Results 11 to 20 of about 158 (87)

Comprehensive Genomic Investigation of Tigecycline Resistance Gene tet(X4)-Bearing Strains Expanding among Different Settings

Microbiology Spectrum, 2021
The emergence of plasmid-mediated tigecycline resistance genes has attracted a great deal of attention globally. Currently, no comprehensive in-depth genomic epidemiology study of tet(X4)-bearing pathogens present of pork origin as the One Health ...
Ruichao Li, Yan Li, Kai Peng, Yi Yin, Yuan Liu, Tao He, Li Bai, Zhiqiang Wang   +7 more
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Deciphering the Structural Diversity and Classification of the Mobile Tigecycline Resistance Gene tet(X)-Bearing Plasmidome among Bacteria

mSystems, 2020
The emergence of novel plasmid-mediated resistance genes constitutes a great public concern. Recently, mobile tet(X) variants were reported in diverse pathogens from different sources.
Ruichao Li, Xiaoyu Lu, Kai Peng, Ziyi Liu, Yan Li, Yuan Liu, Xia Xiao, Zhiqiang Wang   +7 more
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Comparison of Fitness Cost, Stability, and Conjugation Frequencies of tet(X4)-Positive Plasmids in Chicken and Pig Escherichia coli

Antibiotics, 2022
The large-scale epidemic of the tet(X4) gene in the livestock and poultry industry is threatening public health; however, there is still a lack of comparative studies on tet(X4)-bearing plasmids in chicken and pig Escherichia coli.
Ziyi Liu, Huiru Zhang, Xia Xiao, Yuan Liu, Ruichao Li, Zhiqiang Wang   +5 more
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Histone-Like Nucleoid Structuring Protein Modulates the Fitness of tet(X4)-Bearing IncX1 Plasmids in Gram-Negative Bacteria

Frontiers in Microbiology, 2021
The emergence of plasmid-mediated tigecycline resistance gene tet(X4) poses a challenging threat to public health. Based on the analysis of tet(X4)-positive plasmids in the NCBI database, we found that the IncX1-type plasmid is one of the most common ...
Wenhui Cai, Feifei Tang, Lijie Jiang, Ruichao Li, Ruichao Li, Ruichao Li, Ruichao Li, Zhiqiang Wang, Zhiqiang Wang, Zhiqiang Wang, Yuan Liu, Yuan Liu, Yuan Liu, Yuan Liu   +13 more
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Presence of Mobile Tigecycline Resistance Gene tet(X4) in Clinical Klebsiella pneumoniae

Microbiology Spectrum, 2022
The recently emerged plasmid-mediated tigecycline resistance gene tet(X4) has mainly been detected in Escherichia coli but never in Klebsiella pneumoniae. Herein, we identified a clinical K.
Weishuai Zhai, Yingxin Tian, Mi Lu, Muchen Zhang, Huangwei Song, Yulin Fu, Tengfei Ma, Chengtao Sun, Li Bai, Yang Wang, Dejun Liu, Ying Zhang   +11 more
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Fecal Carriage of Escherichia coli Harboring the tet(X4)-IncX1 Plasmid from a Tertiary Class-A Hospital in Beijing, China

Antibiotics, 2022
The emergence of the mobile tigecycline-resistance gene, tet(X4), poses a significant threat to public health. To investigate the prevalence and genetic characteristics of the tet(X4)-positive Escherichia coli in humans, 1101 human stool samples were ...
Weishuai Zhai, Yingxin Tian, Dongyan Shao, Muchen Zhang, Jiyun Li, Huangwei Song, Chengtao Sun, Yang Wang, Dejun Liu, Ying Zhang   +9 more
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Prevalence of tet(X4) in Escherichia coli From Duck Farms in Southeast China

Frontiers in Microbiology, 2021
ObjectivesCarbapenems, colistin, and tigecycline are critically important antibiotics in clinics. After the global appearance of blaNDM and mcr mediating the resistance to carbapenems and colistin, respectively, tigecycline becomes the last-resort drug ...
Yang Yu, Yang Yu, Chao-Yue Cui, Xu Kuang, Chong Chen, Min-Ge Wang, Xiao-Ping Liao, Xiao-Ping Liao, Jian Sun, Jian Sun, Ya-Hong Liu, Ya-Hong Liu   +11 more
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Characterization of an Escherichia coli Isolate Coharboring the Virulence Gene astA and Tigecycline Resistance Gene tet(X4) from a Dead Piglet

Pathogens, 2023
tet(X4) is the critical resistance gene for tigecycline degradation that has been continually reported in recent years. In particular, pathogenic bacteria carrying tet(X4) are a severe threat to human health.
Jianmei Wang, Yuting Huang, Chunjiu Guan, Jie Li, Hua Yang, Guoping Zhao, Canying Liu, Jiangang Ma, Biao Tang   +8 more
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Advances in mechanism study on novel tetracycline-inactivating enzymes tet(X) causing emerging tigecycline resistance [PDF]

Zhenduanxue lilun yu shijian, 2023
Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next-generation tetracycline that is the final line of defense against severe infections by carbapenem-resistant Gram-negative bacteria.
SHEN Pinghua, CHEN Huifen
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IncHI1 plasmids are epidemic vectors that mediate transmission of tet(X4) in Escherichia coli isolated from China

Frontiers in Microbiology, 2023
IntroductionThis study aimed to investigate the genetic factors promoting widespread Q6 dissemination of tet(X4) between Escherichia coli and to characterize the genetic contexts of tet(X4).MethodsWe isolated E.
Yan Zhang, Yan Zhang, Jie Zhang, Jie Zhang, Ping Cai, Ping Cai, Yang Lu, Yang Lu, Ruan-Yang Sun, Ruan-Yang Sun, Meng-Tao Cao, Meng-Tao Cao, Xiao-Li Xu, Mark A. Webber, Hong-Xia Jiang, Hong-Xia Jiang   +15 more
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