Results 131 to 140 of about 37,055 (264)

Dynamic Regulation of Endogenous Transcription Factor Hubs at Single‐Molecule Resolution

Advanced Science, EarlyView.
This study combines single‐molecule microscopy and genome editing to characterize the dynamic behaviors of endogenous oncofusion transcription factor EWS::FLI1 in Ewing sarcoma cells. EWS::FLI1 forms neomorphic hubs that dynamically assemble and dissolve. The hubs are regulated during mitosis, by RNA, and by specific chemicals.
Shawn Yoshida, Yanghao Zhong, Akiko Kumagai, William G. Dunphy, Shasha Chong   +4 more
wiley   +1 more source

Peroxisome calcium uptake is dependent on ER-peroxisome membrane contact. [PDF]

Cell Mol Life Sci
Kalinowski J, Hartmann Y, Lütkemeyer A, Thoms S.   +3 more
europepmc   +1 more source

Tethered [PDF]

The Permanente Journal, 2009
openaire   +1 more source

Mechanozyme: An Artificial Enzyme With a Mechanophore Framework

Advanced Science, EarlyView.
Mechanical destabilization of a G‐quadruplex mechanophore in a DNAzyme markedly boosts its catalytic activity, demonstrating “mechanozymes” as artificial enzymes whose functions are modulated by mechanical stress exerted by ultrasonication. This mechanozyme principle is broadly applicable to control biomolecular activities.
Jiahao Ji, Pravin Pokhrel, Sajan Shakya, Bishal Pokhrel, Grinsun Sharma, Pratiksha Chaudhary, Hao Shen, Hanbin Mao   +7 more
wiley   +1 more source

A bis-macrocylic peptide ligand mimicking the β-sandwich active site of multicopper oxidases. [PDF]

Dalton Trans
Dang VT, Drena A, Telser J, Wofford L, Nguyen AI.   +4 more
europepmc   +1 more source

Mechanically Triggered DNA Nanovehicles for Targeted Dual‐Drug Cancer Therapy

Advanced Science, EarlyView.
A mechanically triggered DNA nanovehicle is introduced that co‐releases two anticancer drugs in response to integrin‐mediated cellular forces. Cholesterol‐anchored DNA assemblies undergo force‐induced unfolding at cell–cell junctions, enabling selective, localized dual‐drug activation in cancer cells while minimizing off‐target toxicity in low‐tension ...
Murali Mohana Rao Singuru, Priyanka Bhattacharyya, Mingxu You   +2 more
wiley   +1 more source

Using optical tweezers to characterise physical tethers at membrane contact sites: grab it, pull it, set it free?

Frontiers in Cell and Developmental Biology, 2016
Imogen eSparkes
doaj   +1 more source

Tethered UAV Autonomous Knotting on Environmental Structures for Transport. [PDF]

Cyborg Bionic Syst
Jin R, Xu X, Yang Y, Li J, Cao M, Xie L.
europepmc   +1 more source

Dynamic Self‐Clickable Decellularized Matrix Hydrogels for Regulating Vascularity and Enhancing Muscle Regeneration

Advanced Science, EarlyView.
Dynamic decellularized hydrogels are prepared using bovine decellularized small intestine submucosa (SIS) norbornene (dSIS‐NB). Bovine dSIS contained significant amounts of disulfide‐rich fibrillin‐I, enabling ‘self‐clickable’ thiol‐norbornene gelation and spatiotemporal tuning of hydrogel physicochemical properties.
Van Thuy Duong, Tuba Marjan, Ngoc Ha Luong, Taimoor H. Qazi, Chien‐Chi Lin   +4 more
wiley   +1 more source

Bifunctional Catalysis of a Crossed Aldol Condensation by Diamines: Impact of Tether Composition and Length. [PDF]

J Org Chem
Lampkin PP, Roberts RC, Czeslawski B, Gellman SH.   +3 more
europepmc   +1 more source