Results 131 to 140 of about 50,442 (262)

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

IMAP's Role in Understanding Particle Injection and Energization Throughout the Heliosphere. [PDF]

Space Sci Rev
Cohen CMS, Alterman BL, Baker DN, Bruno A, Bzowski M, Christian ER, Cohen IJ, Dalla S, Dayeh MA, Desai MI, Elliott HA, Giacalone J, Gkioulidou M, Guo F, Horbury T, Kanekal SG, Kowalska-Leszczyńska I, Lee CO, Livadiotis GI, Luhmann JG, Matthaeus WH, McComas DJ, Mitchell JG, Moebius E, Rankin J, Richardson JD, Schwadron NA, Skoug R, Turner D, Zank G, Zirnstein EJ.   +30 more
europepmc   +1 more source

Current Challenges of Transcription Compartmentalization Research

Advanced Science, EarlyView.
Transcription factors, coactivators, and RNA polymerase II assemble into transcription compartments ranging from small, defined complexes to liquid‐like condensates. This review unifies these seemingly competing descriptions along a single continuum and asks what these compartments have been shown to do, and what they have not, revealing that the most ...
Thomas Quail, Sina Wittmann
wiley   +1 more source

Treatment outcomes of acute leukemia during pregnancy at the National Institute of Hematology and Blood Transfusion. [PDF]

Leuk Res Rep
Khanh BQ, Son NH, Nhat NQ, Thuy TT, Huong NTM, Chang NT, Thanh NH.   +6 more
europepmc   +1 more source

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

A comparison of the epidemiology and outcomes of true refractory and recurrent ventricular fibrillation out-of-hospital cardiac arrest: a retrospective study. [PDF]

Resusc Plus
Alhenaki A, Alqudah Z, Kennett T, Dantanarayana A, Williams B, Nehme Z.   +5 more
europepmc   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Colocalized radiofrequency and pulsed field ablation of incessant ventricular tachycardia with suspected intramural circuit in ischaemic cardiomyopathy using a 3.5 mm single-tip catheter under eCPR: a case report. [PDF]

Eur Heart J Case Rep
Borlich M, Groschke S, Delgado López ML, Fichtlscherer S, Iden L.   +4 more
europepmc   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Dynamic changes of dopamine neuron activity and plasticity at different stages of negative reinforcement learning. [PDF]

Proc Natl Acad Sci U S A
Cheng Q, Liu W, Yao L, Xu S, Wei C, Zheng Q, Wu M, Han J, Liu Z, Ren W, Sun Z.   +10 more
europepmc   +1 more source