Results 111 to 120 of about 51,947 (297)

Modulation of Cosmic Rays at and beyond the Heliospheric Termination Shock

, 2020
The modulation of cosmic ray is studied with a numerical model including a solar wind termination shock, a heliosheath and drifts. Results show interesting features caused by the termination shock and the heliosheath which differ markedly for the two ...
M S Potgieter, U W Langner
core  

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

Advanced Science, EarlyView.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang, Qianchun Wang, Keming Li, Guanshuo Hu, Ying Xin, Kai Tang, Bing Hu, Pengyu Du, Renwei Mao, Baohua Ji, Youhua Tan   +10 more
wiley   +1 more source

The Solar Wind Termination Shock and the Outer Heliosphere

, 2004
Beginning in mid-2002, Voyager 1 observed an extended period of field-aligned flows of low energy ions and electrons that was unlike previous observations, suggesting that the spacecraft was in the vicinity of the solar wind termination shock.
Stone, E. C.
core  

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Enhancements of energetic particles near the heliospheric termination shock

, 2003
The spacecraft Voyager 1 is at a distance greater than 85 au from the Sun, in the vicinity of the termination shock that marks the abrupt slowing of the supersonic solar wind and the beginning of the extended and unexplored distant heliosphere.
Frank B. McDonald, Edward C. Stone, McDonald, Frank B., Heikkila, Bryant C., Lal, Nand, William R. Webber, Alan C. Cummings, Webber, William R., Cummings, Alan C., Bryant Heikkila, Nand Lal, Stone, Edward C.   +11 more
core   +1 more source

A Dynamic Risk Control Methodology for Mission-Critical Systems Under Dependent Fault Processes

Mathematics
Industrial systems operating under severe mission environment are frequently confronted with intricate failure behaviors arising from system internal degradation and extrinsic stresses, posing an elevating challenge to system survivability and mission ...
Zijian Kang, Yuhan Ma, Bin Wang, Kaiye Gao   +3 more
doaj   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Passage of a large interplanetary shock from the inner heliosphere to the heliospheric termination shock and beyond: Its effects on cosmic rays at Voyagers 1 and 2 [PDF]

, 2007
Using data from the charged particle telescopes on V1 and V2 we have followed the progress of a large interplanetary shock as it passes V2 at a distance of 79 AU at about 2006.16, then later crosses the heliospheric termination shock finally reaching V1 ...
McDonald, F. B., Stone, E. C., Lal, N., Cummings, A. C., Webber, W. R., Heikkila, B.   +5 more
core  

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Longitudinal variation of the pickup-proton-injection efficiency and rate at the heliospheric termination shock

, 2008
Context. Pickup ions are considered to be the seed population of the anomalous cosmic rays. The acceleration of the pickup ions at the solar wind termination shock depends on the efficiency with which they are injected into the first reflection mode ...
Scherer, K., Potgieter, M.S., K. Scherer, M. S. Potgieter, S. E. S. Ferreira, H. J. Fahr, Fahr, H.J., Ferreira, S.E.S.   +7 more
core   +1 more source