Results 61 to 70 of about 291,656 (309)

Inducible Tertiary Lymphoid Structures: Promise and Challenges for Translating a New Class of Immunotherapy

Frontiers in Immunology, 2021
Tertiary lymphoid structures (TLS) are ectopically formed aggregates of organized lymphocytes and antigen-presenting cells that occur in solid tissues as part of a chronic inflammation response.
Shota Aoyama, Ryosuke Nakagawa, James J. Mulé, James J. Mulé, Adam W. Mailloux   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

CORRELATED MUTATIONS IN SELECTED PROTEIN FAMILIES

TASK Quarterly, 2002
Four different protein families (two proteinase inhibitor families, myoglobins and lysozymes) were surveyed for correlated mutations with respect to the position distance and their significance in structure stabilization and biological activity.
JACEK LELUK, MONIKA SOBCZYK, ŁUKASZ BECELLA   +2 more
doaj  

Tertiary structure of NS3 protease.

, 2014
The crystal structure of the West Nile protease (PDB code 3e90) was taken as a template for homology modeling. (A) The tertiary structure of NS3/NS2B for the pathogenic strain Dalnegorsk. (B) The tertiary structure of NS3/NS2B for the Sfd strain Primorye-
Sergei I. Belikov (552980), Galina N. Leonova (552982), Ilya G. Kondratov (213406), Ulyana V. Potapova (552981)   +3 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Protective role of salt in catalysis and maintaining structure of halophilic proteins against denaturation

Frontiers in Microbiology, 2014
Search for new enzymes of industrial relevance, bestowed with novel properties continues to be a desirable pursuit in enzyme research. Halophilism is the unusual existence of life in saline/ hypersaline habitats and haloenzymes, are the proteins from ...
Rajeshwari eSinha, Sunil Kumar Khare
doaj   +1 more source

Refinement of Protein Tertiary Structure by Using Spin-Spin Coupling Constants from Nuclear Magnetic Resonance Measurements

, 2012
Modelling protein structure seems a challenging enterprise because the number of structure parameters required ordinarily exceeds the amount of independent data points available from experimental observations. Expressing the predominant conformation of a
Schmidt, Jürgen M., Frank Lhr, Jrgen M., Jürgen M. Schmidt, Löhr, Frank, Frank Löhr   +5 more
core   +1 more source

Improved RNA secondary structure and tertiary base-pairing prediction using evolutionary profile, mutational coupling and two-dimensional transfer learning

, 2021
MOTIVATION: The recent discovery of numerous non-coding RNAs (long non-coding RNAs, in particular) has transformed our perception about the roles of RNAs in living organisms.
Jaswinder Singh, Thomas Litfin, Singh, Jaspreet, Zhou, Yaoqi, Jaspreet Singh, Yaoqi Zhou, Litfin, Thomas, Kuldip Paliwal, Paliwal, Kuldip, Tongchuan Zhang, Zhang, Tongchuan, Singh, Jaswinder   +11 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A Novel Structural Measure Separating Non-Coding RNAs from Genomic Backgrounds

Tsinghua Science and Technology, 2015
RNA secondary structure has become the most exploitable feature for ab initio detection of non-coding RNA (ncRNA) genes from genome sequences. Previous work has used Minimum Free Energy (MFE) based methods developed to identify ncRNAs by measuring ...
Yingfeng Wang, Russell L. Malmberg, Liming Cai   +2 more
doaj   +1 more source