Results 51 to 60 of about 1,799,144 (293)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Scientific ReportsElectromagnetic methods for non-destructive evaluation (NDE) are presented, with which sheet metal components can be identified and their material properties can be characterized.
Bernd Wolter +6 more
doaj +1 more source
Testing device subjects elastic materials to biaxial deformations [PDF]
, 1965 Testing device stretches elastic materials biaxially over large deformation ranges and varies strain ratios in two perpendicular directions. The device is used in conjunction with a tensile testing machine, which holds the specimen and permits control ...
Becker, G. W.
core +1 more source
On the testability of SDL specifications [PDF]
, 2004 The problem of testing from an SDL specification is often complicated by the presence of infeasible paths. This paper introduces an approach for transforming a class of SDL specification in order to eliminate or reduce the infeasible path problem.
H. Ural +9 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Reliability Assessment of a Packaging Automatic Machine by Accelerated Life Testing Approach [PDF]
, 2017 Industrial competitiveness in innovation, the time of the market introduction of new machines and the level of reliability requested implies that the strategies for the development of products must be more and more efficient.
Casto, Andrea +4 more
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Metals, 2022 To make powder bed fusion (PBF) via laser beam (-LB) for metals (/M) available for highly regulated components such as pressure equipment according to the Pressure Equipment Directive, system-specific qualification methods need to be established to deal ...
Hoang Minh Vu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
EPJ Web of Conferences, 2015 CTOAC of typical X70, X80 and X90 pipeline steels plates were evaluated by using energy based regression method upon their single specimen. Clear difference in the material resistance to ductile cracking could be distinguished by the values of CTOAC and ...
Fang Jian, Zhang Jian-wei, Huang Xing
doaj +1 more source