Results 141 to 150 of about 54,573 (154)

One global disseminated 193 kb high-risk hybrid plasmid harboring tet(X4), mcr or blaNDM threatening public health.

Science of the Total Environment, 2023
In Shanghai, the prevalence of tet(X4) and tet(X4)-carrying plasmid from food-producing -animal Enterobacteriales has not been intensively investigated. Here, five tet(X4)-positive swine-origin E.
Min Li, H. Zhang, Wengang Zhang, Ying Cao, Bingqing Sun, Qin Jiang, Yu Zhang, Haodong Liu, Wen Guo, Cheng Chang, Nan Zhou, Chao Lv, Chaoyi Guo, Xiaokui Guo, Jun Shang, Shixin Huang, Yongzhang Zhu   +16 more
semanticscholar   +1 more source

Extensive spread of tet(X4) in multidrug-resistant Escherichia coli of animal origin in western China

Veterinary Microbiology, 2022
The recent emergence of plasmid-mediated tigecycline resistance gene tet(X) variants represents a threat to public health. tet(X4) is highly endemic in northwestern China. Here, we extended the region to western China to further understand its epidemiology and distribution.
Jie, Feng, Mengru, Su, Kun, Li, Jiangang, Ma, Ruichao, Li, Li, Bai, Xinglong, Wang, Juan, Wang, Zengqi, Yang   +8 more
openaire   +2 more sources

Genome-wide insight into the evolution and global transmission of tigecycline resistant tet(X4)-carrying Klebsiella species across reservoirs.

International Journal of Antimicrobial Agents
The emergence of plasmid mediated tet(X4) gene compromises the clinical utility of tigecycline and underscores growing concerns regarding its environmental reservoirs and potential for interspecies transmission, particularly within Klebsiella species. To
Yuye Wu, Yawen Yu, Xueqian He, Weifang Mao, Qian Tong, Danni Bao, H. Jia, Yingying Kong, Yingying Zhang, Mohamed S. Draz, J. P. R. Furlan, Patrick Butaye, Mohamed Elhadidy, Shurong Dong, Zhen-Hui Cao, Xinyou Xie, Shengjun Wu, Zhi Ruan   +17 more
semanticscholar   +1 more source

Genomic and functional analysis of high-level tigecycline resistant Klebsiella michiganensis co-carrying tet(X4) and tmexCD2-toprJ2 from pork.

Journal of food microbiology, 2023
Tigecycline plays an important role in the clinical treatment of infections caused by multidrug-resistant pathogens. The emergence of plasmid-mediated tigecycline resistance genes tet(X) and tmexCD1-tmexJ1 has been reported in a variety of animal and ...
Y. Li, Lei Xu, Yuhan Li, Mianzhi Wang, Tao He, L. Bai, Ruichao Li, Zhiqiang Wang   +7 more
semanticscholar   +1 more source

Recent discoveries of propyl gallate restore the antibacterial effect of tigecycline against tet(X4)-positive Escherichia coli.

Biochemical Pharmacology
Propyl gallate (PG), an approved food additive, can be added to different foods and drugs to provide health benefits with minimal danger. However, no clinical application of PG as an antibacterial agent for the treatment of antimicrobial resistance (AMR)
Zhiying Liu, Qianyu Zhou, Jinjing Xue, Minhe Cui, Lei Xu, Tianqi Fang, Zhongmei Wen, Dan Li, Jianfeng Wang, Xuming Deng, Yonglin Zhou   +10 more
semanticscholar   +1 more source

Mobile tigecycline resistance gene tet(X4) persists with different animal manure composting treatments and fertilizer receiving soils

Chemosphere, 2022
The emergence of plasmid-mediated tigecycline-resistant genes [tet(X3)to tet(X6)] in animals and humans has raised serious concerns over their possible cross-environmental dissemination. However, behavior of these emerging mobile tet(X)-variant genes in manure treatment processes, particularly for different composting treatments, has not yet been ...
Shiting Dai, Dejun Liu, Ziming Han, Yang Wang, Xiaofei Lu, Min Yang, Yu Zhang   +6 more
openaire   +2 more sources

Emergence of a conjugative hybrid plasmid co-harboring mcr-1.1, mcr-3.39, and tet(X4) in Escherichia coli from wastewater in Seoul: A potential threat to last-line antibiotics.

Science of the Total Environment
The emergence of plasmid-mediated antimicrobial resistance to last-line antibiotics such as colistin and tigecycline poses an escalating public health threat.
Jin Seok Kim, Young Hee Jin, Jinwoo Kim, Chang-Kyu Kim, Sook Hyun Park, Ahryung Oh, YoungAh Yoo, Jae In Lee, Jihun Jung   +8 more
semanticscholar   +1 more source

Emergence and Characterization of the High-Level Tigecycline Resistance Gene tet(X4) in Salmonella enterica Serovar Rissen from Food in China

Foodborne pathogens and disease
The plasmid-mediated tet(X4) gene has exhibited a high-level resistance to tigecycline (TGC), which has raised concerns globally regarding antibiotic resistance.
Hongzhi Zhang, Wenjie Chen, Xiaoyu Lu, Yingying Liang, Xiao Quan, Xin Liu, Tianqi Shi, Ying Yu, Ruichao Li, Huanyu Wu   +9 more
semanticscholar   +1 more source

The effect of triclosan on intergeneric horizontal transmission of plasmid-mediated tigecycline resistance gene tet(X4) from Citrobacter freundii isolated from grass carp gut.

Environmental Pollution
The transmission of antibiotic resistance genes (ARGs) in pathogenic bacteria affects culture animal health, endangers food safety, and thus gravely threatens public health. However, information about the effect of disinfectants - triclosan (TCS) on ARGs
Xinxin Jiang, Jingfei Long, Yanzhen Song, Xiaoyu Qi, Ping Li, Kuiquan Pan, Chenyang Yan, Hongzhou Xu, Haixia Liu   +8 more
semanticscholar   +1 more source

[Synergistic effect of β-thujaplicin and tigecycline against tet(X4)-positive Escherichia coli in vitro].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2023
The widespread of tigecycline resistance gene tet(X4) has a serious impact on the clinical efficacy of tigecycline. The development of effective antibiotic adjuvants to combat the looming tigecycline resistance is needed. The synergistic activity between the natural compound β-thujaplicin and tigecycline in vitro was determined by the checkerboard ...
Muchen, Zhang, Huangwei, Song, Zhiyu, Zou, Siyuan, Yang, Hui, Li, Chongshan, Dai, Dejun, Liu, Bing, Shao, Congming, Wu, Jianzhong, Shen, Yang, Wang   +10 more
openaire   +1 more source