Results 41 to 50 of about 291,656 (309)

The gene signature of tertiary lymphoid structures within ovarian cancer predicts the prognosis and immunotherapy benefit

Frontiers in Genetics, 2023
Ovarian cancer (OC) has the lowest survival rate among gynecologic malignancies. Ectopic lymphocyte aggregates, namely tertiary lymphoid structures (TLSs), have been reported as positive biomarkers for tumor prognosis. However, the related gene signature
Yue Hou, Yue Hou, Yue Hou, Yue Hou, Sijing Qiao, Sijing Qiao, Sijing Qiao, Sijing Qiao, Miao Li, Miao Li, Miao Li, Miao Li, Xue Han, Xue Han, Xue Han, Xue Han, Xuan Wei, Xuan Wei, Xuan Wei, Xuan Wei, Yingxin Pang, Yingxin Pang, Yingxin Pang, Yingxin Pang, Hongluan Mao, Hongluan Mao, Hongluan Mao, Hongluan Mao   +27 more
doaj   +1 more source

HIGH-THROUGHPUT METHODS FOR INTERROGATION OF RNA TERTIARY STRUCTURE

, 2021
RNAs encode information in not only primary sequence but also higher orderstructure. Transcriptome-level investigations of RNA structure and function by chemicalprobing have been largely limited to secondary structure, as current probing methodslack the ...
Ehrhardt, Jeffrey
core   +1 more source

Recent Progress of Tertiary Lymphoid Structure in Prognosis and Immunotherapy of Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2023
Lung cancer is the leading cause of cancer death, and non-small cell lung cancer (NSCLC) accounts for 85%. Immunotherapy has significantly improved the clinical prognosis of patients with NSCLC. However, because of the complexity and heterogeneousness of
Ying LIU, Lei XIONG, Ruoxue CAI, Yue CHEN, Jinjun YE, Bo SHEN, Guoren ZHOU   +6 more
doaj   +1 more source

Influence of ground-state structure and Mg2+ binding on folding kinetics of the guanine-sensing riboswitch aptamer domain

, 2011
Riboswitch RNAs fold into complex tertiary structures upon binding to their cognate ligand. Ligand recognition is accomplished by key residues in the binding pocket.
Julia Wirmer-Bartoschek, Anna Wacker, Wirmer-Bartoschek, J., Schwalbe, H., Wacker, A., Wirmer-Bartoschek, Julia, Eberhart Warkentin, Buck, Janina, Warkentin, E., Wacker, Anna, Wöhnert, Jens, Schwalbe, Harald, Harald Schwalbe, Wöhnert, J., Jens Wöhnert, Warkentin, Eberhart, Buck, J., Janina Buck   +17 more
core   +1 more source

Oxidation of tertiary amine-derivatized surfaces to control protein adhesion [PDF]

, 2013
Selective oxidation of omega-tertiary amine self-assembled thiol monolayers to tertiary amine N-oxides is shown to transform the adhesion of model proteins lysozyme and fibrinogen upon them.
Evans, Stephen D., Cooper, Amy L., Taylor, Paul C., Biggs, Caroline I., Randev, Rajan K., Fox, David J., Stec, Helena M., Marsh, Andrew, Dowson, Christopher G., Johnson, Benjamin R., Dobrzanska, Dorota A., Randev, Rajan, Cooper, A. (Amy)   +12 more
core   +1 more source

CRISPR-Cas-Docker: web-based in silico docking and machine learning-based classification of crRNAs with Cas proteins

BMC Bioinformatics, 2023
Background CRISPR-Cas-Docker is a web server for in silico docking experiments with CRISPR RNAs (crRNAs) and Cas proteins. This web server aims at providing experimentalists with the optimal crRNA-Cas pair predicted computationally when prokaryotic ...
Ho-min Park, Jongbum Won, Yunseol Park, Esla Timothy Anzaku, Joris Vankerschaver, Arnout Van Messem, Wesley De Neve, Hyunjin Shim   +7 more
doaj   +1 more source

Using neural networks and evolutionary information in decoy discrimination for protein tertiary structure prediction

, 2008
Background: We present a novel method of protein fold decoy discrimination using machine learning, more specifically using neural networks. Here, decoy discrimination is represented as a machine learning problem, where neural networks are used to learn ...
Jones, DT, Tan Ching-Wai, Jones David T, Tan, CW   +3 more
core   +1 more source

Helical domains that mediate lipid solubilization and ABCA1-specific cholesterol efflux in apolipoproteins C-I and A-II[S]

Journal of Lipid Research, 2013
Many of the apolipoproteins in HDL can elicit cholesterol efflux via ABCA1, a critical initial step in HDL formation. Recent work has indicated that omnipresent amphipathic helices play a critical role, and these have been studied intensively in the most
Loren E. Smith, Jere P. Segrest, W. Sean Davidson   +2 more
doaj   +1 more source

The Impact of Programmed Cell Death on the Formation of Tertiary Lymphoid Structures

Frontiers in Immunology, 2021
Tertiary lymphoid structures are clusters of lymphoid tissue that develop post-natally at sites of chronic inflammation. They have been described in association with infection, autoimmune disorders, cancer, and allograft rejection. In their mature stage,
Mélanie Dieudé, Mélanie Dieudé, Mélanie Dieudé, Imane Kaci, Imane Kaci, Imane Kaci, Marie-Josée Hébert, Marie-Josée Hébert, Marie-Josée Hébert   +8 more
doaj   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source