Results 71 to 80 of about 398,377 (289)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Applied Sciences, 2019 With the approaching end of Moore’s Law (that the number of transistors in a dense integrated circuit doubles every two years), the logic data density in modern binary digital integrated circuits can hardly be further improved due to the physical ...
Mingqiang Huang +4 more
doaj +1 more source
Orthogonally C∗-Ternary Jordan Homomorphisms and Jordan Derivations: Solution and Stability
Journal of Mathematics, 2022 In this work, by using some orthogonally fixed point theorem, we prove the stability and hyperstability of orthogonally C∗-ternary Jordan homomorphisms between C∗-ternary Banach algebras and orthogonally C∗-ternary Jordan derivations of some functional ...
Vahid Keshavarz, Sedigheh Jahedi
doaj +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
The representation of integers by positive ternary quadratic polynomials
, 2015 An integral quadratic polynomial is called regular if it represents every integer that is represented by the polynomial itself over the reals and over the $p$-adic integers for every prime $p$. It is called complete if it is of the form $Q({\mathbf x} + {
Chan, Wai Kiu, Ricci, James
core +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
On n-ary Hom-Nambu and Hom-Nambu-Lie algebras
, 2010 It is observed that the category of n-ary Hom-Nambu(-Lie) algebras is closed under twisting by self-weak morphisms. Constructions of ternary Hom-Nambu algebras from Hom-associative algebras, Hom-Lie algebras, ternary totally Hom-associative algebras, and
Albert +61 more
core +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source