Results 71 to 80 of about 563,660 (283)

Glucocorticoid Receptor Activation Reprograms NK Cells to Drive AREG‐Mediated Immunosuppression: A Pan‐Cancer Role for AREG

open access: yesAdvanced Science, EarlyView.
Natural killer cells, central to anti‐tumor defense, undergo unexpected reprogramming within the tumor microenvironment. Instead of producing IFN‐γ and TNF‐α, they elevate amphiregulin, a tumor‐promoting factor. This shift is linked to glucocorticoid receptor activity and prostaglandin signaling.
Qin Wei   +8 more
wiley   +1 more source

Masculine Vitality: Pros and Cons of Testosterone in Treating the Andropause [PDF]

open access: yes, 2003
As our population ages, concerns about frailty and disability, as well as the all-too-human desire to remain young for as long as possible have led increasing numbers of women and men to the questionable practice of restoring diminishing hormone levels ...
Judith Estrine, Nora O'Brien
core  

Randomized controlled trials - mechanistic studies of testosterone and the cardiovascular system [PDF]

open access: yes, 2018
Testosterone deficiency is common in men with cardiovascular disease (CVD), and randomized placebo-controlled trials (RCTs) have reported beneficial effects of testosterone therapy on exercise-induced cardiac ischemia in chronic stable angina, functional
Alexander   +104 more
core   +3 more sources

μ‐Opioid Receptor Dynamics in the Parameningeal Tissue During Migraine Attacks

open access: yesAnnals of Neurology, EarlyView.
Objective The possible impact of meningeal μ‐opioid receptor (μOR) binding in migraine remains unknown. This study investigated μOR availability in the cranial parameninges involved in migraine initiation via nociceptor activation. Methods We used positron emission tomography with [11C] carfentanil, and measured μOR availability in meninges and ...
Dajung J. Kim   +6 more
wiley   +1 more source

An Investigation of Hyperostosis Frontalis Interna in a Modern Anatomical Body Donor Population

open access: yesClinical Anatomy, EarlyView.
ABSTRACT This research sought to examine the prevalence and severity of hyperostosis frontalis interna (HFI) in the Chicagoland anatomical body donor population. The study further aimed to elucidate potential demographic risk factors for HFI, including sex, age at death, and structural vulnerability index (SVI), as well as any common comorbidities, as ...
Amy C. Beresheim, Amanda Hall
wiley   +1 more source

Plumage Variation, Plasma Steroids and Social Dominance in Male House Finches [PDF]

open access: yes, 1994
In male House Finches (Carpodacusm exicanus), the extent and color of plumage varies depending on access to carotenoid pigments. Colorful males exhibit extensive red pigmentation, while less colorful (i.e., drab ) males exhibit carotenoid pigmentation
Belthoff, James R.   +2 more
core   +2 more sources

Potent Antisickling Furaldehyde Analogs for Acute Sickle Cell Therapy: Enhanced Efficacy and Intravenous Formulation Potential

open access: yesChemMedChem, EarlyView.
This study reports novel 5‐HMF analogs with potent antisickling activities. Lead compound MMA509 enhances hemoglobin oxygen affinity and prevents erythrocyte sickling. Crystal structure of hemoglobin‐MMA509 complex explains MMA509 mechanism of action. An IV formulation is successfully developed, positioning MMA509 as a promising fast‐acting treatment ...
Abdelsattar M. Omar   +15 more
wiley   +1 more source

Fatigue and cognition - hormonal perspectives [PDF]

open access: yes, 2013
Fatigue is a common complaint and considered a very challenging symptom to cope with in many different medical diseases. The assessment of fatigue is bound up with the problems of both conceptualization and definition.
Möller, Marika
core   +1 more source

Pharmacokinetics, Tolerability, and Biomarker Profile of the Neurokinin 3 Receptor Antagonist Fezolinetant in Healthy Japanese Individuals: A 2‐Part, Randomized, Phase 1 Study

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract This 2‐part, randomized, placebo‐controlled, double‐blind, Phase 1 study analyzed the pharmacokinetics, safety, and biomarker profile of fezolinetant in healthy Japanese individuals. Part 1: male participants received single doses of placebo or fezolinetant 15 or 60 mg.
Akira Koibuchi   +8 more
wiley   +1 more source

Timing feedback-inhibition of the male reproductive hormone axis [PDF]

open access: yes, 2008
Hormonal methods of male contraception have addressed feedback-inhbition of the cascade of hormones that has evolved to regulate sperm production but high concentrations of testosterone (T) in the blood have not worked satisfactorily.
Amit Misra   +4 more
core   +2 more sources

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