Results 121 to 130 of about 592,047 (243)

8‐Oxoguanine Modified CircMTUS1 Drives PABPC1 Phase Separation to Promote Gastric Cancer Progression and Cisplatin Resistance via Autophagy

Advanced Science, EarlyView.
ABSTRACT Gastric cancer (GC) is a major global health concern, as its prevention and treatment remain significant challenges. The 8‐oxoguanine (o8G) modification of circRNAs, alongside their capacity to orchestrate liquid‐liquid phase separation (LLPS) and autophagy, plays a pivotal role in driving tumor progression and determining therapeutic outcomes.
Lei Peng, Lurong Li, Zhenghui Zhu, Chenyang Li, Huaiming Sang, Guoxin Zhang, Xuan Li, Yini Dang, Yuanyuan Li   +8 more
wiley   +1 more source

The hippocampus contributes to retroactive stimulus associations during trace fear conditioning

iScience
Summary: Binding events that occur at different times are essential for memory formation. In trace fear conditioning, animals associate a tone and footshock despite no temporal overlap. The hippocampus is thought to mediate this learning by maintaining a
Kyle Puhger, Ana P. Crestani, Cassiano R.A. F. Diniz, Brian J. Wiltgen   +3 more
doaj   +1 more source

Maximizing Nanoscale Disorder in Block Copolymers for Orientation‐Independent SERS Platform Toward Non‐Invasive Diagnostics

Advanced Science, EarlyView.
Maximizing Nanoscale Disorder in Block Copolymers for Orientation‐Independent SERS Platform toward Non‐Invasive Diagnostics is a nature‐inspired strategy that engineers controlled randomness within block copolymer lamellae to achieve optical isotropy without compromising nanoscale periodicity.
Jin Man Kim, Wonsik Kim, Wansun Kim, Yeon‐Hee Kim, Samjin Choi, Jang Hwan Kim, Hyeong Min Jin   +6 more
wiley   +1 more source

Bio‐Inspired Bidirectional Winding Origami With Programmable Modular Reconfigurability and Scalability

Advanced Science, EarlyView.
A bio‐inspired bidirectional‐winding origami platform enables scalable and programmable deployable structures. Double axial folding inspired by earwig hindwings and Flasher‐based hybridization create modular multilayer architectures with diverse attainable winding angles under fixed boundary conditions.
Wenyao Zhang, Chunlong Wang, Mingli Liu, Chuang Shi, Hongwei Guo, Rongqiang Liu   +5 more
wiley   +1 more source

Predictions for New Horizons’ SWAP Measurements Downstream of the Heliospheric Termination Shock

The Astrophysical Journal Letters
Currently ∼62 au from the Sun, the New Horizons spacecraft is en route to the outer heliosphere boundaries. The first boundary it will encounter is the heliospheric termination shock (HTS), where the solar wind ion (SWI) and interstellar pickup ion (PUI)
E. J. Zirnstein, D. J. McComas, B. L. Shrestha, H. A. Elliott, P. C. Brandt, S. A. Stern, A. R. Poppe, J. Parker, E. Provornikova, K. Singer, A. Verbiscer, New Horizons Heliophysics Team   +11 more
doaj   +1 more source

Automated external defibrillator: Rhythm analysis and defibrillation on paediatric out-of-hospital cardiac arrest

Resuscitation Plus
Objective: This study aims to quantify the reliability of automated external defibrillators (AED) in paediatric out-of-hospital cardiac arrests (pOHCA) by evaluating the defibrillation and the shock advisory system efficacy. Furthermore, the relationship
Emma Menant, Delphine Lavignasse, Sarah Ménétré, Jean-Philippe Didon, Xavier Jouven   +4 more
doaj   +1 more source

An Extension of the Dependency Pair Method for Proving Termination of Higher-Order Rewrite Systems [PDF]

, 2001
This paper explores how to extend the dependency pair technique for proving termination of higher-order rewrite systems. We show that the termination property of higher-order rewrite systems can be checked by the non-exsistence of an infinite R-chain ...
SAKAI, Masahiko, WATANABE, Yoshitsugu, SAKABE, Toshiki   +2 more
core  

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

Detecting the Termination Shock and Beyond

, 2007
. Based on Voyager 2 observations, a numerical model of the heliosphere, which includes the mutual interaction of the interstellar medium, solar wind plasma, and interstellar hydrogen, is employed to speculate on the possible crossing of the ...
Chi Wang And, Chi Wang, John W. Belcher
core  

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source