Results 151 to 160 of about 305,776 (233)
A Transferable IncC-IncX3 Hybrid Plasmid Cocarrying blaNDM-4, tet(X), and tmexCD3-toprJ3 Confers Resistance to Carbapenem and Tigecycline. [PDF]
mSphere, 2021 Hirabayashi A +9 more
europepmc +1 more source
ChemPhysChem, Volume 27, Issue 5, 13 March 2026.The design of DNA‐PAINT docking strands critically influences spatial resolution and signal stability. By comparing single (1 × R1) and repetitive (5 × R1) docking architectures on PCNA, we reveal how binding kinetics and localization precision determine the accuracy of sub‐10 nm imaging in protein nanostructures. DNA points accumulation for imaging in
Dominic A. Helmerich +5 more
wiley +1 more source
Silent Partners in the Mill: Unveiling the Role of Additives in Mechanochemical Synthesis
Chemistry – A European Journal, Volume 32, Issue 9, 2 March 2026.Mechanochemistry offers a sustainable, solvent‐free alternative to traditional synthesis, often enhanced by additives in a process known as additive‐assisted grinding. This review discusses how various additives, including liquids, ionic solids, and advanced materials like ionic liquids and piezoelectric compounds, improve reaction efficiency ...
Johanna Breinsperger +3 more
wiley +1 more source
Export of miRNAs from activated macrophages is cooperative and HuR‐dependent
FEBS Letters, Volume 600, Issue 5, Page 693-709, March 2026.This study uncovers a new mechanism for miRNA export regulation in mammalian cells, driven by the RNA‐binding protein HuR. In macrophages, HuR cooperatively binds with miRNAs to export both low‐ and high‐affinity substrates, thereby influencing macrophage activation.
Syamantak Ghosh +2 more
wiley +1 more source
Molecular Oncology, Volume 20, Issue 3, Page 804-822, March 2026.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Advanced Science, Volume 13, Issue 18, 27 March 2026.This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang +11 more
wiley +1 more source
Advanced Science, Volume 13, Issue 16, 18 March 2026.We investigate by proteomics studies how strand‐symmetric and ‐asymmetric cytosine 5‐modifications in DNA are selectively recognized by the nuclear proteome. Using promoter probes with defined modification patterns, we identify tissue‐specific reader proteinsincluding MYC, MAX, and RFX5that discriminate 5‐hydroxymethylcytosine symmetry and sequence ...
Lena Engelhard +8 more
wiley +1 more source
Advanced Science, Volume 13, Issue 17, 23 March 2026.Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao +14 more
wiley +1 more source
Activity of Tigecycline or Colistin in Combination with Zidovudine against Escherichia coli Harboring tet(X) and mcr-1. [PDF]
Antimicrob Agents Chemother, 2020 Zhou YF +5 more
europepmc +1 more source