Results 61 to 70 of about 183,045 (246)

Testosterone and Cholesterol Vasodilation of Rat Aorta Involves L-Type Calcium Channel Inhibition

Advances in Pharmacological Sciences, 2010
Testosterone has rapid nongenomic vasodilator effects which could be involved in protective cardiovascular actions. Several authors suggested specific mechanisms to explain this effect, but this matter was not clarified yet.
E. Álvarez, E. Cairrão, M. Morgado, C. Morais, I. Verde   +4 more
doaj   +1 more source

Testosterone and androstanediol glucuronide among men in NHANES III

BMC Public Health, 2018
Background Most of the androgen replacement therapies were based on serum testosterone and without measurements of total androgen activities. Whether those with low testosterone also have low levels of androgen activity is largely unknown.
Chuan Wei Duan, Lin Xu
doaj   +1 more source

Dietary Berberine Reduced Oxido‐Inflammatory Stress in Rats' Livers and Kidneys, Supplemented from Prepuberty to Adulthood

ChemFoodChem, EarlyView.
Berberine (BER) demonstrates significant protective effects on the hepatorenal system in rats, mediated through various cellular and molecular mechanisms spanning from the prepubertal stage through adulthood. These mechanisms encompass antioxidant, anti‐inflammatory, and anti‐apoptotic activities, in addition to modulation of essential signalling ...
Solomon Owumi, Bayode Oluwawibe, Harieme Agbarogi, Moses T. Otunla, Uche Arunsi, Jesutosin O. Babalola, Chioma Irozuru, Chima Amadi, Ahmad Altayyar   +8 more
wiley   +1 more source

Pharmacokinetics, Tolerability, and Biomarker Profile of the Neurokinin 3 Receptor Antagonist Fezolinetant in Healthy Japanese Individuals: A 2‐Part, Randomized, Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This 2‐part, randomized, placebo‐controlled, double‐blind, Phase 1 study analyzed the pharmacokinetics, safety, and biomarker profile of fezolinetant in healthy Japanese individuals. Part 1: male participants received single doses of placebo or fezolinetant 15 or 60 mg.
Akira Koibuchi, Megumi Iwai, Kanji Komatsu, Kentaro Kuroishi, Mai Shibata, Masako Saito, Jace Nielsen, Jiayin Huang, Shunji Matsuki   +8 more
wiley   +1 more source

Pleural Metastasis From Male Breast Cancer: A Case Report

Diagnostic Cytopathology, EarlyView.
ABSTRACT Male breast cancer (MBC) is a rare disease accounting for less than 1% of breast cancers and for 0.11% of all male malignancies. Despite the fact that the epidemiologic, clinical, and therapeutic literature regarding female breast cancer is well documented, little is known about the features of male breast cancer.
Patrizia Straccia, Esther Diana Rossi
wiley   +1 more source

Mouse testicular macrophages can independently produce testosterone and are regulated by Cebpb

Biological Research
Background Testicular macrophages (TM) have long been recognized for their role in immune response within the testicular environment. However, their involvement in steroid hormone synthesis, particularly testosterone, has not been fully elucidated.
Nengliang Duan, Yuanshuai Ran, Huapei Wang, Ya Luo, Zhixiang Gao, Xingyu Lu, Fengmei Cui, Qiu Chen, Boxin Xue, Xiaolong Liu   +9 more
doaj   +1 more source

Biosynthesis and Identification of Clenbuterol Metabolites in Urine and In Vitro Microsome Incubation Samples Using UHPLC‐Q‐Exactive Orbitrap Mass Spectrometry: A Comparison Between Human and Bovine Metabolism

Drug Testing and Analysis, EarlyView.
Clenbuterol metabolism was studied in bovine and human urine using LC‐Q‐Exactive‐Orbitrap MS; eight metabolites were identified in human and bovine samples as well as a novel N‐methylated form. Four urinary metabolites specific to cattle were detected and identified.
Anuar Gómez‐Tagle, Claudia Bressan, Rosa Ventura, Alan Álvarez‐Sanchez, Enrique Cardenas‐Yong, Benjamín Velasco‐Bejarano   +5 more
wiley   +1 more source

Detection of Anabolic Androgenic Steroids and Steroid Esters—Comparing Dried Blood Spots Collection Devices and Urine Samples

Drug Testing and Analysis, EarlyView.
DBS (Capitainer‐B50 and Tasso‐M20) enabled detection of testosterone esters in all participants, whereas urine testing (T/E) missed cases including potential UGT2B17 del/del carriers and individuals with testosterone prescription. More AAS and steroid‐esters could be detected in Capitainer‐B50 versus Tasso‐M20.
Tina Suominen, Jeanette von Walden, Laura Harju, Anton Pohanka, Jenny Schulze, Mikael Lehtihet, Lena Ekström   +6 more
wiley   +1 more source

NÍVEIS PERIFÉRICOS DE TESTOSTERONA TOTAL EM TOUROS GUZERÁ

Ciência Animal Brasileira, 2014
Twenty-four Guzerat bulls were evaluated from 24 to 34 months of age, aiming to determinate the bulls serum testosterone concentration profile and their variation according to age, body weight and andrologic traits.
Juliano Cesar Dias, Venício José de Andrade, Lucas Luz Emerick, Jorge André Matias Martins, Vicente Ribeiro do Vale Filho   +4 more
doaj   +1 more source

Prevalence of AAS‐Positive Samples at Drug Abuse Laboratory Sweden Between 2014 and 2023 and Sub‐Study of Dual Use of AAS and Narcotics

Drug Testing and Analysis, EarlyView.
Throughout 2014–2023, over 20,000 AAS analyses have been conducted at the drug of abuse laboratory, Karolinska University Hospital. Approximately 20% and 2% of the samples have been positive for AAS, with no trends of increase or decrease. Around 50% of the AAS‐positive samples were also positive for narcotics (year 2022–2023), with gender differences;
Kim Petterson Bohlin, Tomas Villén, Oscar Hopcraft, Anton Pohanka, Lena Ekström   +4 more
wiley   +1 more source