Results 201 to 210 of about 305,776 (233)

Crystallization of and preliminary X-ray diffraction data for TET-repressor and the TET-repressor-tetracycline complex

Journal of Molecular Biology, 1984
The TET-repressor encoded by the transposon Tn10 has been crystallized along with the repressor-tetracycline complex. Both crystals belong to the space group P43212 (or P41212) with cell dimensions a = b = 74.3(1) A, c = 94.2(2) A and a = b = 73.3(1) A, c = 94.6(2) A for the free and complexed repressor, respectively. There is one molecule of molecular
H E, Parge, M, Schneider, V, Hahn, W, Saenger, L, Altschmied, W, Hillen   +5 more
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The poultry pathogen Riemerella anatipestifer appears as a reservoir for Tet(X) tigecycline resistance

Environmental Microbiology, 2021
Summary The transferability of bacterial resistance to tigecycline, the ‘last‐resort’ antibiotic, is an emerging challenge of global health concern. The plasmid‐borne tet (X) that encodes a flavin‐dependent monooxygenase represents a new mechanism for tigecycline resistance.
Zeeshan Umar, Qiwei Chen, Biao Tang, Yongchang Xu, Jinzi Wang, Huimin Zhang, Kai Ji, Xu Jia, Youjun Feng   +8 more
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Emerging High‐Level Tigecycline Resistance: Novel Tetracycline Destructases Spread via the Mobile Tet(X)

BioEssays, 2020
AbstractAntibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next‐generation tetracycline that is the final line of defense against severe infections by pan‐drug‐resistant bacterial pathogens. Unfortunately, this last‐resort antibiotic has been challenged by the recent emergence of the mobile Tet(X ...
Liang‐Xing Fang, Chong Chen, Chao‐Yue Cui, Xing‐Ping Li, Yan Zhang, Xiao‐Ping Liao, Jian Sun, Ya‐Hong Liu   +7 more
openaire   +2 more sources

Crystallization and preliminary X-ray analysis of the Tet-repressor/operator complex

Acta Crystallographica Section D Biological Crystallography, 1998
Three crystal forms of the repressor protein TetR class D in complex with the palindromic 17 bp operator sequence containing T overhangs on both sides were obtained by hanging-drop vapor-diffusion methods using PEG 4000 and PEG monomethylether 5000 as precipitants. Although the crystallization conditions were very similar, up to three different crystal
P, Orth, C, Alings, D, Schnappinger, W, Saenger, W, Hinrichs   +4 more
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Preparation, characterization and X-ray structure of {[(3,2,3-tet)Ni(μ-CO3)Ni(3,2,3-tet)][(3,2,3-tet)Cu]}(ClO4)4: a heteronuclear trimetallic complex containing hydrogen bonds

Inorganic Chemistry Communications, 2000
Abstract A heteronuclear trimetallic complex {[(3,2,3-tet)Ni(μ-CO3)Ni(3,2,3-tet)][(3,2,3-tet)Cu]}4+ (3,2,3-tet=N,N′-bis(3-aminopropyl)ethylenediamine) has been prepared by the reaction of Ni(II), 3,2,3-tet, Na2CO3 and Cu(3,2,3-tet)(ClO4)2 in situ. The complex is composed of two units, [(3,2,3-tet)Ni(μ-CO3)Ni(3,2,3-tet)]2+ and [Cu(3,2,3-tet)]2+, which
Chee-Hun Kwak, Jinkwon Kim
openaire   +1 more source

Reducing tetracycline antibiotics residues in aqueous environments using Tet(X) degrading enzymes expressed in Pichia pastoris

Science of The Total Environment, 2021
Tetracycline antibiotics (TCs) are massively produced and consumed in various industries resulting in large quantities of residuals in the environment. In this study, to achieve safe and efficient removal of residual TCs, a Pichia pastoris (P. pastoris) was gained to stably express glycosylated TCs degrading enzyme Tet(X) followed codon and expression ...
Qian, He, Chao-Yue, Cui, Xiao-Jing, Zhang, Zhuo-Yu, Lin, Qiu-Lin, Jia, Cang, Li, Hao, Ren, Da-Tong, Cai, Zi-Jian, Zheng, Teng-Fei, Long, Xiao-Ping, Liao, Ya-Hong, Liu, Jian, Sun   +12 more
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Co‐production of Tet(X) and MCR ‐1, two resistance enzymes by a single plasmid

Environmental Microbiology, 2021
Summary Tigecycline and colistin are few of ‘last‐resort’ antibiotic defences used in anti‐infection therapies against carbapenem‐resistant bacterial pathogens. The successive emergence of plasmid‐borne tet (X) tigecycline resistance mechanism and mobile colistin resistance (
Yongchang Xu, Lizhang Liu, Huimin Zhang, Youjun Feng   +3 more
openaire   +2 more sources

Global distribution and genomic characteristics of tet(X)-positive Escherichia coli among humans, animals, and the environment

Science of The Total Environment, 2023
In recent years, the plasmid-mediated transmission of the tigecycline resistance gene tet(X) in Escherichia coli has received considerable attention. However, studies on the global distribution of tet(X)-positive E. coli remain scarce. Herein, we performed a systematic genomic analysis of 864 tet(X)-positive E.
Yan, Li, Xinran, Sun, Xia, Xiao, Zhiqiang, Wang, Ruichao, Li   +4 more
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Dissemination of the tet(X)-Variant Genes from Layer Farms to Manure-Receiving Soil and Corresponding Lettuce

Environmental Science & Technology, 2021
The occurrence of high-level tigecycline resistance tet(X) variant genes represents a new transferable resistance crisis to food safety and human health. Here, we investigated the abundance of tet(X)-variant genes [tet(X), tet(X1) to tet(X6)] in 33 samples collected from layer manures, manured/un-manured soils, and corresponding lettuce from three ...
Tao He, Rui-Cheng Wei, Lili Zhang, Lan Gong, Lei Zhu, Jili Gu, Yu-Lin Fu, Yang Wang, De-Jun Liu, Ran Wang   +9 more
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Spreading Ability of Tet(X) -Harboring Plasmid and Effect of Tetracyclines as a Selective Pressure

Microbial Drug Resistance
Tigecycline is a last-resort antimicrobial in humans. Tetracyclines are the most widely used antimicrobials in livestock. Mobile tigecycline resistance genes [ tet(X) ] are disseminated worldwide, and tetracycline use may have promoted the selection of tet(X)
Akira Fukuda, Yuta Kozaki, Cemil Kürekci, Yasuhiko Suzuki, Chie Nakajima, Masaru Usui   +5 more
openaire   +2 more sources