Results 71 to 80 of about 325,350 (309)

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Dysregulation of angiogenesis-specific signalling in adult testis results in xenograft degeneration

Scientific Reports, 2017
Ectopic xenografting of testis is a feasible option for preservation of male fertility and angiogenesis plays a pivotal role in xenograft survival and functionality.
Lalitha Devi, Lavanya Pothana, Sandeep Goel   +2 more
doaj   +1 more source

Differential expression of estrogen receptor α and progesterone receptor in the normal and cryptorchid testis of a dog

Laboratory Animal Research, 2016
Descending of the testes is an important process for spermatogenesis and cryptorchidism is one of the most relevant genital defects in dogs. In a previous study, we observed abnormal morphology and proliferation of Sertoli cells in a cryptorchid testis ...
Hyo Young Jung, Dae Young Yoo, Young Kwang Jo, Geon A. Kim, Jin Young Chung, Jung Hoon Choi, Goo Jang, In Koo Hwang   +7 more
doaj   +1 more source

Action of the Metalloproteinases in Gonadal Remodeling during Sex Reversal in the Sequential Hermaphroditism of the Teleostei Fish Synbranchus marmoratus (Synbranchiformes: Synbranchidae) [PDF]

, 2018
Teleostei present great plasticity regarding sex change. During sex reversal, the whole gonadincluding the germinal epithelium undergoes significant changes, remodeling, and neoformation.However, there is no information on the changes that occur within ...
Antoneli, Fernanda, Lo Nostro, Fabiana Laura, Mazzoni, Talita Sarah, Quagio-Grassiotto, Irani   +3 more
core   +2 more sources

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

Contribution of recent transgenic models and transcriptional profiling studies to our understanding of the mechanisms by which androgens control spermatogenesis [PDF]

, 2008
Publisher ...
Claessens, Frank, De Gendt, Karel, Denolet, Evi, Saunders, Philippa T K, Sharpe, Richard, Swinnen, Johannes V, Verhoeven, Guido, Willems, Ariane   +7 more
core   +1 more source

Sertoli Cell‐Derived Extracellular Vesicles Orchestrate Cadmium‐Induced Testicular Inflammation and Fibrosis

Advanced Science, EarlyView.
Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
Jianfeng Ma, Mailin Gan, Shuang Liang, Siyu Chen, Ziling Hao, Yiting Yang, Jiawei Lu, Qihang Wu, Yuqian Shi, Lijun Sun, Jiaxin Li, Saihao Wang, Yan Wang, Xiaofeng Zhou, Lei Chen, Ye Zhao, Li Zhu, Linyuan Shen   +17 more
wiley   +1 more source

Myotube migration to cover and shape the testis of Drosophila depends on Heartless, Cadherin/Catenin, and myosin II

Biology Open, 2017
During Drosophila metamorphosis, nascent testis myotubes migrate from the prospective seminal vesicle of the genital disc onto pupal testes and then further to cover the testes with multinucleated smooth-like muscles.
Silke Rothenbusch-Fender, Katharina Fritzen, Maik C. Bischoff, Detlev Buttgereit, Susanne F. Oenel, Renate Renkawitz-Pohl   +5 more
doaj   +1 more source

SEASONAL INCIDENCE OF CAPTURE AND REPRODUCTION OF FIVE FOSSORIAL SNAKE SPECIES IN WEST VIRGINIA [PDF]

, 2017
Museum specimens of five species of fossorial snakes collected in West Virginia during 1930–2000 were examined to determine monthly incidence of capture, adult body sizes, reproductive cycle, and clutch characteristics.
Herrick, Kelli-Marie, Meshaka, Walter E., Pauley, Thomas K., Wright, Danielle F.   +3 more
core   +2 more sources

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source