Results 151 to 160 of about 784 (245)

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

open access: yesiNew Medicine, Volume 2, Issue 1, March 2026.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi   +14 more
wiley   +1 more source

Eocene Tectonic Change in the South Pacific Caused Exhumation of the Transantarctic Mountains in Northern Victoria Land, Antarctica

open access: yesNew Zealand Journal of Geology and Geophysics, Volume 69, Issue 1, March 2026.
Apatite fission‐track and (U‐Th)/He data indicate rapid exhumation of northern Victoria Land at 40–30 Ma, correlating with opening of Adare Trough at 43–28 Ma. Exhumation was greatest close to the Ross Sea, consistent with other regions of the Transantarctic Mountains.
Rupert Sutherland   +2 more
wiley   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

open access: yesMedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang   +7 more
wiley   +1 more source

MXene‐Based Materials: Compositional Engineering for High‐Performance Microwave Absorption

open access: yesRare Metals, Volume 45, Issue 3, March 2026.
ABSTRACT The rapid advancement of aerospace and electronic information technologies has imposed increasingly stringent requirements on microwave absorbing materials (MAMs), such as high absorption efficiency, lightweight, and environmental stability, making the development of advanced MAMs urgent for both civilian and national defense applications ...
Pan‐Pan Zhou   +8 more
wiley   +1 more source

Enhanced CPU Design for SDN Controller. [PDF]

open access: yesMicromachines (Basel)
Bazzi HS   +4 more
europepmc   +1 more source

Leveraging Electrochemical Diversity in Engineering Liquid‐State Ionic Devices for Neuromorphic Computing

open access: yesSmall, Volume 22, Issue 16, 17 March 2026.
Mixed‐ion transport through Å‐scale pores exhibits various functions, including voltage activation, voltage inactivation, nanopulse generation, and synaptic behavior. Our work reveals that one of the fundamental advantages of ionic computing over electronic computingthe diversity of charge carriersdirectly translates into functional diversity in the ...
Yechan Noh, Alex Smolyanitsky
wiley   +1 more source

f‐Block Element‐Based MOF Thin Films: A Platform for Luminescence, Sensing, and Energy Applications

open access: yesSmall, Volume 22, Issue 16, 17 March 2026.
f‐Block element–based metal–organic framework (f‐MOF) thin films offer exceptional potential for luminescent, sensing, and energy‐related applications. This review surveys recent progress in their synthesis, characterization, and functional implementation, emphasizing the diversity of available thin‐film fabrication strategies. The convergence of these
Dong‐Hui Chen, Christof Wöll
wiley   +1 more source

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