Results 101 to 110 of about 169,506 (312)
Mendelian randomization with fine-mapped genetic data: choosing from large numbers of correlated instrumental variables [PDF]
arXiv, 2017 Mendelian randomization uses genetic variants to make causal inferences about the effect of a risk factor on an outcome. With fine-mapped genetic data, there may be hundreds of genetic variants in a single gene region any of which could be used to assess this causal relationship.
arxiv
Sex‐Based Disparities in Sinonasal Outcomes: A Population‐Based Study
International Forum of Allergy &Rhinology, EarlyView.
Victoria S. Lee +5 more
wiley +1 more source
New Pyridobenothiazolone Derivatives Display Nanomolar Pan‐Serotype Anti‐Dengue Virus Activity
ChemMedChem, EarlyView.A ligand‐based strategy is employed, starting from hit compound 2, to develop the C‐2 modified pyridobenzothiazolone 19 as a pan‐serotype nanomolar DENV‐1‐4 inhibitor. Investigations of the mechanism reveal the peculiar ability to abolish the infectivity of virions in a second infection.
Tommaso Felicetti +13 more
wiley +1 more source
MethodsXThe aim of this study was to create a continuous drug delivery system that would yield serum testosterone levels in sexually mature, female pigs consistent with serum testosterone levels of human transgender men.
Nirvana Mahabir, Annie E. Newell-Fugate
doaj
Discordance between testosterone measurement methods in castrated prostate cancer patients
Endocrine Connections, 2019 Failure to suppress testosterone below 0.7 nM in castrated prostate cancer patients is associated with poor clinical outcomes. Testosterone levels in castrated patients are therefore routinely measured.
Mélanie Rouleau +12 more
doaj +1 more source
Steroid Receptors and Vertebrate Evolution [PDF]
arXiv, 2019 Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young, appearing in the fossil record during the Cambrian explosion about 542 to 515 million years ago. Results from sequence analyses of genomes from bacteria, yeast, plants, invertebrates and vertebrates indicate that receptors for adrenal steroids (aldosterone ...
arxiv
Evolution in reproductive tempo and investment across the Peromyscus radiation
Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 339, Issue 1, Page 13-27, January 1, 2023., 2023 In this review, we summarize diversity among Peromyscus species and populations in a number of reproductive traits. including litter size. We examine associations with environmental variation (map, right). We also use a large dataset compiled from lab‐held colonies (violin ploots, right) of Peromyscus to test for species‐ and population‐level ...
Kathryn Wilsterman, Kirksey Cunningham
wiley +1 more source
TESTOSTERONE AND AGGRESSION [PDF]
Journal of Offender Rehabilitation, 1994 The evolutionary context of a possible link between testosterone and human aggressiveness is outlined. Age and sex differences in the two variables parallel one another, but are confounded by other influences. Studies comparing aggressive and non-aggressive groups (e.g., violent prisoners) show higher testosterone levels in the former.
openaire +2 more sources
, 2023 IJU Case Reports, Volume 6, Issue 1, Page 53-54, January 2023.
Shinichiro Fukuhara, Norio Nonomura
wiley +1 more source
iScience, 2022 Summary: Testosterone is essential to human growth and development as well as immune regulation. Zika virus (ZIKV), an emerging arbovirus associated with neurological complications including neuroinflammation, can also cause testicular damage and ...
Bohan Zheng +8 more
doaj