Results 71 to 80 of about 4,135 (231)

Fecal corticosterone metabolite levels in two closely related rodent species in a sub‐Mediterranean environment

Wildlife Biology, EarlyView.
Glucocorticoids regulate many physiological functions and play an important role in coping with challenging stimuli. The non‐invasive assessment of glucocorticoids is increasingly used as a tool to evaluate individual and population health status in wild animals.
Carlo Cinque, Cristina Bencini, Paola Bartolommei, Andrea Bonacchi, Stefania Gasperini, Emiliano Manzo, Roberto Cozzolino   +6 more
wiley   +1 more source

Hormone Replacement Therapy Uptake and Discontinuation Trends From 1996‐2023: An Observational Study of the Welsh Population

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To analyse prescribing trends for oral and transdermal hormone replacement therapy (HRT) in Wales from 1996 to 2023, including predictors of discontinuation within one year of initiation. Design Observational study using the Secure Anonymised Information Linkage (SAIL) databank.
Robin Andrews, Arron Lacey, Kate Bache, Emma J. Kidd   +3 more
wiley   +1 more source

Short‐Term Severe Energy Restriction Promotes Molecular Health and Reverses Aging Signatures in Adults With Prediabetes in the PREVIEW Study

Aging Cell, EarlyView.
Severe short‐term energy restriction in adults with prediabetes led to a significant reduction in circulating proteins linked to inflammation, senescence, and protein turnover. These changes, partly mediated by extracellular vesicles, suggest systemic dietary‐induced benefits beyond glycemic control, including improved aging biomarkers.
Maria Lastra Cagigas, Andrius Masedunskas, Yao Lin, Samantha J. Emery‐Corbin, Jumana M. Yousef, Laura F. Dagley, Sam Olechnowicz, Rory Bowden, Rachael Hayward, Gary Low, Roslyn Muirhead, Jennie Brand‐Miller, Mikael Fogeltholm, Anne Raben, Marco Demaria, Stephen J. Fuller, Luigi Fontana   +16 more
wiley   +1 more source

Dietary Selenium Deficiency Accelerates the Onset of Aging‐Related Gut Microbial Changes in Aged Telomere‐Humanized Mice, With Akkermansia muciniphila Being the Most Prominent and Alleviating Selenium Deficiency‐Induced Type 2 Diabetes

Aging Cell, EarlyView.
Gut Akkermansia muciniphila is enriched by dietary selenium deficiency in aged telomere‐humanized mice and counteracts dietary selenium deficiency‐induced type 2 diabetes. ABSTRACT Previous studies have shown that dietary selenium (Se) deficiency in mice reshapes gut microbiota, exacerbates healthspan deterioration (e.g., type 2 diabetes), and ...
Ying‐Chen Huang, Hsin‐Yi Lu, Li Zhang, Alicia Olivier, Tung‐Lung Wu, Chuan‐Yu Hsu, Caleb LeGrand, Huawei Zeng, Samantha Curran, Qingzhou Wang, Ramakrishna Nannapaneni, Xue Zhang, Max Ticó, Marco Mariotti, Ryan T. Y. Wu, Gerald F. Combs Jr, Wen‐Hsing Cheng   +16 more
wiley   +1 more source

The Role of Transdermal Testosterone Patch Over Pregnancy Rates in Poor Ovarian Responders Undergoing ICSI Cycles [PDF]

, 2019
Hassan FI, Mahmoud Salah Shehata, Waleed Abd Al-Galel EL-Sheikh, Mostafa M.M. Younis   +3 more
openalex   +1 more source

Single‐Cell Sequencing Reveals That CD4+ T Cells Eliminate Senescent Prostate Epithelium to Delay Progression of Benign Prostatic Hyperplasia

Aging Cell, EarlyView.
Senescent BPH epithelial cells secrete CXCL13 to recruit CD4+ T cells via CXCR5. Cytotoxic CD4+ T cells eliminate senescent cells through MHC‐II–dependent recognition. Tregs suppress, while B cells show minimal effect. This immune axis modulates senescent cell clearance and may influence BPH progression.
Zheng Li, Xiaofei Wang, Zhifu Liu, Senmao Li, Zhenan Zhang, Chenchen Huang, Yixiao Liu, Xingxing Tang, Jiaen Zhang, Peimin Zhou, Ying Gan, Yu Fan, Yisen Meng, Kaiwei Yang, Shuai Hu, Qian Zhang, Wei Yu   +16 more
wiley   +1 more source

Associations of plasma sex‐related hormone and protein levels and alcohol dependence

Addiction, EarlyView.
Abstract Background and Aims Sex‐related hormones and proteins may underlie sex differences in alcohol use disorder characteristics and consequences. Previous reports suggest steroid sex hormones may influence alcohol consumption behaviors while proteins that regulate their circulation levels are rarely investigated.
Ada Man‐Choi Ho, Jennifer R. Geske, Vanessa K. Pazdernik, T. Cameron Waller, Anthony Batzler, Stacey J. Winham, Victor M. Karpyak   +6 more
wiley   +1 more source

Testicular histopathology and its association with germ cell numbers, serum concentrations of reproductive hormones, and semen quality

Andrology, EarlyView.
Abstract Background It is well‐established that spermatogenesis, semen quality, and reproductive hormones are interlinked. It is, however, less well‐described how various specific testicular histopathologies are linked to reproductive hormones and semen quality.
Gülizar Saritas, Nina Mørup, Trine H. Johannsen, Anders Juul, Lise Aksglaede, Sofia B. Winge, Kristian Almstrup   +6 more
wiley   +1 more source

Testosterone transdermal patch (TTP) significantly improved sexual function in naturally menopausal women in a large Phase III study [PDF]

, 2004
Robin Kroll, Susan R. Davis, Michèle Moreau, Arthur Waldbaum, Jan L. Shifren, Kathryn Wekselman   +5 more
openalex   +1 more source

Evaluation of dimethandrolone undecanoate in non‐human primates as a candidate for long‐acting injectable male contraceptive

Andrology, EarlyView.
Abstract Background Dimethandrolone undecanoate (DMAU) is under development as a single agent hormonal male contraceptive. DMAU is a prodrug hydrolyzed by esterase(s) to the active metabolite dimethandrolone (DMA) which has dual androgenic and progestogenic actions.
Deborah I. Bunin, Kyuri Kim, Toufan Parman, Janet Gahagen, Mary B. Zelinski, Tiffany Adevai, Christina Wang, Liang Tang, Lalitha Iyer, Aaron Endsley, Diana L. Blithe, Min S. Lee   +11 more
wiley   +1 more source