A multiplex tissue resource for high‐resolution spatial protein profiling in the Human Protein Atlas
Abstract Spatially resolved protein expression is essential for understanding tissue organization, cellular specialization, and protein function. The open‐access Human Protein Atlas database (www.proteinatlas.org) has generated an extensive antibody‐based tissue resource for a majority of the human protein‐coding genes using conventional ...
Borbala Katona +9 more
wiley +1 more source
Cancer heterogeneity explored through immune cell deconvolution of the tumor microenvironment
Abstract Cancer is a highly heterogeneous disease, characterized by significant variability across multiple dimensions. This diversity has been extensively studied from various perspectives. In this study, we aim to examine cancer heterogeneity through the lens of immune cell composition within the tumor microenvironment.
Limin Jiang +4 more
wiley +1 more source
Sertoli cell tumor in familial adenomatous polyposis: a case report. [PDF]
Kakarala C +4 more
europepmc +1 more source
Metastatic Leiomyosarcoma Involving Bone and Kidney in an Adult Budgerigar (Melopsittacus undulatus)
A 2‐year‐old male budgerigar presents with swelling of the medial left leg. Soft tissue neoplasia is suspected after empirical treatment fails. Histopathology and immunohistochemistry (α‐SMA and desmin positivity, vimentin negativity) confirm leiomyosarcoma, with metastasis to bone and kidneys. This case documents uncommon metastatic spread in an avian
Hemad Shafiei +4 more
wiley +1 more source
Metastatic Testicular Germ Cell Tumor in a Patient With Neurofibromatosis Type 1: Treatment With Trametinib Based on <i>NF1</i> Gene Mutation. [PDF]
Goto K +9 more
europepmc +1 more source
Can Hormonal Therapy Improve the Outcomes of mTESE in Patients With Non‐Obstructive Azoospermia?
ABSTRACT Background Non‐obstructive azoospermia (NOA) represents the most severe form of male infertility. Hypogonadism is common in NOA patients, and normal testosterone (T) levels are considered essential for spermatogenesis. Fertility‐preserving hormonal therapy (FpHT) has been proposed to optimize hormonal milieu and improve sperm retrieval rates ...
Mattia Anfosso +5 more
wiley +1 more source
Cancer Prevalence Among Large Cohort of Individuals With Down Syndrome: Implications for Screening Guidelines. [PDF]
Fitzpatrick V +6 more
europepmc +1 more source
Background Testicular germ cell tumours (TGCTs) are the most common malignancy in men aged 15–35 years. Management options for men with TGCTs include surgery, radiation and/or chemotherapy, depending on stage. Given TGCTs’ excellent survival, most patients live long enough to experience delayed treatment toxicities, warranting careful consideration of ...
Ahmad Mousa +5 more
wiley +1 more source
Comparative Molecular and Genetic Landscape of Gonadal Germ Cell Tumors: Insights from Testicular and Ovarian Neoplasms. [PDF]
Parteni DE +9 more
europepmc +1 more source

