Results 41 to 50 of about 13,494 (218)

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, EarlyView.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source

Evaluation of the morphological particularities of chorionic villi in the intrauterine development of the placenta [PDF]

, 2022
Introduction. Chorionic villi are an important component of the placenta, ensuring the fetus’ normal development. Knowledge of the villous profile in various periods of intrauterine development has major importance in the estimation of the placental ...
Șveț, Victoria
core  

HISTOMORPHOMETRIC AND ENDOTHELIN-1 IMMUNOHISTOCHEMICAL STUDY OF HUMAN PLACENTAL VILLI CORRELATED WITH UMBILICAL CORD COILING INDEX

The Iraqi Journal of Medical Sciences, 2017
Background: Umbilical cord coiling index plays a role in predicting the pregnancy outcome and risk of low birth weight. Endothelin-1 binding sites exist on placental stem villi vessels and trophoblastic layer of the villi.
Hayder J. Mubarak, Sarah A. Ahmed
doaj   +6 more sources

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Histologic changes of the placenta in chronic subcompensated placental insufficiency in women with COVID-19 of moderate severity in the second and third trimesters of pregnancy

Якутский медицинский журнал
The histologic study of placental tissues in women with subcompensated chronic placental insufficiency associated with moderate COVID-19 was conducted.
I. A. Andrievskaya, T. S. Churikova, O. L. Kutepova   +2 more
doaj   +1 more source

Maternal‐Fetal Administration of Risdiplam Partially Rescues the SMNΔ7 Mouse Model of Spinal Muscular Atrophy

Annals of Neurology, EarlyView.
Objective Spinal muscular atrophy (SMA) is caused by deletions or mutations in the survival motor neuron 1 (SMN1) gene and subsequent reduction in the expression of survival motor neuron (SMN) protein. The disease is characterized by degeneration of α motor neurons and subsequent muscle atrophy.
Emma R. Sutton, Ariane Beauvais, Rebecca Yaworski, Hugh J. McMillan, Rashmi Kothary   +4 more
wiley   +1 more source

PATHOMORPHOLOGICAL CHANGES OF THE PLACENTA IN CORONAVIRUS DISEASE (COVID-19) IN PREGNANT WOMEN AT 19-32 WEEKS OF GESTATION

Праці Наукового товариства імені Шевченка. Медичні науки
Introduction. The morphology of the placenta (chorion) changes during pregnancy. Immature intermediate villi formed during the first two trimesters are developmental steps towards the stem villi. A cotyledon is the branching of a single stem villus into
Tetiana Savchuk
doaj   +1 more source

Dietary Glutamine Supplementation Alleviated Rumen Epithelium Oxidative Damage and Apoptosis Induced by Feed Restriction via Maintaining Mitochondrial Homeostasis in Female Yaks

Animal Research and One Health, EarlyView.
Dietary glutamine (Gln) supplementation increased the ATP levels and promoted cell proliferation in the rumen epithelium of feed‐restricted yaks. Besides, Gln inhibited ROS accumulation and reduced oxidative damage and apoptosis in the rumen epithelium of feed‐restricted yaks.
Ziqi Yue, Shanpeng Ke, Liyuan Shi, Rui Hu, Zhisheng Wang, Quanhui Peng, Huawei Zou, Jianxin Xiao, Yahui Jiang, Fali Wu, Yiping Tang   +10 more
wiley   +1 more source

MORPHOGENESIS OF CHORIONIC VILLI IN PREGNANT WOMEN WITH CORONAVIRUS DISEASE (COVID-19)

Неонатологія, хірургія та перинатальна медицина
Villous chorion formation proceeds throughout gestation, encompassing stem, intermediate, and terminal villi. Exposure to adverse factors during pregnancy induces structural chorionic alterations that persist until delivery.
Т. Савчук, І. Лещенко
doaj   +1 more source