Results 61 to 70 of about 1,799,144 (293)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Part Form Errors Predicted from Machine Tool Performance Measurements [PDF]
, 1997 Machine tool performance testing, as defined by IS0 230 and ANSI B5.54 has been successfully used to maintain and improve the accuracy and repeatability of production-level machine tools.
Farabaugh, F. +3 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
, 1980 Requirements for the space fabrication of large space structures are considered with emphasis on the design, development, manufacture, and testing of a machine which automatically produces a basic building block aluminum beam.
Muench, W. K.
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Process and machine system development for the forming of miniature/micro sheet metal products [PDF]
, 2007 This paper reports on the current development of the process for the forming of thin sheet-metal micro-parts (t < 50µm) and the corresponding machine system which is part of the research and technological development of an EU funded integrated project ...
Brockett, A. +7 more
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Towards using web-crawled data for domain adaptation in statistical machine translation [PDF]
, 2011 This paper reports on the ongoing work focused on domain adaptation of statistical machine translation using domain-specific data obtained by domain-focused web crawling.
Giagkou, Maria +5 more
core
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Research on Adhesion Pull-Off Behavior of Rigid Flat Punch and Viscoelastic Substrate
MathematicsInterfacial adhesion is one of the key factors affecting the reliability of micro–nano systems. The adhesion contact mechanism is still unclear as the time-dependent viscoelasticity of soft materials.
Tao Zhang, Yunqi Zhang, Kai Jiang
doaj +1 more source