Results 1 to 10 of about 7,621 (135)

Transplantation of spermatogonial stem cells in stallions. [PDF]

J Anim Sci Technol
Spermatogonial stem cells originate from gonocytes and undergo self-renewal and differentiation to generate mature spermatozoa via spermatogenesis in the seminiferous tubules of the testis in male mammals. Owing to the unique capacity of these cells, the spermatogonial stem cell transplantation technique, which enables the restoration of male fertility
Jung H, Yoon M.
europepmc   +4 more sources

Spermatogonial stem cells† [PDF]

Biology of Reproduction, 2018
AbstractSpermatogonial stem cells (SSCs) are the most primitive spermatogonia in the testis and have an essential role to maintain highly productive spermatogenesis by self-renewal and continuous generation of daughter spermatogonia that differentiate into spermatozoa, transmitting genetic information to the next generation.
Hiroshi Kubota, Ralph L Brinster
openaire   +2 more sources

Spermatogonial stem cells An update on spermatogonial stem cell banking and transplantation

Biomedicine & Pharmacotherapy, 2008
Introduction: Approximately one in 600 children will develop cancer before the age of 15 years. Thanks to recent advances in chemo- and radiotherapy, cure rates of childhood cancers are as high as 80%. It has been estimated that by 2010, one in 250 young adults may be long-term survivors of childhood cancer.
Goossens, Ellen, Van Saen, Dorien, Geens, Mieke, Ning, Liang, Tournaye, Herman   +4 more
openaire   +4 more sources

Spermatogonial Stem Cell Niche and Spermatogonial Stem Cell Transplantation in Zebrafish

PLoS ONE, 2010
Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis, and reside within a specific microenvironment in the testes called "niche" which regulates stem cell properties, such as, self-renewal, pluripotency, quiescence and their ability to differentiate.Here, we introduce zebrafish as a new model for the study of SSCs in vertebrates ...
Nóbrega, Rafael Henrique, Greebe, Caaj Douwe, van de Kant, Henk, Bogerd, Jan, de França, Luiz Renato, Schulz, Rüdiger W.   +5 more
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Defining the spermatogonial stem cell

Developmental Biology, 2004
Through the use of donor cells from transgenic rats expressing GFP exclusively in the germline, we have defined culture conditions where male germ cells lose (on STO cells) or maintain (on MSC-1 cells) stem cell activity. A cadre of germ cell transcripts strikingly decrease in relative abundance as a function of testis age or culture time on STO cells,
Kent Hamra, F., Schultz, Nikolaus, Chapman, Karen M., Grellhesl, Dana M., Cronkhite, Jennifer T., Hammer, Robert E., Garbers, David L.   +6 more
openaire   +2 more sources

Plasticity of spermatogonial stem cells

Asian Journal of Andrology, 2015
There have been significant breakthroughs over the past decade in the development and use of pluripotent stem cells as a potential source of cells for applications in regenerative medicine. It is likely that this methodology will begin to play an important role in human clinical medicine in the years to come. This review describes the plasticity of one
Paul S Cooke, Liz Simon, Manjunatha K Nanjappa, Theresa I Medrano, Suzanne E Berry   +4 more
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Spermatogonial stem cells: Progress and prospects

Asian Journal of Andrology, 2015
Twenty years ago, the transplantation of spermatogonial stem cells (SSCs) from a mouse to other recipient mice was shown to be feasible, which clearly demonstrated the functional identity of SSCs. Since then, several important new findings and other technical developments have followed, which included a new hypothesis on their cell kinetics and ...
Mitsuru Komeya, Takehiko Ogawa
openaire   +3 more sources

Regulation of the Spermatogonial Stem Cell Niche [PDF]

Reproduction in Domestic Animals, 2008
ContentsSpermatogonial stem cells (SSCs) reside within specialized microenvironments called ‘niches’, which are essential for their maintenance and self‐renewal. In the mammalian testis, the main components of the niche include the Sertoli cell, the growth factors that this nursing cell produces, the basement membrane, and stimuli from the vascular ...
N, Kostereva, M-C, Hofmann
openaire   +2 more sources

Culture of mouse spermatogonial stem cells [PDF]

Tissue and Cell, 1998
Spermatogenesis occurs within the seminiferous tubules of mammals by a complex process that is highly organized, extremely efficient and very productive. At the foundation of this process is the spermatogonial stem cell that is capable of both self-renewal and production of progeny cells, which undergo differentiation over a period of weeks to months ...
M, Nagano, M R, Avarbock, E B, Leonida, C J, Brinster, R L, Brinster   +4 more
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Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source