Results 81 to 90 of about 50,442 (262)

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Visualization of Shock Wave Phenomenon around a Sharp Cone Model at Hypersonic Mach Number in a Shock Tunnel using High Speed Schlieren Facility

Journal of Applied Fluid Mechanics, 2019
The flow field around a Sharp cone model configuration has been investigated by means of Schlieren facility in hypersonic shock tunnel. The time dependent evolution of flow around a cone of angle 11.38° with base radius of 150mm has been visualized ...
M. Saiprakash, C. Senthil Kumar, G. K. Sunil, S. P. Rampratap, V. Shanmugam, G. Balu   +5 more
doaj   +2 more sources

Large-scale Field-aligned Flows in the Heliosheath

The Astrophysical Journal
We use a state-of-the-art 3D MHD simulation to show that large-scale thermal pressure gradients in the heliosheath drive suprathermal particles (pickup ions with 1–5 keV) to stream along magnetic field lines faster than the cold bulk solar wind.
Merav Opher, Marc Kornbleuth, Rob Decker, John Richardson, Ethan Bair, Kostas Dialynas, Romina Nikoukar, Matthew E. Hill, Senbei Du, Vladimir Florinski   +9 more
doaj   +1 more source

Two-zone model for the broadband Crab nebula spectrum: microscopic interpretation

EPJ Web of Conferences, 2017
We develop a simple two-zone interpretation of the broadband baseline Crab nebula spectrum between 10−5 eV and ~ 100 TeV by using two distinct log-parabola energetic electrons distributions.
Fraschetti F., Pohl M.
doaj   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

The Gradual Slowing of the Solar Wind in the Outer Heliosphere

The Astrophysical Journal
The solar wind gradually slows with increasing distance from the Sun as interstellar material becomes ionized and picked up by the solar wind. When observing the solar wind in the outer heliosphere, it is difficult to differentiate temporal decreases in ...
Heather A. Elliott, Tae K. Kim, John D. Richardson, Justyna M. Sokół, Bishwas L. Shrestha, Eric J. Zirnstein, David J. McComas, Paweł Swaczyna, Merav Opher, Maher A. Dayeh, Matthew E. Hill, Andrew Poppe, S. Alan Stern, Pontus C. Brandt, Kelsi Singer, Joel Parker, Anne J. Verbiscer, New Horizons Heliophysics Team   +17 more
doaj   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source