Results 31 to 40 of about 4,947,310 (176)

Epigenetic profiles signify cell fate plasticity in unipotent spermatogonial stem and progenitor cells

Nature Communications, 2016
Spermatogonial stem cells (SSCs) spontaneously convert to multipotent adult spermatogonial-derived stem cells (MASCs). Here, the authors reveal the dynamics of bivalent histone H3-lysine4 and -lysine27 methylation signatures at somatic gene promoters in ...
Ying Liu, Eugenia G. Giannopoulou, Duancheng Wen, Ilaria Falciatori, Olivier Elemento, C. David Allis, Shahin Rafii, Marco Seandel   +7 more
doaj   +1 more source

The effect of insulin-like growth factor-1 on the proliferation of goat spermatogonial stem cells (SSCs) in vitro [PDF]

Fiyz̤, 2023
Background: This study aimed to the effect of insulin-like growth factor-1 on the proliferation of goat spermatogonial stem cells (SSCs) in vitro. Materials and Methods: The testicles of immature goats were obtained from slaughterhouse.
Milad Torabi, Peyman Rahimi-Feyli , Aliasghar Moghaddam   +2 more
doaj   +1 more source

CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes [PDF]

, 2014
Standard culture of human induced pluripotent stem cells (hiPSCs) requires basic Fibroblast Growth Factor (bFGF) to maintain the pluripotent state, whereas hiPSC more closely resemble epiblast stem cells than true naïve state ES which requires LIF to ...
Tang, D, Suzuki, H., Forrest, Alistair R. R., Hasegawa, Y., Suzuki, H, Ovchinnikov, Dmitry A., Hitchens, Kelly J., Takahashi, N., Forrest, A.R.R., Kenna, Tony, Suzuki, Harukazu, Tang, D., Joshi, Anagha, Hayashizaki, Y., Wolvetang, Ernst, Tang, Dave, Suzuki, H., Forrest, Alistair R R, FANTOM Consortium, the FANTOM consortium, Vijayan, Dipti, Wells, Christine A., Hasegawa, Y, Hayashizaki, Yoshihide, Forrest, ARR, Takahashi, Naoko, Briggs, James, Hasegawa, Yuki, Blumenthal, Antje, Tang, D., Hayashizaki, Y, ?, ?, Sajantila, Antti, Hasegawa, Y., Takahashi, N, Takahashi, N., Forrest, A. R., Beckhouse, Anthony G., FANTOM Consortium,, Hayashizaki, Y.   +39 more
core   +1 more source

Separating mouse malignant cell line (EL4) from neonate spermatogonial stem cells utilizing microfluidic device in vitro

Stem Cell Research & Therapy, 2020
Background Some children who have survived cancer will be azoospermic in the future. Performing isolation and purification procedures for spermatogonial stem cells (SSC) is very critical.
Behnaz Ashtari, Azar Shams, Narges Esmaeilzadeh, Sara Tanbakooei, Morteza Koruji, Mojtaba Johari Moghadam, Javad Mohajer Ansari, Adel Johari Moghadam, Ronak Shabani   +8 more
doaj   +1 more source

Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells. [PDF]

PLoS ONE, 2010
Vaccinia-related kinase 1 (VRK1) is a crucial protein kinase for mitotic regulation. VRK1 is known to play a role in germ cell development, and its deficiency results in sterility.
Yoon Ha Choi, Choon-Ho Park, Wanil Kim, Hua Ling, Aram Kang, Matthew Wook Chang, Sun-Kyoung Im, Hyun-Woo Jeong, Young-Yun Kong, Kyong-Tai Kim   +9 more
doaj   +1 more source

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

Genes involved in spermatogonial stem cell self-renewal and differentiation [PDF]

, 2008
Spermatozoa are produced by the process of spermatogenesis. At the base of this process is a pool of spermatogonial stem cells that generate new stem cells as well as committed spermatogonia that will eventually differentiate in spermatozoa.
Genes/proteins responsible for the regulation of proliferation and differentiation of spermatogonial stem cells, van Bragt, M.P.A., Dep Biologie   +2 more
core   +1 more source

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

Advanced Science, EarlyView.
DUET‐seq is an open‐source droplet platform that jointly profiles chromatin accessibility and gene expression from the same nucleus. Dissolvable dual‐linker hydrogel beads and a one‐step intra‐droplet RT‐PCR co‐index both modalities in under 12 h at roughly $0.04 per cell.
Dong Cheng, Zijun Meng, Lan Wei, Pingjing Yang, Fanfan Zhang, Zhiyi Luo, Ting Lai, Chunli Li, Mengyao Zhao, Mengqin Xu, Jiaqi Wang, Linjun Li, Huarong Chen, Jin Li, Ailong Huang, Youquan Bu, Liuyang Zhao   +16 more
wiley   +1 more source

The Effect of Silk Nanofibrous Scaffold and Co-Culture with Sertoli Cells on Spermatogonial Stem Cell Proliferation

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2021
BACKGROUND AND OBJECTIVE: In vitro proliferation and maintenance of spermatogonial stem cells is one of the treatment options for infertile men. Creating a suitable microenvironment similar to the natural conditions of reproduction of these cells leads ...
Z Narimanpour, M Nazm Bojnordi, H Ghasemi   +2 more
doaj  

Possible use of spermatogonial stem cells in the treatment of male infertility

Вестник трансплантологии и искусственных органов, 2020
Spermatogonial stem cells, which are already present at birth in the testicles, are the progenitors of male gametes. These cells cannot produce mature sperm before puberty due to their dependence on hormonal stimuli.
N. N. Skaletsky, G. N. Skaletskaya, V. I. Sevastianov   +2 more
doaj   +1 more source