Results 121 to 130 of about 51,947 (297)

Probing Hadronic γ-Ray and High-energy Neutrino Emission from Gaia DR2 Star Clusters

The Astrophysical Journal
Young and massive stellar clusters are a potential source of galactic cosmic rays due to at least two acceleration mechanisms. Collective stellar winds from massive stars form a wind-blown bubble with a termination shock at which particle acceleration to
Alison M. W. Mitchell, Giovanni Morlino, Silvia Celli, Stefano Menchiari, Andreas Specovius   +4 more
doaj   +1 more source

A Hydrogen‐Releasing Nanozyme Engineers a Mitochondrial ROS Amplifier for Self‐Sustaining Catalytic Immunotherapy

Advanced Science, EarlyView.
We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi, Jingrui Cao, Tong Wu, Guang Yang, YaWen Yang, Shixin Zhang, Wenwen Su, Hongyu Chu, Yangyang Zhao, Shan Jiang, Qiong Wu, Dongxu Jiao, Fangfang Chen   +12 more
wiley   +1 more source

Modulation of galactic cosmic rays near and beyond the termination shock

, 2020
Measurements at the distant outer heliosphere by the Voyager spacecrafts show that galactic cosmic rays are still strongly modulated even close to the expected location of the termination shock. In this paper, we present a model calculation including the
Bryan M Ball, Ming Zhang
core  

Location of the Termination Shock at Solar Maximum [PDF]

, 2002
During the recent solar maximum, Voyager 1 was beyond 80 AU. Extrapolation of the small gradients of anomalous cosmic rays at solar minimum and the larger gradients at solar maximum indicate that the solar wind termination shock is at ≲ 92 AU at the ...
Stone, E. C., Cummings, A. C.
core  

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Supersonic solar wind ion flows downstream of the termination shock explained by a two-fluid shock model

, 2008
In the view of classic magnetohydrodynamics, it is generally expected that at a shock the supersonic upstream flow is converted into the subsonic downstream flow whereby the increased entropy appears in the increased downstream temperature.
H. J. Fahr, S. V. Chalov
core   +1 more source

In Situ Polyurea Integration for Self‐Healing, Durable Transparent Electromagnetic‐Interference Shielding Film

Advanced Science, EarlyView.
A steric‐hindrance molecular engineering strategy uses dimethyl maleate (DMM) to convert poly(1,4‐butanediol) bis(4‐aminobenzoate) (PBDAB) into a precursor with reduced reactivity via Michael addition, thereby retarding the curing process to form a transparent, ultraflexible, and self‐healable secondary‑amine polyurea (PuSA) with a crosslinked network.
Sinan Zheng, Shanyu Zhao, Gengjiang Yao, Yue Liu, Fei Pan, Mingrui Han, Zecheng Li, Shanbo Li, Jiurong Liu, Na Wu, Zhihui Zeng   +10 more
wiley   +1 more source

The hippocampus contributes to retroactive stimulus associations during trace fear conditioning

iScience
Summary: Binding events that occur at different times are essential for memory formation. In trace fear conditioning, animals associate a tone and footshock despite no temporal overlap. The hippocampus is thought to mediate this learning by maintaining a
Kyle Puhger, Ana P. Crestani, Cassiano R.A. F. Diniz, Brian J. Wiltgen   +3 more
doaj   +1 more source

Replication Data for: "Boundary conditions at the heliospheric termination shock with pickup ions."

The table describes boundary conditions for Pick Up Ions (PUIs) ate the heliospheric termination ...
Roytershteyn, Vadim, Pogorelov, Nikolai, Gedalin, Michael   +2 more
core   +1 more source

Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance

Advanced Science, EarlyView.
Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes, Xiaokang Jin, Miguel A. Campos, Chen Zhou, Xiaoyu Zhang   +4 more
wiley   +1 more source