Results 71 to 80 of about 18,141 (217)

Transient Facial Nerve Paralysis (Bell's Palsy) following Intranasal Delivery of a Genetically Detoxified Mutant of Escherichia coli Heat Labile Toxin.

, 2009
BACKGROUND: An association was previously established between facial nerve paralysis (Bell's palsy) and intranasal administration of an inactivated influenza virosome vaccine containing an enzymatically active Escherichia coli Heat Labile Toxin (LT ...
Kromann Ingrid, Woodrow, M, Novicki Deborah, Huo, Z, Del Giudice Giuseppe, Novicki, D, Rappuoli Rino, Thierry-Carstensen, B, Susan Barnett, Galiza, E, David J M Lewis, Rafaela Giemza, Andersen, P, Peter Andersen, Lewis David J. M., Barnett Susan, Maria Woodrow, Kromann, I, Giuseppe Del Giudice, Thierry-Carstensen Birgit, Giemza Rafaela, Ingrid Kromann, Andersen Peter, Lewis, DJ, Galiza Eva, Giemza, R, Huo Zhiming, Woodrow Maria, Deborah Novicki, Eva Galiza, Birgit Thierry-Carstensen, Rino Rappuoli, Del Giudice, G, Rappuoli, R, Barnett, S, Zhiming Huo   +35 more
core   +1 more source

Neutralization of Lethal Potency of Tetanus Toxin using Phage Display Produced scFv Antibody

, 2021
Background and Aim: Phage display technology provides a new approach for making human antibody fragments that could be applicable in passive immune therapy.
Abbasi, Ebrahim, Aminian, Mahdi, Khalili, Ehsan   +2 more
core   +1 more source

Studies on Tetanus Toxin and Toxid. II. Isolation and Characterization of the Tetanus Toxin and Toxoid [PDF]

Australian Journal of Biological Sciences, 1968
Crude tetanus toxin and toxoid were prepared by methanol precipitation. The toxin was purified by a combination of TEAE·cellulose and Sephadex G·200 chromatography at pH values less than 6· o. The toxoid was purified by DEAE· cellulose at approximately neutral pH values.
D J, Dawson, C M, Mauritzen
openaire   +2 more sources

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

More than a Toxin: Protein Inventory of Clostridium tetani Toxoid Vaccines

Proteomes, 2019
Clostridium tetani is the etiological agent of tetanus, a life-threatening bacterial infection. The most efficient protection strategy against tetanus is a vaccination with the C.
Jens Möller, Max Edmund Kraner, Andreas Burkovski   +2 more
doaj   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, Volume 13, Issue 34, 19 June 2026.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

Theranostic Advancements in Brain Cancer: Promising Approaches for Emerging Therapy

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Strategies for improving intra‐arterial administration (A) and photodynamic therapy in brain cancer (B). Improving intra‐arterial (IA) administration and photodynamic therapy (PDT) for brain cancer involves enhancing tumor targeting and breaching the blood–brain barrier (BBB). Key strategies include super selective catheterization, using osmotic agents
Bipraban Khanra, Manoj Kumar Sarangi
wiley   +1 more source

Tetanus Toxin-enhanced GABA Immunoreactivity in Living Neurons

, 1998
Analysis of the connectivity between different neuronal cell types is dependent on an appreciation of their dendritic and axonal arborizations. A detailed study of the dendrites and axons of GABAergic neurons has been thwarted by the lack of a suitable ...
John Mitchell
core   +1 more source

KNDy kisspeptin is required for metabolic homeostasis in female mice in an ovarian hormone‐independent manner

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Disorders of gonadotropin pulsatility contribute to reproductive dysfunction in humans and are often associated with metabolic dysfunction. Hypogonadotropic hypogonadism is characterized by chronically insufficient gonadotropin hormone production, leading to reproductive and metabolic impairments, such as infertility and obesity.
Nimisha Nandankar, Ariel L. Negrón, Harshini Ganesh, Natalia Youssef, Saad Farooq, Sarmed Al‐Samerria, Jon E. Levine, Sally Radovick   +7 more
wiley   +1 more source

Sustained Effector Functions and Memory Accumulation of αβ T Cells in Children With Congenital Heart Disease

European Journal of Immunology, Volume 56, Issue 5, May 2026.
This study showed dysregulated αβ T cell homeostasis with ongoing T cell activation and low‐grade inflammation in 5‐12‐year‐old CHD children who underwent early‐life cardiac surgery with thymectomy, characterized by reduced naïve T cells and increased memory/effector and senescent‐like T cells.
Yusuf Eshimutu Abu, Christoph Kammeyer, Tao Yang, Rodrigo Gutierrez Jauregui, Alexa Cramer, Claudia Junge, Svea Kleiner, Anika Janssen, Adan Chari Jirmo, Alexander Horke, Reinhold Förster, Philipp Beerbaum, Martin Boehne, Sarina Ravens   +13 more
wiley   +1 more source