Results 21 to 30 of about 258,881 (309)

Use of the 2D ¹H-¹³C HSQC NMR Methyl Region to Evaluate the Higher Order Structural Integrity of Biopharmaceuticals

Molecules, 2021
The higher-order structure (HOS) of protein therapeutics is directly related to the function and represents a critical quality attribute. Currently, the HOS of protein therapeutics is characterized by methods with low to medium structural resolution ...
Tsang-Lin Hwang, Dipanwita Batabyal, Nicholas Knutson, Mats Wikström   +3 more
doaj   +1 more source

Loop Entropy Assists Tertiary Order: Loopy Stabilization of Stacking Motifs

Entropy, 2011
The free energy of an RNA fold is a combination of favorable base pairing and stacking interactions competing with entropic costs of forming loops. Here we show how loop entropy, surprisingly, can promote tertiary order.
Daniel P. Aalberts
doaj   +1 more source

Structural and Functional Exploration of UTS2B Gene for a Possible Role in Poultry Ascites Syndrome: In Silico Analysis [PDF]

Poultry Science Journal
Ascites syndrome is a multifactorial disease in poultry, associated with high mortality and significant economic losses. Genomic studies have identified UTS2B gene as a candidate gene associated with ascites syndrome in poultry.
Mostafa Ghaderi-Zefrehei, Effat Nasre Esfahani, Hamed Sharyarpour, Mustafa Muhaghegh Dolatabay   +3 more
doaj   +1 more source

Morphology of sodium deoxycholate-solubilized apolipoprotein B-100 using negative stain and vitreous ice electron microscopy

Journal of Lipid Research, 2000
The primary and secondary structures of apolipoprotein B-100 (apoB-100) are well established. Previous morphological studies have suggested that apoB is a long, flexible, threadlike molecule that encircles the low density lipoprotein (LDL) particle ...
Donald L. Gantz, Mary T. Walsh, Donald M. Small   +2 more
doaj   +1 more source

STRUCTURAL SIMILARITY OF CheY-LIKE PROTEINS

TASK Quarterly, 2016
The problem of structural similarity of polypeptide chains of low sequence similarity representing a similar 3D structural form has been the object of analysis of researchers engaged in the protein folding problem.
MATEUSZ BANACH, LESZEK KONIECZNY, IRENA ROTERMAN   +2 more
doaj   +1 more source

Structural 3D Domain Reconstruction of the RNA Genome from Viruses with Secondary Structure Models

Viruses, 2021
Three-dimensional RNA domain reconstruction is important for the assembly, disassembly and delivery functionalities of a packed proteinaceus capsid. However, to date, the self-association of RNA molecules is still an open problem. Recent chemical probing
Simón Poblete, Horacio V. Guzman
doaj   +1 more source

Identification of a novel porcine Teschovirus 2 strain as causative agent of encephalomyelitis in suckling piglets with high mortality in China

BMC Veterinary Research, 2023
Background Porcine Teschovirus (PTV), also named Teschovirus A, is prevalent in pig populations, mainly causing neurological symptoms, diarrhea, pneumonia, and reproductive failure, however the morbidity and mortality are usually low in pig farms.
Wenqi Liang, Xiangdong Wu, Zhen Ding, Shengwei Zhong, Xinjie Qian, Pei Ye, Hao Liu, Zheng Chen, Jinhua Zhang, Huabin Cao, Guoliang Hu, Junrong Luo, Zuohua Li, Nengshui Ding, Ruiming Hu   +14 more
doaj   +1 more source

The gene signature of tertiary lymphoid structures within ovarian cancer predicts the prognosis and immunotherapy benefit

Frontiers in Genetics, 2023
Ovarian cancer (OC) has the lowest survival rate among gynecologic malignancies. Ectopic lymphocyte aggregates, namely tertiary lymphoid structures (TLSs), have been reported as positive biomarkers for tumor prognosis. However, the related gene signature
Yue Hou, Yue Hou, Yue Hou, Yue Hou, Sijing Qiao, Sijing Qiao, Sijing Qiao, Sijing Qiao, Miao Li, Miao Li, Miao Li, Miao Li, Xue Han, Xue Han, Xue Han, Xue Han, Xuan Wei, Xuan Wei, Xuan Wei, Xuan Wei, Yingxin Pang, Yingxin Pang, Yingxin Pang, Yingxin Pang, Hongluan Mao, Hongluan Mao, Hongluan Mao, Hongluan Mao   +27 more
doaj   +1 more source

Recent Progress of Tertiary Lymphoid Structure in Prognosis and Immunotherapy of Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2023
Lung cancer is the leading cause of cancer death, and non-small cell lung cancer (NSCLC) accounts for 85%. Immunotherapy has significantly improved the clinical prognosis of patients with NSCLC. However, because of the complexity and heterogeneousness of
Ying LIU, Lei XIONG, Ruoxue CAI, Yue CHEN, Jinjun YE, Bo SHEN, Guoren ZHOU   +6 more
doaj   +1 more source

CRISPR-Cas-Docker: web-based in silico docking and machine learning-based classification of crRNAs with Cas proteins

BMC Bioinformatics, 2023
Background CRISPR-Cas-Docker is a web server for in silico docking experiments with CRISPR RNAs (crRNAs) and Cas proteins. This web server aims at providing experimentalists with the optimal crRNA-Cas pair predicted computationally when prokaryotic ...
Ho-min Park, Jongbum Won, Yunseol Park, Esla Timothy Anzaku, Joris Vankerschaver, Arnout Van Messem, Wesley De Neve, Hyunjin Shim   +7 more
doaj   +1 more source