Evolution of cyclic di-GMP signalling on a short and long term time scale. [PDF]
Microbiology (Reading), 2023 Römling U, Cao LY, Bai FW.
europepmc +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Long Term Time-Lapse Imaging of Geographic Atrophy: A Pilot Study. [PDF]
Front Med (Lausanne), 2022 Paques M +6 more
europepmc +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Short-Term Forecasting of Non-Stationary Time Series
Engineering ProceedingsForecasting climate events is crucial for mitigating and managing risks related to climate change; however, the problem of non-stationarity in time series (NTS) arises, making it difficult to capture and model the underlying trends.
Amir Aieb +3 more
doaj +1 more source
Long-term time trends in reactivated herpes simplex infections and treatment in Sweden. [PDF]
BMC Infect Dis, 2022 Lopatko Lindman K +5 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The time validity of Philip's two‐term infiltration equation: An elusive theoretical quantity?
Vadose Zone JournalThe two‐term infiltration equation I(t)=St+At is commonly used to determine the sorptivity, S (LT−1/2), and product, A=cKs (LT−1), of the dimensionless multiple c and saturated soil hydraulic conductivity Ks (LT−1) from cumulative vertical infiltration ...
Jasper A. Vrugt +5 more
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xLSTMTime: Long-Term Time Series Forecasting with xLSTM
AIIn recent years, transformer-based models have gained prominence in multivariate long-term time series forecasting (LTSF), demonstrating significant advancements despite facing challenges such as high computational demands, difficulty in capturing ...
Musleh Alharthi, Ausif Mahmood
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Development of a long-term time-weighted exposure metric that accounts for missing data in the Seychelles Child Development Study. [PDF]
Neurotoxicology, 2022 Thurston SW +5 more
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