Results 91 to 100 of about 169,506 (312)

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

No effects of androgen receptor gene CAG and GGC repeat polymorphisms on digit ratio (2D:4D): Meta-analysis [PDF]

arXiv, 2013
Objectives: A series of meta-analyses assessed whether differentially efficacious variants (CAG and GGC repeat-length polymorphisms) of the human androgen receptor gene are associated with digit ratio (2D:4D), a widely investigated putative pointer to prenatal androgen action.
arxiv  

Testosterone and the brain [PDF]

The Aging Male, 2006
Gender differences in spatial recognition, and age-related declines in cognition and mood, point towards testosterone as an important modulator of cerebral functions. Testosterone appears to activate a distributed cortical network, the ventral processing stream, during spatial cognition tasks, and addition of testosterone improves spatial cognition in ...
openaire   +2 more sources

Optimization of Steroid Photochemistry and Its Application in the Synthesis of 5,6‐Dihydro‐Ophiopogonol A

Chemistry – A European Journal, EarlyView.
Steroid photoreactivity was a major topic in the last century. This study revisits it by exploring the photochemistry of Δ1‐keto‐steroids, offering an efficient method to modify the classic steroid 6/6/6/5 ring system. This approach enables the transformation of accessible steroids into rare ones, demonstrated by synthesizing 5,6‐dihydro‐ophiopogonol A
Chiara Maioli, Gianluigi Lauro, Anna Sategna, Diego Caprioglio, Hawraz Ibrahim M. Amin, Maurizio D'Auria, Daniela Imperio, Giuseppe Bifulco, Alberto Minassi   +8 more
wiley   +1 more source

Gene Therapy Using Recombinant AAV Type 8 Vector Encoding TNAP‐D10 Improves the Skeletal Phenotypes in Murine Models of Osteomalacia

JBMR Plus, Volume 7, Issue 1, January 2023., 2023
ABSTRACT Hypophosphatasia (HPP), caused by loss‐of‐function mutations in the ALPL gene encoding tissue‐nonspecific alkaline phosphatase (TNAP), is characterized by skeletal and dental hypomineralization that can vary in severity from life‐threatening to milder manifestations only in adulthood.
Flavia Amadeu de Oliveira, Fatma F. Mohamed, Yuka Kinoshita, Sonoko Narisawa, Colin Farquharson, Koichi Miyake, Brian L Foster, Jose Luis Millan   +7 more
wiley   +1 more source

Mouse testicular macrophages can independently produce testosterone and are regulated by Cebpb

Biological Research
Background Testicular macrophages (TM) have long been recognized for their role in immune response within the testicular environment. However, their involvement in steroid hormone synthesis, particularly testosterone, has not been fully elucidated.
Nengliang Duan, Yuanshuai Ran, Huapei Wang, Ya Luo, Zhixiang Gao, Xingyu Lu, Fengmei Cui, Qiu Chen, Boxin Xue, Xiaolong Liu   +9 more
doaj   +1 more source

Highly‐selective Electrochemical Decarboxylative Late‐Stage Functionalization of Amino Acids

Chemistry – A European Journal, Accepted Article.
A unified electrochemical decarboxylative strategy for the site‐selective construction of carbon‐heteroatom bonds is disclosed herein. The metal‐ and catalyst‐free decarboxylation provides access to functionalization of C‐ and N‐terminus from simple amino acid feedstock.
Adrija Ghosh, Vishal Kumar Parida, Tristan von Münchow, Lutz Ackermann, Debasis Banerjee   +4 more
wiley   +1 more source

Sexing Bones: Improving Transparency of Sex Reporting to Address Bias Within Preclinical Studies

Journal of Bone and Mineral Research, Volume 38, Issue 1, Page 5-13, January 2023., 2023
ABSTRACT Despite knowledge that sexually dimorphic mechanisms regulate bone homeostasis, sex often remains unreported and unconsidered in preclinical experimental design. Failure to report sex could lead to inappropriate generalizations of research findings and less effective translation into clinical practice.
Aikta Sharma, Lysanne V Michels, Andrew A Pitsillides, Julie Greeves, Lillian I Plotkin, Valentina Cardo, Natalie A Sims, Claire E Clarkin   +7 more
wiley   +1 more source

Testosterone and androstanediol glucuronide among men in NHANES III

BMC Public Health, 2018
Background Most of the androgen replacement therapies were based on serum testosterone and without measurements of total androgen activities. Whether those with low testosterone also have low levels of androgen activity is largely unknown.
Chuan Wei Duan, Lin Xu
doaj   +1 more source

Osteocyte Estrogen Receptor β (Ot‐ERβ) Regulates Bone Turnover and Skeletal Adaptive Response to Mechanical Loading Differently in Male and Female Growing and Adult Mice

Journal of Bone and Mineral Research, Volume 38, Issue 1, Page 186-197, January 2023., 2023
ABSTRACT Age‐related bone loss is a failure of balanced bone turnover and diminished skeletal mechanoadaptation. Estrogen receptors, ERα and ERβ, play critical roles in osteoprotective regulation activated by estrogen and mechanical signals. Previous studies mainly focused on ERα and showed that osteocyte‐ERα (Ot‐ERα) regulated trabecular, but not ...
Xiaoyu Xu, Haisheng Yang, Whitney A. Bullock, Maxim A. Gallant, Claes Ohlsson, Teresita M. Bellido, Russell P. Main   +6 more
wiley   +1 more source