Results 51 to 60 of about 19,875 (210)
Clinical and Translational Science, Volume 18, Issue 12, December 2025.ABSTRACT Janus kinase inhibitors (JAKIs) are immunomodulatory drugs used for autoimmune and inflammatory conditions. Their potential impact on pregnancy and fetal development remains a concern due to placental transfer and potential disruption of cytokine and growth factor signaling, with limited human data.
Nazanin Abolhassani +7 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 118, Issue 5, Page 1132-1142, November 2025.Novel compounds targeting the adaptive immune system are commonly initially investigated in healthy volunteers (HV). HV frequently lack constitutively expressed drug‐target engagement biomarkers, complicating the evaluation of pharmacological activity. The keyhole limpet hemocyanin (KLH) neo‐antigen challenge elicits a controlled immune response in HV ...
Micha N. Ronner +10 more
wiley +1 more source
International Journal of Cancer, Volume 157, Issue 9, Page 1912-1923, 1 November 2025.What's new? While melanoma vaccines have shown therapeutic promise, predicting their clinical benefits is challenged by factors such as delayed response to immunotherapy and scarcity of biomarkers. Here, the authors examined the long‐term efficacy of vaccination with either 4 or 12 class I MHC‐restricted peptides in high‐risk melanoma.
Emily K. Ninmer +3 more
wiley +1 more source
Trends in neonatal and post-neonatal tetanus admissions at a Nigerian teaching hospital
Journal of Infection in Developing Countries, 2012 Introduction: Tetanus accounts for high morbidity and case fatality rates in developing countries. This study therefore aimed to identify reasons for the persistence of this disease.
Olusola Adetunji Oyedeji +4 more
doaj +1 more source
Systemic treatment of immune checkpoint inhibitor‐induced psoriasis: Inference‐based guidance
Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 11, Page 1881-1894, November 2025.When managing psoriasis, induced or exacerbated by ICI therapy for cancer, there are concerns regarding immunosuppression from systemic agents for the treatment of psoriasis and the potential impact on ICI efficacy. No direct, high‐level evidence exists to address these concerns.
Kim A. Papp +14 more
wiley +1 more source
Western Pacific Surveillance and Response, 2013 Maternal or neonatal tetanus causes deaths primarily in Asia and Africa and is usually the result of poor hygiene during delivery. In 2011, three neonatal tetanus cases were investigated in Papua New Guinea, and all three cases were delivered at home by ...
Grace Kariwiga +6 more
doaj +1 more source
Pediatric Allergy and Immunology, Volume 36, Issue 11, November 2025.Abstract Background Primary Atopic Disorders (PAD) represent a recently recognized subset of inborn errors of immunity (IEI), characterized by severe atopy driven by genetic mutations leading to dysregulated type 2 immune responses, excessive mast cell activation, and hyper production of IgE.
Fabio Cardinale +46 more
wiley +1 more source
Bodily distress syndrome after receiving vaccines: A case report
Journal of General and Family Medicine, 2019 A 48‐year‐old woman presented with various symptoms, including widespread body pains, insomnia, palpitations, and shortness of breath, after receiving tetanus toxoid.
Kentaro Iwata, Yoshiaki Katsuda
doaj +1 more source
Clinical Case Reports, Volume 13, Issue 10, October 2025.ABSTRACT Tetanus is a life‐threatening disease preventable by immunization through vaccines. In resource‐limited settings, its association with other acute infections should be managed cautiously. A 4‐year‐old unvaccinated male was referred from a nearby hospital for better management of severe malaria and probable enteric fever, after presenting there
Christian Damien Tchuisseu Ngapjang +8 more
wiley +1 more source