Results 31 to 40 of about 158 (87)

Large-Scale Analysis of Fitness Cost of tet(X4)-Positive Plasmids in Escherichia coli

Frontiers in Cellular and Infection Microbiology, 2022
Tigecycline is one of important antimicrobial agents for the treatment of infections caused by multidrug-resistant (MDR) Gram-negative bacteria. However, the emergence and prevalence of plasmid-mediated tigecycline resistance gene tet(X4) are threatening
Feifei Tang, Wenhui Cai, Lijie Jiang, Zhiqiang Wang, Zhiqiang Wang, Zhiqiang Wang, Yuan Liu, Yuan Liu, Yuan Liu, Yuan Liu   +9 more
doaj   +1 more source

Genomic characterization revealing the high rate of tet(X4)-positive Escherichia coli in animals associated with successful genetic elements

Frontiers in Microbiology
IntroductionThe rapid spread of plasmid-mediated tet(X4) conferring high tigecycline resistance poses a significant threat to public health. Escherichia coli as the most common pathogen which carries tet(X4) has been widely disseminated in China.
Li Shao, Changbu Wu, Changbu Wu, Changbu Wu, Changbu Wu, Chengjuan Li, Ruowen He, Ruowen He, Ruowen He, Guanping Chen, Guanping Chen, Guanping Chen, Guanping Chen, Guanping Chen, Dandan Sun, Yanxian Yang, Yanxian Yang, Yanxian Yang, Yanxian Yang, Yu Feng, Yu Feng, Yu Feng, Yu Feng, Guili Zhang, Guili Zhang, Guili Zhang, Guili Zhang, Guili Zhang, Bin Yan, Bin Yan, Min Dai, Guo-Bao Tian, Guo-Bao Tian, Guo-Bao Tian, Guo-Bao Tian, Guo-Bao Tian, Lan-Lan Zhong, Lan-Lan Zhong, Lan-Lan Zhong, Lan-Lan Zhong   +39 more
doaj   +1 more source

Duplex Recombinase Polymerase Amplification‐Lateral Flow Assay for Rapid Visual Detection of Critical Antibiotic Resistance Genes in Escherichia coli and Klebsiella pneumoniae From Positive Blood Cultures

Journal of Clinical Laboratory Analysis, EarlyView.
This study developed a pair of duplex RPA‐LFA assays for the simultaneous detection of critical resistance genes, blaCTX‐M/mcr‐1 and blaoxa‐48‐like/blaNDM, from hemoculture samples. Under optimized conditions, duplex RPA was performed at 37°C–38°C for 25 min, followed by LFA for 10–15 min.
Variya Nemidkanam, Pattamaporn Deechart, Nuntaree Chaichanawongsaroj   +2 more
wiley   +1 more source

Genomic epidemiology and lineage‐specific risk stratification of tet(X4)‐mediated tigecycline resistance along the pork production chain: A One Health perspective

iMetaOmics, Volume 3, Issue 2, June 2026.
Genome surveillance across a swine‐associated One Health continuum in China shows that slaughterhouses act as major enrichment nodes for tet(X4)‐mediated tigecycline resistance, driven by putative clonal transmission and stable plasmid backbones. Integrating global datasets enables lineage‐specific risk stratification, highlighting key control points ...
Qin Wang, Qiwu Yuan, Xuan Chen, Yujing Zhong, Ke Wu, Renqiao Wen, Luya Liu, Xiaoqin Wang, Cui Li, Hongning Wang, Changwei Lei   +10 more
wiley   +1 more source

A Genomic Catalog of Migratory Microbiomes from Wild Birds across China's Habitats

Advanced Science, Volume 13, Issue 26, 8 May 2026.
ABSTRACT Migratory birds play an important role in the spread of antimicrobial resistance (AMR); however, gaps in surveillance data from vital regions along migratory flyways across China limit the detection of emergent threats. Here, we assembled 340 metagenomes from 52 bird species covering 11 provincial administrative districts in China, presenting ...
Yanan Wang, Heqi Wu, Mengqi Qu, Chunge Zhang, Ziqian Xu, Yuhang Pei, Chaochao Zhao, Jiangtao Wang, Sufang Ma, Na Lyu, Xuebin Xu, Yuhai Bi, Baoli Zhu, George F. Gao   +13 more
wiley   +1 more source

Reversing Antibiotic Resistance: Strategies From Adjuvants to Innovative Therapeutics

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Molecular reversal strategies against antibiotic resistance act through three mechanisms: inhibiting resistance gene function, blocking horizontal gene transfer, and modulating host defense. Emerging technologies, such as CRISPR‐Cas gene editing, photodynamic therapy, nanotechnology, and ecological competition, further strengthen these approaches ...
Tianjiao Li, Fei Zeng, Jie Zhang, Yuangong Zhang, Wenjuan Yin   +4 more
wiley   +1 more source

The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2023–2024

EFSA Journal, Volume 24, Issue 2, February 2026.
Abstract This report presents the main findings of the 2023–2024 harmonised antimicrobial resistance (AMR) monitoring in Salmonella spp., Campylobacter jejuni and Campylobacter coli from humans, food‐producing animals (broilers, laying hens, fattening turkeys, fattening pigs and bovines under 1 year of age), and derived meat.
European Food Safety Authority (EFSA), European Centre for Disease Prevention and Control (ECDC)   +1 more
wiley   +1 more source

The Effect of Antibiotic and Nonantibiotic Drugs on Plasmid‐Mediated Bacterial Conjugation

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Background The clinical utility of antibiotics has been eroded by the emergence of antibiotic resistance. One major mechanism by which microorganisms develop resistance to antibiotics and nonantibiotics is by horizontal gene transfer (HGT) via plasmid‐mediated conjugation.
Marcus Daitey Larnyoh, Seth Kwabena Amponsah, Abigail Offei, Emmanuel Kwaku Ofori, Ofosua Adi-Dako, Awo Afi Kwapong, Shweta Negi   +6 more
wiley   +1 more source

A novel ABC family protein participates in the regulation of fitness cost caused by tet(X4)-bearing plasmids in Escherichia coli

Fundamental Research
The worldwide prevalence of the plasmid-mediated tigecycline resistance gene tet(X4) in diverse bacterial species challenges the clinical application of tigecycline and poses an increasing threat to global health.
Haijie Zhang, Lijie Jiang, Yurong Zhao, Mengping He, Zhiqiang Wang, Yuan Liu   +5 more
doaj   +1 more source

Bismuth Drugs Reverse Tet(X)-Conferred Tigecycline Resistance in Gram-Negative Bacteria

Microbiology Spectrum, 2022
Antibiotic resistance has caused a serious threat to public health and human safety. Recently, the emergence of novel resistance gene tet(X4) and its variants threatens the clinical utility of tigecycline, one of the last-line antibiotics for multidrug ...
Tian Deng, Yuqian Jia, Ziwen Tong, Jingru Shi, Zhiqiang Wang, Yuan Liu   +5 more
doaj   +1 more source