Results 31 to 40 of about 291,656 (309)

Disruption of the C-terminal helix by single amino acid deletion is directly responsible for impaired cholesterol efflux ability of apolipoprotein A-I Nichinan

Journal of Lipid Research, 2010
Apolipoprotein A-I (apoA-I) Nichinan, a naturally occurring variant with ΔE235 in the C terminus, is associated with low plasma HDL levels. Here, we investigated the tertiary structure, lipid-binding properties, and ability to induce cellular cholesterol
Momoe Kono, Toshitaka Tanaka, Masafumi Tanaka, Charulatha Vedhachalam, Palaniappan S. Chetty, David Nguyen, Padmaja Dhanasekaran, Sissel Lund-Katz, Michael C. Phillips, Hiroyuki Saito   +9 more
doaj   +1 more source

Biological Significance of the Genomic Variation and Structural Dynamics of SARS-CoV-2 B.1.617

Frontiers in Microbiology, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have been emerging and circulating globally since the start of the COVID-19 pandemic, of which B.1.617 lineage that was first reported in India at the end of 2020, soon became ...
Lin-qian Fan, Xiao-yun Hu, Yi-yue Chen, Xiang-lei Peng, Yuan-hui Fu, Yan-peng Zheng, Jie-mei Yu, Jin-sheng He   +7 more
doaj   +1 more source

Use of the 2D ¹H-¹³C HSQC NMR Methyl Region to Evaluate the Higher Order Structural Integrity of Biopharmaceuticals

Molecules, 2021
The higher-order structure (HOS) of protein therapeutics is directly related to the function and represents a critical quality attribute. Currently, the HOS of protein therapeutics is characterized by methods with low to medium structural resolution ...
Tsang-Lin Hwang, Dipanwita Batabyal, Nicholas Knutson, Mats Wikström   +3 more
doaj   +1 more source

Loop Entropy Assists Tertiary Order: Loopy Stabilization of Stacking Motifs

Entropy, 2011
The free energy of an RNA fold is a combination of favorable base pairing and stacking interactions competing with entropic costs of forming loops. Here we show how loop entropy, surprisingly, can promote tertiary order.
Daniel P. Aalberts
doaj   +1 more source

Structural and Functional Exploration of UTS2B Gene for a Possible Role in Poultry Ascites Syndrome: In Silico Analysis [PDF]

Poultry Science Journal
Ascites syndrome is a multifactorial disease in poultry, associated with high mortality and significant economic losses. Genomic studies have identified UTS2B gene as a candidate gene associated with ascites syndrome in poultry.
Mostafa Ghaderi-Zefrehei, Effat Nasre Esfahani, Hamed Sharyarpour, Mustafa Muhaghegh Dolatabay   +3 more
doaj   +1 more source

Morphology of sodium deoxycholate-solubilized apolipoprotein B-100 using negative stain and vitreous ice electron microscopy

Journal of Lipid Research, 2000
The primary and secondary structures of apolipoprotein B-100 (apoB-100) are well established. Previous morphological studies have suggested that apoB is a long, flexible, threadlike molecule that encircles the low density lipoprotein (LDL) particle ...
Donald L. Gantz, Mary T. Walsh, Donald M. Small   +2 more
doaj   +1 more source

STRUCTURAL SIMILARITY OF CheY-LIKE PROTEINS

TASK Quarterly, 2016
The problem of structural similarity of polypeptide chains of low sequence similarity representing a similar 3D structural form has been the object of analysis of researchers engaged in the protein folding problem.
MATEUSZ BANACH, LESZEK KONIECZNY, IRENA ROTERMAN   +2 more
doaj   +1 more source

Structural 3D Domain Reconstruction of the RNA Genome from Viruses with Secondary Structure Models

Viruses, 2021
Three-dimensional RNA domain reconstruction is important for the assembly, disassembly and delivery functionalities of a packed proteinaceus capsid. However, to date, the self-association of RNA molecules is still an open problem. Recent chemical probing
Simón Poblete, Horacio V. Guzman
doaj   +1 more source

Promoting reflection in asynchronous virtual learning spaces: tertiary distance tutors’ conceptions. [PDF]

, 2014
Increasingly, universities are embedding reflective activities into the curriculum. With the growth in online tertiary education, how effectively is reflection being promoted or used in online learning spaces?
Richardson, John T. E., Linda Price, Price, Linda, Richardson, John T E, John T. E. Richardson, Bethany Alden Rivers, Alden Rivers, Bethany   +6 more
core   +1 more source

Identification of a novel porcine Teschovirus 2 strain as causative agent of encephalomyelitis in suckling piglets with high mortality in China

BMC Veterinary Research, 2023
Background Porcine Teschovirus (PTV), also named Teschovirus A, is prevalent in pig populations, mainly causing neurological symptoms, diarrhea, pneumonia, and reproductive failure, however the morbidity and mortality are usually low in pig farms.
Wenqi Liang, Xiangdong Wu, Zhen Ding, Shengwei Zhong, Xinjie Qian, Pei Ye, Hao Liu, Zheng Chen, Jinhua Zhang, Huabin Cao, Guoliang Hu, Junrong Luo, Zuohua Li, Nengshui Ding, Ruiming Hu   +14 more
doaj   +1 more source