Results 81 to 90 of about 2,879 (174)
Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis [PDF]
, 2017 Genetic alterations conferring resistance to the effects of chemical inhibitors are valuable tools for validating on-target effects in cells. Unfortunately, for many therapeutic targets such alleles are not available.
Arai, E. +7 more
core +1 more source
Biomimetic Triplet Messenger RNA Formulation in MXene Hydrogel Microneedles for Wound Healing
Aggregate, Volume 6, Issue 2, February 2025.The current direction in the messenger RNA (mRNA) field is focused on imparting mRNA with competitive synthetic functions and delicating carrier systems. By leveraging advanced artificial intelligence technology, a novel triplet mRNA formulation has been developed and delivered via photothermal‐responsive microneedles for the treatment of diabetic ...
Ji Wang +6 more
wiley +1 more source
Pesquisa Veterinária Brasileira, 2015 Porcine teschovirus (PTV), porcine sapelovirus (PSV), and enterovirus G (EV-G) are infectious agents specific to pig host species that are endemically spread worldwide.
Daiane G. Donin +4 more
doaj +1 more source
Steric regulation of tandem calponin homology domain actin-binding affinity. [PDF]
, 2019 Tandem calponin homology (CH1-CH2) domains are common actin-binding domains in proteins that interact with and organize the actin cytoskeleton. Despite regions of high sequence similarity, CH1-CH2 domains can have remarkably different actin-binding ...
Bausch, Andreas +6 more
core +1 more source
mLife, Volume 4, Issue 1, Page 55-69, February 2025.Abstract The global dissemination of H5 avian influenza viruses represents a significant threat to both human and animal health. In this study, we conducted a genome‐wide siRNA library screening against the highly pathogenic H5N1 influenza virus, leading us to the identification of 457 cellular cofactors (441 proviral factors and 16 antiviral factors ...
Guangwen Wang +15 more
wiley +1 more source
FGF8 coordinates tissue elongation and cell epithelialization during early kidney tubulogenesis. [PDF]
, 2015 胚成長と連動する管組織形成メカニズムの解明 －臓器不全治療や再生医療に期待－. 京都大学プレスリリース. 2015-07-03.When a tubular structure forms during early embryogenesis, tubular elongation and lumen formation (epithelialization) proceed simultaneously in a spatiotemporally coordinated manner. We here
Atsuta, Yuji, Takahashi, Yoshiko
core +3 more sources
Unique Characteristics of a Picornavirus Internal Ribosome Entry Site from the Porcine Teschovirus-1 Talfan [PDF]
Journal of Virology, 2002 ABSTRACT The teschoviruses constitute a recently defined picornavirus genus. Most of the genome sequence of the porcine teschovirus-1 (PTV) Talfan and several other strains is known. We now demonstrate that initiation of protein synthesis occurs at nucleotide (nt) 412 on the PTV Talfan RNA and that nt 1 to 405 contains an internal ribosome ...
Kaku, Yoshihiro +3 more
openaire +3 more sources
Sapovirus translation requires an interaction between VPg and the cap binding protein eIF4E. [PDF]
, 2014 UNLABELLED: Sapoviruses of the Caliciviridae family of small RNA viruses are emerging pathogens that cause gastroenteritis in humans and animals. Molecular studies on human sapovirus have been hampered due to the lack of a cell culture system.
Chaudhry, Yasmin +4 more
core +2 more sources
Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.Seneca Valley virus (SVV) infection has recently disseminated across pig farms in Canada, America, and China. The SVV has been identified in humans, rodents, and houseflies. Although cross‐species transmission events may lead to limited subsequent transmission, sustained outbreaks have been observed in new mammalian hosts.
Ziliang Qin +14 more
wiley +1 more source
Identification of Novel Rosavirus Species That Infects Diverse Rodent Species and Causes Multisystemic Dissemination in Mouse Model [PDF]
, 2016 published_or_final_versio
Chan, BC +12 more
core +1 more source