Results 101 to 110 of about 502,065 (385)

Aspects of the behavioral and endocrine ontogeny of six moustached tamarins, Saguinus mystax (Callitrichinae) [PDF]

, 2004
Deutsche Forschungsgemeinschaft (HE 1870/10-1 ...
Abbott, Baker, Bouissou, Cleveland, Dixson, Eckhard W. Heymann, French, Ginther, Heymann, Huck, Huck, Lö, Maren Huck, Martin, Michael Heistermann, Oversluijs Vá, Pereira, Petra Löttker, Plant, Ross, Soini, Ventura, Wickings   +22 more
core   +2 more sources

Potent Antisickling Furaldehyde Analogs for Acute Sickle Cell Therapy: Enhanced Efficacy and Intravenous Formulation Potential

ChemMedChem, EarlyView.
This study reports novel 5‐HMF analogs with potent antisickling activities. Lead compound MMA509 enhances hemoglobin oxygen affinity and prevents erythrocyte sickling. Crystal structure of hemoglobin‐MMA509 complex explains MMA509 mechanism of action. An IV formulation is successfully developed, positioning MMA509 as a promising fast‐acting treatment ...
Abdelsattar M. Omar, Moustafa E. El‐Araby, Tarek A. Ahmed, Akua K. Donkor, Albert Opare, Mohini S. Ghatge, Anfal S. Aljahdali, Rana T. Alhashimi, Trevohn N. Robinson, Benita Balogun, Mariana Macias, Salma Roland, Yan Zhang, Faik N. Musayev, Osheiza Abdulmalik, Martin K. Safo   +15 more
wiley   +1 more source

Associations Between Low Serum Testosterone and All-Cause Mortality and Infection-Related Hospitalization in Male Hemodialysis Patients: A Prospective Cohort Study

Kidney International Reports, 2017
Infectious diseases are the second highest cause of death in patients on dialysis. In addition, testosterone deficiency or hypogonadism is prevalent in dialysis patients.
Akio Nakashima, Ichiro Ohkido, Keitaro Yokoyama, Aki Mafune, Mitsuyoshi Urashima, Takashi Yokoo   +5 more
doaj   +1 more source

Elevated fetal steroidogenic activity in autism [PDF]

, 2014
Autism affects males more than females, giving rise to the idea that the influence of steroid hormones on early fetal brain development may be one important early biological risk factor.
Abdallah, M W, Auyeung, B, Baron-Cohen, S, Chakrabarti, B, Cohen, A S, Hougaard, D M, Lombardo, M V, Melgaard, L, Nørgaard-Pedersen, B, Ruta, L   +9 more
core   +1 more source

Testosterone and the brain [PDF]

The Aging Male, 2006
Gender differences in spatial recognition, and age-related declines in cognition and mood, point towards testosterone as an important modulator of cerebral functions. Testosterone appears to activate a distributed cortical network, the ventral processing stream, during spatial cognition tasks, and addition of testosterone improves spatial cognition in ...
openaire   +2 more sources

Pharmacokinetics, Tolerability, and Biomarker Profile of the Neurokinin 3 Receptor Antagonist Fezolinetant in Healthy Japanese Individuals: A 2‐Part, Randomized, Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This 2‐part, randomized, placebo‐controlled, double‐blind, Phase 1 study analyzed the pharmacokinetics, safety, and biomarker profile of fezolinetant in healthy Japanese individuals. Part 1: male participants received single doses of placebo or fezolinetant 15 or 60 mg.
Akira Koibuchi, Megumi Iwai, Kanji Komatsu, Kentaro Kuroishi, Mai Shibata, Masako Saito, Jace Nielsen, Jiayin Huang, Shunji Matsuki   +8 more
wiley   +1 more source

Testosterone and Cholesterol Vasodilation of Rat Aorta Involves L-Type Calcium Channel Inhibition

Advances in Pharmacological Sciences, 2010
Testosterone has rapid nongenomic vasodilator effects which could be involved in protective cardiovascular actions. Several authors suggested specific mechanisms to explain this effect, but this matter was not clarified yet.
E. Álvarez, E. Cairrão, M. Morgado, C. Morais, I. Verde   +4 more
doaj   +1 more source

In‐Depth Assessment of Cytologic Features in 106 Cervical Papanicolaou Tests of Transgender Male Patients on Testosterone: An Institutional Experience

Diagnostic Cytopathology, EarlyView.
ABSTRACT Background There is a decreased cervical cancer screening rate among female to male transgender (FTMTG) patients. Data on the distinct cytologic features present in cervical cytology (CC) of those on testosterone therapy is limited. Methods An 2017–2023 electronic database search identified CC specimens from a cohort of FTMTG patients on ...
Juanita E. Ferreira, Nikki Chiang, Xin Jing, Brian Smola, Richard L. Cantley, Judy C. Pang, Madelyn Lew   +6 more
wiley   +1 more source

Treatment of Men for “Low Testosterone”: A Systematic Review

PLoS ONE, 2016
Testosterone products are recommended by some prescribers in response to a diagnosis or presumption of “low testosterone” (low-T) for cardiovascular health, sexual function, muscle weakness or wasting, mood and behavior, and cognition.
Samantha Huo, A. Scialli, Sean C. McGarvey, E. Hill, Buğra Tügertimur, Alycia Hogenmiller, Alessandra I. Hirsch, A. Fugh-Berman   +7 more
semanticscholar   +1 more source

Detection of a Single Microdose of Testosterone and Recombinant EPO in Healthy Volunteers

Drug Testing and Analysis, EarlyView.
Exogenous T was detected with IRMS regardless of T/E elevation—high serum T indicative for IRMS. rhEPO was detected in urine for 72 h in ITP and CP, and Tasso showed less sensitivity than previous DBS devices tested. ABSTRACT Doping with testosterone (T) and erythropoietin (EPO) in low doses (micro‐doping) is a challenge to detect.
Carmel Heiland, Oscar Hopcraft, Mats Johanson, Anton Pohanka, Mikael Lehtihet, Lena Ekström   +5 more
wiley   +1 more source