Results 1 to 10 of about 158 (87)

A novel inhibitor of monooxygenase reversed the activity of tetracyclines against tet(X3)/tet(X4)-positive bacteria

EBioMedicine, 2022
Summary: Background: Tigecycline is one of the few last-resort antibiotics for the treatment of carbapenem-resistant Enterobacteriaceae infection, the incidence of which has been rapidly increasing.
Lei Xu, Yonglin Zhou, Sen Niu
exaly   +3 more sources

Occurrence and Molecular Characterization of Abundant tet(X) Variants Among Diverse Bacterial Species of Chicken Origin in Jiangsu, China

Frontiers in Microbiology, 2021
Many novel tigecycline-inactivating enzymes encoded by tet(X) variants from different bacteria were discovered since the plasmid-mediated tet(X3) and tet(X4) genes conferring high-level resistance to tigecycline in Enterobacterales and Acinetobacter were
Kai Peng, Xinran Sun, Ruichao Li
exaly   +3 more sources

Characterization of two multidrug-resistant Klebsiella pneumoniae harboring tigecycline-resistant gene tet(X4) in China

Frontiers in Microbiology, 2023
ObjectivesTigecycline is recognized as one of the last-line antibiotics to treat serious bacterial infection caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). The plasmid-borne gene tet(X4) mediates high resistance to tigecycline. However, the
Yanxian Yang, Yanxian Yang, Yanxian Yang, Ruowen He, Ruowen He, Ruowen He, Ruowen He, Yiping Wu, Yiping Wu, Yiping Wu, Mingyang Qin, Mingyang Qin, Jieyun Chen, Jieyun Chen, Jieyun Chen, Yu Feng, Yu Feng, Yu Feng, Runping Zhao, Lei Xu, Xilong Guo, Xilong Guo, Xilong Guo, Guo-Bao Tian, Guo-Bao Tian, Guo-Bao Tian, Min Dai, Bin Yan, Bin Yan, Bin Yan, Li-Na Qin, Li-Na Qin   +31 more
doaj   +1 more source

Uncovering the diverse hosts of tigecycline resistance gene tet(X4) in anaerobic digestion systems treating swine manure by epicPCR

Water Research X, 2023
The tet(X4) gene is a clinically important tigecycline resistance gene and has shown high persistence in livestock-related environments. However, the bacterial hosts of tet(X4) remain unknown due to the lack of appropriate approaches.
Shiting Dai, Qing He, Ziming Han, Wenli Shen, Ye Deng, Yang Wang, Wei Qiao, Min Yang, Yu Zhang   +8 more
doaj   +1 more source

Prevalence and risk factors of tet(X4)-positive Enterobacteriaceae in human gut microbiota

Journal of Global Antimicrobial Resistance, 2022
: Objectives: This work is aimed to investigate the prevalence of tet(X4) in healthy individuals and patients and assess risk factors associated with tet(X4)-positive populations.
Yu Zeng, Li Deng, Xianyuan Zhou, Chi Zhang, Zhen Hu, Yunsheng Chen, Weidong Zheng   +6 more
doaj   +1 more source

Decoding the enigma: unveiling the molecular transmission of avian-associated tet(X4)-positive E. coli in Sichuan Province, China

Poultry Science, 2023
: Tigecycline is considered one of the “last resort antibiotics” for treating complex infections caused by multidrug-resistant (MDR) bacteria, especially for combating clinical resistant strains that produce carbapenemases.
Shaqiu Zhang, Jinfeng Wen, Yuwei Wang, Zhijun Zhong, Mingshu Wang, Renyong Jia, Shun Chen, Mafeng Liu, Dekang Zhu, Xinxin Zhao, Ying Wu, Qiao Yang, Juan Huang, Xumin Ou, Sai Mao, Qun Gao, Di Sun, Bin Tian, Anchun Cheng   +18 more
doaj   +1 more source

Emerging Opportunity and Destiny of mcr-1- and tet(X4)-Coharboring Plasmids in Escherichia coli

Microbiology Spectrum, 2021
The emergence of the plasmid-mediated colistin resistance gene mcr-1 and the plasmid-mediated tigecycline resistance gene tet(X4) represents a significant threat to public health.
Xiaoyu Lu, Xia Xiao, Yuan Liu, Ruichao Li, Zhiqiang Wang   +4 more
doaj   +1 more source

Persistence of plasmid and tet(X4) in an Escherichia coli isolate coharboring blaNDM-5 and mcr-1 after acquiring an IncFII tet(X4)-positive plasmid

Frontiers in Microbiology, 2022
The prevalence of plasmid-mediated tigecycline resistance gene tet(X4) is presenting an increasing trend. Once tet(X4)-bearing plasmids are captured by multidrug-resistant bacteria, such as blaNDM and mcr-coharboring bacteria, it will promote bacteria to
Xia Xiao, Xia Xiao, Ziyi Liu, Ziyi Liu, Xiaojun Chen, Xiaojun Chen, Kai Peng, Kai Peng, Ruichao Li, Ruichao Li, Ruichao Li, Yuan Liu, Yuan Liu, Yuan Liu, Zhiqiang Wang, Zhiqiang Wang   +15 more
doaj   +1 more source

Tigecycline-resistant Escherichia coli ST761 carrying tet(X4) in a pig farm, China

Frontiers in Microbiology, 2022
This study aimed to investigate the prevalence and characterization of tet(X4) in Escherichia coli isolates from a pig farm in Shanghai, China, and to elucidate tet(X4) dissemination mechanism in this swine farm. Forty-nine (80.33%) E.
Jing Wang, Jing Wang, Meng-Jun Lu, Meng-Jun Lu, Zhen-Yu Wang, Zhen-Yu Wang, Yue Jiang, Yue Jiang, Han Wu, Han Wu, Zhi-Ming Pan, Zhi-Ming Pan, Xinan Jiao, Xinan Jiao   +13 more
doaj   +1 more source

Widespread Dissemination of Plasmid-Mediated Tigecycline Resistance Gene tet(X4) in Enterobacterales of Porcine Origin

Microbiology Spectrum, 2022
The emergence of the plasmid-mediated high levels of the tigecycline resistance gene has drawn worldwide attention and has posed a major threat to public health.
Qin Wang, Changwei Lei, Hansen Cheng, Xue Yang, Zheren Huang, Xuan Chen, Zijing Ju, Haoyu Zhang, Hongning Wang   +8 more
doaj   +1 more source