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Quantitative essentiality in a reduced genome: a functional, regulatory and structural fitness map [PDF]
Molecular Systems BiologyEssentiality studies have traditionally focused on coding regions, often overlooking other small genetic regulatory elements. To address this, we combined transposon libraries containing promoter or terminator sequences to obtain a high-resolution ...
Samuel Miravet-Verde +4 more
doaj +2 more sources
Synthetic refactor of essential genes decodes functionally constrained sequences in yeast genome
iScience, 2022 Summary: The relationship between gene sequence and function matters for fundamental and practical reasons. Here, yeast essential genes were systematically refactored to identify invariable sequences in the coding and regulatory regions.
Zhenzhen Liang +13 more
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, 2016 The terminator regions of eukaryotes encode functional elements in the 3′ untranslated region (3′-UTR) that influence the 3′-end processing of mRNA, mRNA stability, and translational efficiency, which can modulate protein production.
Akinori Ikeuchi (839299) +7 more
core +4 more sources
Genetic Variability of Long Terminal Repeat Region between HIV-2 Groups Impacts Transcriptional Activity [PDF]
Journal of Virology, 2020 Over 1 million patients are infected with HIV-2, which is often described as an attenuated retroviral infection. Patients frequently have undetectable viremia and evolve at more slowly toward AIDS than HIV-1-infected patients. Several studies have reported a smaller viral reservoir in peripheral blood mononuclear cells in HIV-2-infected patients than ...
Quentin Le Hingrat +9 more
openaire +3 more sources
Identification of Tinomiscium petiolare from Vietnam using the DNA barcode
Труды по прикладной ботанике, генетике и селекции, 2021 Background. Tinomiscium petiolare Hook.f. & Thomson is a medicinal species of the family Menispermaceae. This species is currently being intensively exploited for therapeutic purposes. Precise and rapid identification of T.
B. B. Thinh +5 more
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Scientific Reports, 2021 Theileria equi, an intraerythrocytic protozoan parasite, causes equine piroplasmosis, a disease which negatively impacts the global horse industry. Genetic manipulation is one of the research tools under development as a control method for protozoan ...
Bumduuren Tuvshintulga +8 more
doaj +1 more source
Genetic Analysis of the Carboxy-Terminal Region of the Hepatitis C Virus Core Protein [PDF]
Journal of Virology, 2010 ABSTRACT Hepatitis C virus (HCV) is a liver-tropic pathogen with severe health consequences for infected individuals. Chronic HCV infection can progress to cirrhosis and hepatocellular carcinoma and is a leading indicator for liver transplantation.
Martina, Kopp +3 more
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Reduced efficacy of selection in regions of the Drosophila genome that lack crossing over [PDF]
, 2007 The recombinational environment is predicted to influence patterns of protein sequence evolution through the effects of Hill-Robertson interference among linked sites subject to selection.
Haddrill, Penelope R +9 more
core +4 more sources
Genetic and Functional Characterization of the N-Terminal Region of the Hepatitis C Virus NS2 Protein [PDF]
Journal of Virology, 2013 ABSTRACT The hepatitis C virus (HCV) NS2 protein has dual roles within the HCV life cycle. While well characterized as an autoprotease that cleaves the NS2/NS3 junction, NS2, primarily via its N-terminal region, is also involved in virion morphogenesis.
Cynthia, de la Fuente +2 more
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