Results 131 to 140 of about 592,047 (243)
Advanced Science, EarlyView.A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang +12 more
wiley +1 more source
Advanced Science, EarlyView.Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong +8 more
wiley +1 more source
Interstellar Pickup Ion Observations to 60 au
The Astrophysical JournalPrior to the Solar Wind Around Pluto (SWAP) observations from New Horizons, the only significant interstellar pickup ion (PUI) observations were taken inside 5.4 au from the Ulysses and 1 au missions.
D. J. McComas +11 more
doaj +1 more source
Advanced Science, EarlyView.Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang +20 more
wiley +1 more source
Extreme and terminal conditions. Shock
Сеченовский вестник, 2010 Modern view on extreme and terminal conditions with special emphasis on etiology, pathogenesis and approaches to treatment are described.
openaire +1 more source
Welfare Analysis of Regulating Mobile Termination Rates in the UK (with an Application to the Orange/T-Mobile Merger) [PDF]
This paper presents results from a calibrated welfare model of the UK mobile telephony market which includes many mobile networks; calls to and from the fixed network; networkbased price discrimination; and call externalities. The analysis focuses on the
Hoernig, Steffen, Harbord, David
core
Estimate of the Location of the Solar wind Termination Shock [PDF]
, 2001 Over the next three years the termination shock is expected to reach its minimum distance from the Sun before moving outward again in response to increased solar wind dynamic pressure during the new solar cycle.
Stone, E. C., Cummings, A. C.
core
CLRe: A Synergistic Dual‐Engine Framework for One‐Step Retrosynthesis Prediction
Advanced Science, EarlyView.CLRe uses a contrastive difficulty score to order pretrained seq2seq fine‐tuning for retrosynthesis. Reaction embeddings define the ranking score, and a cumulative easy‐to‐hard schedule expands from the easiest subset to the full training set while earlier examples remain active.
Tianhao Su +5 more
wiley +1 more source
BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer
Advanced Science, EarlyView.BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu +12 more
wiley +1 more source
Advanced Science, EarlyView.eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin +3 more
wiley +1 more source