Results 31 to 40 of about 7,621 (135)

From “Passive Supplementation” to “Active Repair”: Melatonin Reshapes the Treatment Paradigm for Late‐Onset Hypogonadism by Targeting Leydig Cell Senescence

Aging Cell, Volume 25, Issue 5, May 2026.
Melatonin restores testosterone production in aging Leydig cells by targeting key pathological drivers, particularly oxidative stress and mitochondrial dysfunction. This approach offers a fundamental strategy to reshape the Late‐onset hypogonadism treatment paradigm.
Hui Wu, Gang Ning, Mintao Jian, Ajian Peng, Haoyu Wang, Bonan Li, Xing Zhou   +6 more
wiley   +1 more source

Proliferation and differentiation of spermatogonial stem cells [PDF]

Reproduction, 2001
Abstract Spermatogonial stem cells (A(s) spermatogonia) are single cells that either renew themselves or produce A(pr) (paired) spermatogonia predestined to differentiate. In turn, the A(pr) divide into chains of A(al) (aligned) spermatogonia that also divide.
openaire   +2 more sources

Mechanical Force Promotes Mitochondrial Transfer From Macrophages to BMSCs to Enhance Bone Formation

Cell Proliferation, Volume 59, Issue 5, May 2026.
Mechanical tension activates Drp1‐mediated mitochondrial fission in macrophages, facilitating the release of Mito‐EVs that are subsequently transferred to BMSCs. Additionally, the CD200R‐CD200 interaction enhances the uptake of these mechanically stimulated macrophage‐derived Mito‐EVs by BMSCs, ultimately promoting osteogenic differentiation.
Yingyi Li, Ziwei Yan, Yueming Dai, Hanjia Cai, Yue Chen, Yuyi Chen, Ruofan Jin, Wen Sun, Hua Wang   +8 more
wiley   +1 more source

Spermatogonial stem cells and in vitro spermatogenesis [PDF]

Reproductive Medicine and Biology, 2011
AbstractSpermatogonial stem cells (SSCs) provide the basis for the life‐long production of enormous numbers of sperm. The nature of these mysterious cells is being clarified. Although they were regarded to be mostly dormant, dividing rarely and remaining static in a niche, their rather dynamic behavior in the seminiferous tubules has been disclosed ...
openaire   +2 more sources

The nature and dynamics of spermatogonial stem cells [PDF]

Development, 2017
Spermatogonial stem cells (SSCs) are crucial for maintaining spermatogenesis throughout life, and understanding how these cells function has important implications for understanding male infertility. Recently, various populations of cells harbouring stem cell-like properties have been identified in rodent seminiferous tubules, but deciphering how these
openaire   +3 more sources

Spermatogonial Stem Cells

, 2004
Schatten, Heide, Nayernia, Karim, Li, Manyu, Engel, Wolfgang   +3 more
openaire   +6 more sources

Spermatogonial stem cells of the testis.

Proceedings of the National Academy of Sciences, 1994
Recent studies by Brinster and colleagues reported in this issue of the Proceedings (1, 2) have shown that the injection of spermatogonial stem cells into the testes of sterile recipient mice gives rise to functional sperm in the recipients. These results provide a new technique for the investigation of the physiology of the spermatogonial stem cells ...
openaire   +3 more sources

Celiotomy to collect spermatogonial stem cells in <i>Brycon orbignyanus</i> for species preservation. [PDF]

Anim Reprod
da Silva LG, Torres-Lozano KG, Rodrígues RB, de Freitas TR, Povh JA, Spica LN, Teixeira NDS, Selle DC, Benato JL, Dos Santos RS, Nicoleti ET, Dantas RV, Streit DP.   +12 more
europepmc   +1 more source

Impact of the hypoxic microenvironment on spermatogonial stem cells in culture. [PDF]

Front Cell Dev Biol, 2023
Gille AS, Givelet M, Pehlic D, Lapoujade C, Lassalle B, Barroca V, Bemelmans AP, Borderie D, Moison D, Livera G, Gauthier LR, Boussin FD, Thiounn N, Allemand I, Peyssonnaux C, Wolf JP, Barraud-Lange V, Riou L, Fouchet P.   +18 more
europepmc   +1 more source

YBX1 downregulation links to impaired spermatogonial stem cells function potentially through inhibiting miRNAs production. [PDF]

iScience
Zhu Y, Mao G, Geng X, Dou Q, Xiang Y, Ma L, Wei L, Tan L.   +7 more
europepmc   +1 more source