Results 91 to 100 of about 798,978 (348)

Comparative analysis of low-frequency vibrational spectra of native and denatured proteins [PDF]

Известия Саратовского университета. Новая серия: Физика
Background and Objectives: Changes in the secondary and tertiary structures of protein molecules during thermal denaturation lead to changes in their vibrational spectra.
Mankova, Anna A., Brandt, Nikolay Nikolaevich, Chikishev, Andrey Yu.   +2 more
doaj   +1 more source

Statistical analysis of protein molecules [PDF]

, 2011
In this paper, entropy and auto-correlation values of main chain dihedral angles of 22,356 protein molecules are calculated and found to lie within a well-specified range for most proteins.
Kushal Shah
core   +1 more source

Protein folding causes an arrest of preprotein translocation into mitochondria in vivo [PDF]

, 1991
With vital yeast cells, a hybrid protein consisting of the amino- terminal third of the precursor to cytochrome b2 and of the entire dihydrofolate reductase was arrested on the import pathway into mitochondria.
Becker, Karin, Guiard, Bernard, Horwich, Arthur, Neupert, Walter, Pfanner, Nikolaus, Schleyer, Manfred, Tropschug, Maximilian, Wienhues, Ulla   +7 more
core   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Interaction Of Calcium Phosphate Nanoparticles With Human Chorionic Gonadotropin Modifies Secondary And Tertiary Protein Structure

Nova Biotechnologica et Chimica, 2015
Calcium phosphate nanoparticles (CaPNP) have good biocompatibility and bioactivity inside human body. In this study, the interaction between CaPNP and human chorionic gonadotropin (hCG) was analyzed to determine the changes in the protein structure in ...
Al-Hakeim Hussein K, Al-Zabeba Rahman S., Grulke Eric, Jaffar Al-Mulla Emad A.   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Structural role of the tyrosine residues of cytochrome c [PDF]

, 1982
The tertiary structures of horse, tuna, Neurospora crassa, horse [Hse65,Leu67]- and horse [Hse65,Leu74]-cytochromes c were studied with high-resolution 1H n.m.r. spectroscopy.
Boon, Peter J., Brinkhof, Herman H. K., Eley, Crispin G. S., Moore, Geoffrey R., Neupert, Walter, Nivard, Rutger J. F., Tesser, Godefridus I., Williams, Robert J. P.   +7 more
core  

Molecular dynamics simulation of polymer helix formation using rigid-link methods

, 2002
Molecular dynamics simulations are used to study structure formation in simple model polymer chains that are subject to excluded volume and torsional interactions.
A. Dullweber, A. Jain, A. Jain, A. Jain, B. L. de Groot, C. L. Brooks III, D. C. Rapaport, D. C. Rapaport, D. J. Evans, E. I. Shakhnovich, E. M. Boczko, G. Ciccotti, G. M. Crippen, G. Rodriguez, H. C. Anderson, H. J. C. Berendsen, J. C. Nelson, J.-P. Ryckaert, K. A. Dill, L. Verlet, M. Levitt, R. A. Bertsch, R. Edberg, V. S. Pande, Y. Duan, Y. Ueda, Y. Zhou, Y. Zhou   +27 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source