Influenza. [PDF]

open access: yesMol Biol Evol, 2022
Ghafari M   +6 more
europepmc   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

Nonlinear heat equation with viscoelastic term: Global existence and blowup in finite time

open access: yesDemonstratio Mathematica
In this study, we investigate a nonlinear heat equation incorporating both a viscoelastic term and a reaction-diffusion term that depends on space-time variables.
Vu Ngo Tran, Dung Dao Bao
doaj   +1 more source

CREATING TIME: LONG TERM ON THE SHORT TERM

open access: yes
Text from a blog post on helping students make time for professional development, even when it is busy- and practicing what you preach. On graduation, veterinarians (and the rest of us) are never "done" with work; there is *always* more work to do.
openaire   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

The time validity of Philip's two‐term infiltration equation: An elusive theoretical quantity?

open access: yesVadose Zone Journal
The two‐term infiltration equation I(t)=St+At is commonly used to determine the sorptivity, S (LT−1/2), and product, A=cKs (LT−1), of the dimensionless multiple c and saturated soil hydraulic conductivity Ks (LT−1) from cumulative vertical infiltration ...
Jasper A. Vrugt   +5 more
doaj   +1 more source

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