Results 61 to 70 of about 21,990 (240)

Seminal Plasma Exosomal miRNA Profiling Reveals hsa‐miR‐7‐5p as a Key Regulator of Sperm Motility in Asthenozoospermia

Andrology, EarlyView.
ABSTRACT Background Asthenozoospermia is a significant contributing factor to male infertility. Accumulating evidence indicates that impaired sperm motility is closely linked to dysregulated microRNA expression during spermatogenesis. Seminal plasma exosomes are enriched with diverse microRNAs, which play pivotal roles in modulating sperm motility, the
Zhi‐Jian Zhu, Meng‐Li Cui, Wen‐Jing Yuan, Jia‐Ning Zhang, Shuo Zhang, Xi‐Qiao Yao, Ruo‐Qing Li, Jin‐Feng Li, En‐Zhong Li   +8 more
wiley   +1 more source

Epigenetics and testicular germ cell tumors

Gene, 2018
Abstract Malignant testicular germ cell tumors (TGCTs) are the most frequent testicular cancers in Caucasian males, developing at the most productive age of man. We are briefly reviewing TGCT-tumorigenesis with an emphasis on epigenetics. Epigenetic mechanisms such as DNA methylation and histone modifications together with RNA interference that all ...
Robert Buljubašić, Maja Buljubašić, Ana Katušić Bojanac, Monika Ulamec, Maja Vlahović, Davor Ježek, Floriana Bulić-Jakuš, Nino Sinčić   +7 more
openaire   +3 more sources

Histopathological analysis of testicular tumors

Journal of Pathology of Nepal, 2012
Background: Testicular cancers are rare in most countries. However, in many western countries its incidence has been increasing since the middle of the twentieth century. A definite geographic and racial distribution is seen in testicular tumors.
S Karki, RR Bhatta
doaj   +1 more source

Cryopreservation of Spermatozoa Prior and Post‐Orchiectomy in Patients With Testicular Germ Cell Cancer—Does the Timing Matter?

Andrology, EarlyView.
ABSTRACT Background Testicular germ cell cancer (TGCC) is the most frequent malignancy in young men of reproductive age. According to guidelines, semen cryopreservation should be performed prior to orchiectomy. Lack of time and local facilities as well as mental pressure are challenges in terms of fertility preservation before surgery.
Yuhe Tang, Gerald Pühse, Sabine Kliesch, Jann‐Frederik Cremers, Maria Schubert   +4 more
wiley   +1 more source

Chemotherapy-Induced Depletion of OCT4-Positive Cancer Stem Cells in a Mouse Model of Malignant Testicular Cancer

Cell Reports, 2017
Summary: Testicular germ cell tumors (TGCTs) are among the most responsive solid cancers to conventional chemotherapy. To elucidate the underlying mechanisms, we developed a mouse TGCT model featuring germ cell-specific Kras activation and Pten ...
Timothy M. Pierpont, Amy M. Lyndaker, Claire M. Anderson, Qiming Jin, Elizabeth S. Moore, Jamie L. Roden, Alicia Braxton, Lina Bagepalli, Nandita Kataria, Hilary Zhaoxu Hu, Jason Garness, Matthew S. Cook, Blanche Capel, Donald H. Schlafer, Teresa Southard, Robert S. Weiss   +15 more
doaj   +1 more source

Inhibition of HMGA2 Leads to Reduced Cell Proliferation and Increased Apoptosis in Human Embryonal Carcinoma Cell Lines

Andrology, EarlyView.
ABSTRACT Background The most prevalent solid tumors in young men are testicular germ cell tumors (TGCTs), and embryonal carcinoma is the most common subtype among non‐seminomatous germ cell tumors (NSGCTs). Despite the excellent cure rates of cisplatin‐based chemotherapy, resistance develops in 15%–30% of patients with metastatic cancer, which results ...
Marco De Martino, Matteo Lampitto, Alfredo Fusco, Marco Barchi, Francesco Esposito, Paolo Chieffi   +5 more
wiley   +1 more source

Supplementary Table 1 from Circulating Tumor Cells in Patients with Testicular Germ Cell Tumors [PDF]

, 2023
Paulina Nastały, Christian Ruf, Pascal Becker, Natalia Bednarz‐Knoll, Małgorzata Stoupiec, Refik Kavsur, Hendrik Isbarn, Cord Matthies, Wolfgang Wagner, Dirk Höppner, Margit Fisch, Carsten Bokemeyer, Sascha Ahyai, Friedemann Honecker, Sabine Riethdorf, Klaus Pantel   +15 more
openalex   +1 more source

Guideline of guidelines: management of small testicular masses

BJU International, EarlyView.
Objective To compare and summarise the most up to date international guidelines and major recommendations for the management of small testicular masses (STMs). Methods A systematic search was conducted in PubMed, EMBASE, Scopus, Google Scholar, and the Cochrane Library up to 1 November 2024.
Marco Tozzi, Giuseppe Fallara, Matteo Ferro, Francesco Chierigo, Roberto Bianchi, Hussain M. Alnajjar, Karl H. Pang, Asif Muneer   +7 more
wiley   +1 more source

Testicular choriocarcinoma with pelvic and pulmonary metastases: a case report

Frontiers in Oncology
Testicular tumors represent a common form of solid tumor in young men, with choriocarcinoma of the testis being a rare, non-granulomatous germ cell tumor. It accounts for less than 0.3% of all testicular germ cell tumors.
Xin Bai, Xiao H. Liu, Hai W. Liang, Yi S. Li, Biao F. Shan, Jian M. Tang   +5 more
doaj   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source