Results 41 to 50 of about 8,095,618 (291)
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay +13 more
wiley +1 more source
Further Comment on "'Lake Woebegone,' Twenty Years Later"
no ...
Richard P. Phelps
doaj
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera +20 more
wiley +1 more source
“Lake Woebegone,” Twenty Years Later
Twenty years ago, John Cannell developed data on test scores that became known as the “Lake Woebegone effect.” This commentary describes that experience.
John Jacob Cannell, M.D.
doaj
Score Tests for Semiparametric Zero-inflated Poisson Models
Count data sets often produce many zeros. It is sometimes potentially questionable to use a linear predictor to model the effect of a continuous covariate of interest in zero-inflated count data. To relax the restriction, Li (2011) proposed a semiparametric zero-inflated Poisson (ZIP) regression model by using fixed-knot cubic $basis$ splines or $B ...
openaire +2 more sources
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch +5 more
wiley +1 more source
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno +19 more
wiley +1 more source
Comments on "'Lake Woebegone,' Twenty Years Later"
J. J. Cannell’s article on the so-called “Lake Woebegone” effect for K-12 educational testing systems is mostly an historical account of technical issues and policy considerations that led in part to development of new types of test instruments for K-12 ...
D. J. McRae, Ph.D.
doaj
White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram +3 more
wiley +1 more source

