Results 31 to 40 of about 263,174 (307)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Score Tests for Semiparametric Zero-inflated Poisson Models

International Journal of Statistics and Probability, 2012
Count data sets often produce many zeros. It is sometimes potentially questionable to use a linear predictor to model the effect of a continuous covariate of interest in zero-inflated count data. To relax the restriction, Li (2011) proposed a semiparametric zero-inflated Poisson (ZIP) regression model by using fixed-knot cubic $basis$ splines or $B ...
openaire   +2 more sources

Improvement in national test reading scores at Key Stage 1; grade inflation or better achievement? [PDF]

British Educational Research Journal, 2007
The aim of the UK National Literacy Strategy is to raise standards in literacy. Strong evidence for its success has, however, been lacking: most of the available data comes from performance on tests administered in schools or from Office for Standards in Education reports and is vulnerable to suggestions of bias.
Meadows, SAC, Herrick, DRM, Feiler, AC, the ALSPAC Study, Team   +3 more
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Use of Symptomatic Drug Treatment for Fatigue in Multiple Sclerosis and Patterns of Work Loss

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe the use of central stimulants and amantadine for fatigue in MS and evaluate a potential association with reduced work loss in people with MS. Methods We conducted a nationwide, matched, register‐based cohort study in Sweden (2006 to 2023) using national registers with prospective data collection.
Simon Englund, Johan Reutfors, Thomas Frisell, Fredrik Piehl   +3 more
wiley   +1 more source

The Source of Lake Wobegon

Nonpartisan Education Review, 2005
John J. Cannell's late 1980's “Lake Wobegon” reports suggested widespread deliberate educator manipulation of norm-referenced standardized test (NRT) administrations and results, resulting in artificial test score gains.
Richard P. Phelps
doaj  

Determinants of stunting in children under five years in dibate district of Ethiopia: A case-control study

Human Nutrition & Metabolism, 2022
Background: Chronic malnutrition is the consequence of long-term nutritional deficiency resulting in non-communicable disease and reduced productivity in later life. This situation primarily manifests through physical stunting, a term used to individuals
Dinaol Abdissa Fufa
doaj   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

The Source of Lake Wobegon (slide show)

Nonpartisan Education Review, 2007
John J. Cannell's late 1980's "Lake Wobegon" reports suggested widespread deliberate educator manipulation of norm-referenced standardized test (NRT) administrations and results, resulting in artificial test score gains.
Richard P. Phelps
doaj  

Note on the radical inflation in the estimates of error variance in measurement models

Frontiers in Education
This note discusses the radical technical inflation in error variance and the related standard error of test scores from both conceptual and empirical viewpoints. This technical inflation arises as a direct consequence of the technical underestimation of
Jari Metsämuuronen, Jari Metsämuuronen
doaj   +1 more source