Peptide-Based PROTACs: Transitioning from Static Paradigm to a Dynamic Landscape within Targeted Protein Degradation. [PDF]
Lu X, Hu Q.
europepmc +1 more source
Turning Cold Tumors Into Hot Tumors: Implications for Cancer Therapy
Barrier‐defined strategies for cold‐to‐hot tumor conversion. Cold tumors include immune‐desert and immune‐excluded states marked by poor antigen visibility, limited T‐cell priming, stromal or vascular exclusion, metabolic stress and suppressive immune programs.
Xiao Ge +5 more
wiley +1 more source
Progress on a Carbon Nanotube Field-Effect Transistor Integrated Circuit: State of the Art, Challenges, and Evolution. [PDF]
Chen Z +5 more
europepmc +1 more source
Macrophage: Biological Functions, Diseases, and Therapeutic Targets
Macrophages are sentinel innate immune cells that arise from embryonic precursors and bone marrow monocytes, displaying a functional continuum that transcends the classical M1 (pro‐inflammatory)/M2 (anti‐inflammatory) dichotomy. Under homeostatic conditions, balanced M1/M2 polarization preserves tissue integrity by coordinating immune surveillance ...
Bihang Sun +4 more
wiley +1 more source
Perovskite-Graphene Heterostructure Biosensor Integrated with Biotunable Nanoplasmonic Ternary Logic Gate for Ultrasensitive Cytokine Detection. [PDF]
Sun J +7 more
europepmc +1 more source
Amino Acid and Lipid Metabolism in Cancer: Mechanisms and Therapeutic Opportunities
Amino Acid and lipid metabolism in cancer: (A) Regulation of Amino acid transportation and metabolism in cancer. (B) The core organization of lipid metabolic reprogramming in cancer and their functional consequences. ABSTRACT Metabolic reprogramming is a defining feature of cancer and a major contributor to immune escape.
Zixu Wang +4 more
wiley +1 more source
Low-power analog and mixed-signal circuit techniques for next-generation miniature implantable neural interface systems. [PDF]
Zhao L, Jia Y.
europepmc +1 more source
MYC in Oncogenesis and Therapeutic Implications
The MYC oncogene family (c‐MYC, N‐MYC, L‐MYC) functions as a central transcriptional hub orchestrating cancer progression through multiple interconnected pathways. This graphical abstract illustrates MYC's role as a multidimensional regulator positioned at the nexus of tumor microenvironment remodeling, metabolic reprogramming, and therapeutic ...
Na Zhang +5 more
wiley +1 more source
An overview of critical applications of resistive random access memory. [PDF]
Zahoor F +8 more
europepmc +1 more source
Recent Advances in Conjugation Chemistry Expanding the Applications of the DNA Tetrahedron
The tetrahedral DNA nanostructure (TDN) is a promising drug delivery and biosensing platform that can be chemically modified with absolute payload precision. This review highlights explicit conjugation chemistries driving functionalization of the TDN for a broad range of applications, advancing its role in support of next‐generation biomimetic ...
Tyler J. Rutherford +1 more
wiley +1 more source

