Results 71 to 80 of about 312,372 (339)
Advanced Science, EarlyView.This study investigates a highly multivalent mAb platform fusing Laminin‐511 heterotrimerization domains with Fabs and IgG1‐Fc as a non‐hormonal contraceptive. The most potent molecule ‘LamH10’, possessing 10 Fabs, rapidly achieved >99% reduction in progressively motile sperm at just 33µg per dose in sheep, making the laminin‐IgG hybrid platform the ...
Alison Schaefer +8 more
wiley +1 more source
Sex Hormone Binding Globulin Modifies Testosterone Action and Metabolism in Prostate Cancer Cells
International Journal of Endocrinology, 2016 Sex Hormone Binding Globulin (SHBG) is the major serum carrier of sex hormones. However, growing evidence suggests that SHBG is internalised and plays a role in regulating intracellular hormone action.
Huika Li +8 more
doaj +1 more source
Frontiers in Ecology and Evolution, 2016 Testosterone is an important sex hormone and mediates reproduction in male vertebrates. There is ample evidence that testosterone coordinates the expression of physiological, morphological and behavioural traits during reproduction and many of these ...
Beate Apfelbeck +3 more
doaj +1 more source
Advanced Science, EarlyView.Schematic overview showing that forkhead box O6, opposite strand (Foxo6os) acts as a “scaffold”, directly binding myosin‐binding protein‐C (MYBPC3) and recruiting protein kinase C (PKC‐α) to mediate site‐specific phosphorylation of MYBPC3. This post‐translational modification supports cardiac contraction by regulating L‐type Ca2+ channels, especially ...
Jie Sheng +9 more
wiley +1 more source
Kidney International Reports, 2017 Infectious diseases are the second highest cause of death in patients on dialysis. In addition, testosterone deficiency or hypogonadism is prevalent in dialysis patients.
Akio Nakashima +5 more
doaj +1 more source
CO2‐DBU‐Triggered Photoredox‐Catalyzed Direct α‐C‐H Alkylation of Alcohols
Advanced Science, EarlyView.An efficient photoinduced and metal‐free method is developed for direct α‐C–H monoalkylation of alcohols utilizing the CO2‐DBU system as the hydrogen bond acceptor (HBA) in the presence of H2O, allowing for selective functionalization of alcohols with a broad substrate scope.
Zeyu Zhang +5 more
wiley +1 more source
PLoS ONE, 2017 Context Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality. Objectives Examine the direction and causality of the relationship between body mass index (BMI) and serum ...
J. Eriksson +16 more
semanticscholar +1 more source
Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives
Aggregate, EarlyView.Triterpenoids serve as both exceptional molecular motifs for supramolecular assembly and versatile therapeutic agents, offering broad biological functions to improve health outcomes and enhance treatment efficacy. This review comprehensively summarizes recent advances in triterpenoid‐based supramolecular systems, including their roles as functional ...
Jie Zhong +3 more
wiley +1 more source
Sex-Specific Associations of Testosterone With Metabolic Traits
Frontiers in Endocrinology, 2019 Background: Testosterone levels are differentially linked with diabetes risk in men and women: lower testosterone levels in men and higher testosterone levels in women are associated with type 2 diabetes, though, the mechanisms are not fully clear.
Stefan Z. Lutz +31 more
doaj +1 more source
An association between adropin hormone and total testosterone in obese men: a case-control study
BMC Endocrine Disorders, 2022 Background Obesity is associated with low testosterone levels that could be caused by many mechanisms. Adropin, a peptide hormone, its levels are decreased in obesity and its receptors are expressed in the hypothalamus, the pituitary gland, and the ...
Asmaa A. Muhammed +3 more
doaj +1 more source