Results 101 to 110 of about 10,163,401 (273)

Testing the Guide [PDF]

open access: yes, 2015
This past week, I implemented the user test that I had designed for the new History research guide. I enlisted five participants from the history alias, ensuring that I had one participant from each class year so that I could test the spectrum of ...
Fowle, Megan E.
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Fatigue testing device [PDF]

open access: yes, 1973
Anti-buckling assembly prevents buckling of sheet metal fatigue specimen when axial compressive load is applied. It provides for cyclic heating and cooling of specimen during testing. Assembly permits tests at two locations on specimen.
Eichenbrenner, F. E., Imig, L. A.
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Testing Nonlinearity: Decision Rules for Selecting between Logistic and Exponential STAR Models. [PDF]

open access: yes
A new LM specification procedure to choose between Logistic and Exponential Smooth Transition Autoregressive (STAR) models is introduced. The new decision rule has better properties than those previously available in the literature when the model is ...
Escribano, Álvaro, Jordá, Oscar
core  

Requirements and Test Stand Development for ERS Pantographs

open access: yesWorld Electric Vehicle Journal
Electric road systems (ERSs) are a promising solution for electrifying heavy-duty freight transport by providing traction and charging power from the power lines installed along the road.
Alexander Prinz   +4 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Determination of the Most Damaging Operational Loading Modes of Load-Bearing Structures of the Dump Truck Body by Fatigue Criterion

open access: yesМеханика машин, механизмов и материалов
A procedure is developed for the calculation and experimental assessment of the operatonal modes damaging effect on the load-bearing structure of a dump truck body. The procedure makes it possible to determine the most dangerous zones of the load-bearing
Aliaksei V. Shmialiou   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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