Results 31 to 40 of about 798,978 (348)

Structural 3D Domain Reconstruction of the RNA Genome from Viruses with Secondary Structure Models

Viruses, 2021
Three-dimensional RNA domain reconstruction is important for the assembly, disassembly and delivery functionalities of a packed proteinaceus capsid. However, to date, the self-association of RNA molecules is still an open problem. Recent chemical probing
Simón Poblete, Horacio V. Guzman
doaj   +1 more source

Stabilisation of Na,K-ATPase structure by the cardiotonic steroid ouabain [PDF]

, 2013
Cardiotonic steroids such as ouabain bind with high affinity to the membrane-bound cation-transporting P-type Na,K-ATPase, leading to complete inhibition of the enzyme.
Abdul-Gader, Andrew J. Miles, B.A. Wallace, Esmann, Esmann, Esmann, Esmann, Fedosova, Kabsch, Kaplan, Klodos, Klose, Lees, Lowry, Mikael Esmann, Miles, Miles, Miles, Miles, Morth, Natalya U. Fedosova, Ogawa, Provencher, Schoner, Shinoda, Skou, Sreerama, Søren V. Hoffmann, Van Stokkum, Whitmore, Yatime   +30 more
core   +1 more source

Identification of a novel porcine Teschovirus 2 strain as causative agent of encephalomyelitis in suckling piglets with high mortality in China

BMC Veterinary Research, 2023
Background Porcine Teschovirus (PTV), also named Teschovirus A, is prevalent in pig populations, mainly causing neurological symptoms, diarrhea, pneumonia, and reproductive failure, however the morbidity and mortality are usually low in pig farms.
Wenqi Liang, Xiangdong Wu, Zhen Ding, Shengwei Zhong, Xinjie Qian, Pei Ye, Hao Liu, Zheng Chen, Jinhua Zhang, Huabin Cao, Guoliang Hu, Junrong Luo, Zuohua Li, Nengshui Ding, Ruiming Hu   +14 more
doaj   +1 more source

Recent Progress of Tertiary Lymphoid Structure in Prognosis and Immunotherapy of Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2023
Lung cancer is the leading cause of cancer death, and non-small cell lung cancer (NSCLC) accounts for 85%. Immunotherapy has significantly improved the clinical prognosis of patients with NSCLC. However, because of the complexity and heterogeneousness of
Ying LIU, Lei XIONG, Ruoxue CAI, Yue CHEN, Jinjun YE, Bo SHEN, Guoren ZHOU   +6 more
doaj   +1 more source

The gene signature of tertiary lymphoid structures within ovarian cancer predicts the prognosis and immunotherapy benefit

Frontiers in Genetics, 2023
Ovarian cancer (OC) has the lowest survival rate among gynecologic malignancies. Ectopic lymphocyte aggregates, namely tertiary lymphoid structures (TLSs), have been reported as positive biomarkers for tumor prognosis. However, the related gene signature
Yue Hou, Yue Hou, Yue Hou, Yue Hou, Sijing Qiao, Sijing Qiao, Sijing Qiao, Sijing Qiao, Miao Li, Miao Li, Miao Li, Miao Li, Xue Han, Xue Han, Xue Han, Xue Han, Xuan Wei, Xuan Wei, Xuan Wei, Xuan Wei, Yingxin Pang, Yingxin Pang, Yingxin Pang, Yingxin Pang, Hongluan Mao, Hongluan Mao, Hongluan Mao, Hongluan Mao   +27 more
doaj   +1 more source

Statistical mechanics of RNA folding: a lattice approach [PDF]

, 2003
We propose a lattice model for RNA based on a self-interacting two-tolerant trail. Self-avoidance and elements of tertiary structure are taken into account.
A. Pagnani, B. Derrida, C. Vanderzande, D. Marenduzzo, D.S. Gaunt, E. Carlon, E. Orlandini, F. Krzakala, H. Orland, H.A. Lim, I. Tinoco, J. Chahine, J. Liphardt, J.A. Marqusee, J.S. McCaskill, K. De’Bell, M. Müller, M.C. Tesi, M.S. Causo, N. Madras, P. Grassberger, P. Leoni, P.G. Higgs, P.G. Higgs, R. Bundschuh, R. Bundschuh, R. Bundschuh, S. Cocco, S. Doniach, T.R. Strick, Y. Kafri   +30 more
core   +1 more source

Tertiary Lymphoid Structures: Autoimmunity Goes Local [PDF]

Frontiers in Immunology, 2018
Tertiary lymphoid structures (TLS) are frequently observed in target organs of autoimmune diseases. TLS present features of secondary lymphoid organs such as segregated T and B cell zones, presence of follicular dendritic cell networks, high endothelial venules and specialized lymphoid fibroblasts and display the mechanisms to support local adaptive ...
Elena Pipi, Elena Pipi, Saba Nayar, David H. Gardner, Serena Colafrancesco, Charlotte Smith, Francesca Barone   +6 more
openaire   +4 more sources

CRISPR-Cas-Docker: web-based in silico docking and machine learning-based classification of crRNAs with Cas proteins

BMC Bioinformatics, 2023
Background CRISPR-Cas-Docker is a web server for in silico docking experiments with CRISPR RNAs (crRNAs) and Cas proteins. This web server aims at providing experimentalists with the optimal crRNA-Cas pair predicted computationally when prokaryotic ...
Ho-min Park, Jongbum Won, Yunseol Park, Esla Timothy Anzaku, Joris Vankerschaver, Arnout Van Messem, Wesley De Neve, Hyunjin Shim   +7 more
doaj   +1 more source

The Impact of Programmed Cell Death on the Formation of Tertiary Lymphoid Structures

Frontiers in Immunology, 2021
Tertiary lymphoid structures are clusters of lymphoid tissue that develop post-natally at sites of chronic inflammation. They have been described in association with infection, autoimmune disorders, cancer, and allograft rejection. In their mature stage,
Mélanie Dieudé, Mélanie Dieudé, Mélanie Dieudé, Imane Kaci, Imane Kaci, Imane Kaci, Marie-Josée Hébert, Marie-Josée Hébert, Marie-Josée Hébert   +8 more
doaj   +1 more source

Why Do Proteins Look Like Proteins?

, 1996
Protein structures in nature often exhibit a high degree of regularity (secondary structures, tertiary symmetries, etc.) absent in random compact conformations.
Helling, Robert, Li, Hao, Tang, Chao, Wingreen, Ned   +3 more
core   +1 more source